Gestational trophoblastic disease in women aged 50 or more

Tsuji, Naoki; Iwasaka, Tsuyoshi; Kashimura, Y; Uchino, H; Kashimura, Masamichi; Matsuyama, Tomohiro

doi:10.1016/0090-8258(85)90124-6

Cited by 70 publications

(39 citation statements)

References 5 publications

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“…Although choriocarcinoma 6 years after menopause and 29 years after the last pregnancy was recently reported [21], GTD in postmenopausal women is extremely rare. Tsukamoto et al [22] reported on 50 cases of GTD at age 50 or older.…”

Section: Discussionmentioning

confidence: 99%

Gonadotropin-Releasing Hormone-Induced Elevation of Serum hCG in Choriocarcinoma: A Case Report.

et al. 1998

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Abstract. We evaluated the effect of GnRH on the serum hCG level in gestational trophoblastic disease (GTD). Five patients with GTD were studied. Three patients had hydatidiform mole (two complete and one partial mole) and two had choriocarcinoma. Blood samples were collected immediately before and 30, 60 min after the 100 µg GnRH iv injection, followed by hCG assay. Only one case of choriocarcinoma demonstrated an hCG increase after intravenous administration of GnRH (positive GnRH test). In that case, the hCG level dropped to the normal range after eight cycles of chemotherapy but the GnRH test was still positive, suggesting the existence of viable cancer cells. Since the GnRH test became negative, no increase in hCG has been observed, indicating that the patient achieved complete remission. Although a positive GnRH test is not common in GTD, GnRH test before treatment might be useful to find a positive case where the test can be repeated to determine complete remission and the time when the chemotherapy may be discontinued.

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Section: Discussionmentioning

confidence: 99%

Gonadotropin-Releasing Hormone-Induced Elevation of Serum hCG in Choriocarcinoma: A Case Report.

et al. 1998

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“…Gestational choriocarcinoma is a rare complication of pregnancy and usually arises from a prior molar pregnancy or rarely a nonmolar gestation, within one year of the antecedent pregnancy (O'Neill et al, 2008). However, Tsukamoto et al reported three postmenopausal patients with choriocarcinoma, with the periods between the last pregnancy and development of tumor being 11, 15 and 18 years (Tsukamoto et al, 1985). Our patient who still had menstruation had her last pregnancy with artificial abortion 10 years ago.…”

Section: Discussionmentioning

confidence: 85%

Subcutaneous mass as the primary manifestation of gestational choriocarcinoma: A case report

Cheng

Chen

Kuo

et al. 2012

Gynecologic Oncology Case Reports

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“…L'âge paraît jouer un rôle dans le développement des MTP avec un taux de 37 % chez les patientes âgées de plus de 40 ans et de 56 % chez celles âgées de plus de 50 ans [7]. Le bas niveau socioéco-nomique paraît un facteur de risque très important, puisqu'on note les taux d'incidence les plus élevés dans les pays sous-développés où s'y associent fréquemment une malnutrition et une insuffisance en graisses animales et en vitamines [8,9].…”

Section: Discussionunclassified