Maladies trophoblastiques gestationnelles persistantes: une étude de 26 cas

Khanfir, Afef; Masmoudi, Aïda; Toumi, Nozha; Kallel, Lamia; Guermazi, M.; Boudawara, T.; Frikha, M.

doi:10.1007/s12558-010-0058-4

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2014

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“…The toxic death rate of 28% with EPA protocol is unacceptable in the context of a curable disease in more than 80% of cases. The AE protocol, less toxic, was still responsible for a frequent gastrointestinal toxicity (87%) and dermatological side effects in 25% of cases in a retrospective study of Tunisia [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

The uterine choriocarcinoma in postmenopausal women: specificities of diagnosis and treatment

Kaabia¹,

Meddeb²,

Rhim³

et al. 2014

Pan Afr Med J

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Choriocarcinoma is a gestational trophoblastic tumor that mainly affects women of childbearing age. Cases of choriocarcinoma in postmenopausal women are exceptional. Through an observation and literature review, we propose to study the specific diagnosis and treatment features of this tumor in menopausal women. We report the observation of a pure uterine choriocarcinoma, which occurred in post-menopause. The diagnosis was made on the analysis of surgical specimens confirmed by measurement of hCG. Chemotherapy was started after a total hysterectomy and bilateral salpingo-oophorectomy first. The improvement was dramatic after 3 courses of chemotherapy and the patient is in complete remission after five years of monitoring. The primitive forms of pure choriocarcinoma in postmenopausal women are exceptional. Their etiology is poorly understood and their treatment based on chemotherapy.

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Section: Discussionmentioning

confidence: 99%