The uterine choriocarcinoma in postmenopausal women: specificities of diagnosis and treatment

Kaabia, Ons; Meddeb, S.; Rhim, Mohamed Salah; Bibi, M.; Khaïri, H.

doi:10.11604/pamj.2014.19.176.5403

Cited by 6 publications

(8 citation statements)

References 12 publications

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“…Concerning the frequency of appearance, the choriocarcinoma is in the majority of cases gestational, primarily intrauterine located, in cases of extrauterine gestational arising at position of ectopic pregnancy and in cases of non gestational possibly derived from pluripotent germ cells mostly in the ovaries high malignant variant. Primary non gestational choriocarcinoma derives from ovary germ cell tumors, residual germ cells or dedifferentiation of endometroid adenocarcinoma and referred mainly to anatomical locations in ovaries and rarely in uterus in postmenopausal period [25][26][27][28].…”

Section: Discussionmentioning

confidence: 99%

“…The Choriocarcinomas, which are highly vascular neoplasms have as main clinical presentation abnormal uterine bleeding and matestasize readily in approximately 30% of cases at the time of the final diagnosis and most commonly in lung 60-75%, vagina 40-50%, brain 15-20%, liver 15-20%, spleen 10%, intestines 10% (5% bowel metastasis), and central nervous system involvement in 10% of cases, very rare manifestation, 4% in cardiac intracavity mass, cardiac metastasis. Approximately 0.76-4% of choriocarcinomas referred to occur in ectopic anatomic locations and they are associated with more aggressive character with distant metastasis [25][26][27][28][29][30][31].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, to these references there were following complications and metastasis locations, specifically: Hcg influence in the thyreotropic action to thyreotoxis based on similar molecular structure Hcg and TSH thyroid stimulating hormone. Hypercoagulability (increasing the activation of platelets, factor XII, X, cytokines TNFa, IL-1,IL-6) [25][26][27][28][29][30][31].…”

Section: Discussionmentioning

confidence: 99%

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Gestational choriocarcinoma in a postmenopausal woman. A case report and literature review

Tsikouras¹,

Chatzipantelis²,

Bothou³

et al. 2020

Cancer Rep Rev

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Choriocarcinoma is the most common tumor of the gestational trophoblastic disease occuring usually in reproductive age related to antedecent gestational event (molar, physiological, ectopic pregnancy, elective or spontaneous abortion) either after one year or after many decades and rarely after the menopause. The main presenting clinical symptom is postmenopausal vaginal bleeding. It is an aggressive tumor with high potential rate to metastasize in various distant organs and is associated with considerable variation in prevalence wordwide.We describe a 51-year-old postmenopausal woman, who presented with heavy vaginal bleeding 27 years after her last pregnancy, 30 years after her last abortion and 3 years after her last menstrual period. Clinical examination,vaginal ultrasound scan, and computer tomography revealed an enlarged uterus at 16 weeks pregnant Gestational choriocarcinoma's diagnosis depended on histological (preoperative endometrial curettage and postoperative uterus examination), immunochemistry findings and hCG elevated levels in serum. The intra and postoperative management was performed according to FIGO guidelines for gestational trophoblastic neoplasia.Early diagnosis and treatment have improved the survival rate. Currently due to the rarity of the tumor in postmenopause period, the difficult differential diagnosis of non gestational choriocarcinoma is of great importance. The presentation of one more case of gestational choriocarcinoma aims to enchance the scientific experience and improve the management.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Gestational choriocarcinoma in a postmenopausal woman. A case report and literature review

Tsikouras¹,

Chatzipantelis²,

Bothou³

et al. 2020

Cancer Rep Rev

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“…We performed a retrospective analysis on a total of 19 cases that were identified as uterine choriocarcinoma in postmenopausal women and reported from 1970 to 2018 2,[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] (Table 1) by reviewing the English-language literature. The resultant 19 patients ranged in age from 50 to 73 y (mean, 58.4 y; median, 58 y).…”

Section: Discussionmentioning

confidence: 99%

Pure nongestational uterine choriocarcinoma in postmenopausal women: a case report with literature review

Wang

Wan

Sun

et al. 2019

Cancer Biology & Therapy

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Nongestational choriocarcinoma is rare, especially in postmenopausal women. It may be derived from the transformation of germ cells or dedifferentiation of other tumor tissue cells. It is usually found in the ovaries but rarely in the uterus. Pure nongestational uterine choriocarcinoma in postmenopausal women is exceptional. Thirty-four cases of choriocarcinoma have been found during the past 25 y at the Tianjin Medical University General Hospital. We retrospectively reviewed the medical records of these 34 cases and found only two cases of nongestational uterine choriocarcinoma, both of which were postmenopausal women. We also reviewed 19 other cases previously reported during the past 50 y (from 1970 to 2018) that were identified as uterine choriocarcinoma in postmenopausal women. Analysis of these combined data indicates that nongestational choriocarcinoma is a rare neoplasm in postmenopausal patients. It genetically originates entirely in the patient, and short tandem repeat (STR) analyses are usually required to differentiate gestational and nongestational choriocarcinoma. Although nongestational choriocarcinoma shows some response to chemotherapy, sensitivity is much poorer than that in gestational choriocarcinoma. The prognosis for nongestational choriocarcinoma is poor and the long-term survival rate is low.

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“…75 to 95% of choriocarcinoma cases can be cured despite distant metastasis; therefore, acurate diagnosis is very important. Also, these patients should be managed by multidisiplinary and experienced team (9).…”

Section: Introductionmentioning

confidence: 99%

Postmenopausal Choriocarcinoma: Case Report and Literature Review

et al. 2017

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Introduction: Choriocarcinoma is a gestational trophoblastic tumor that mainly affects women of childbearing age and rarely occurs in postmenopausal women especially following a long latent period from previous pregnancies. In this case report, we introduce three cases of postmenopausal choriocarcinoma with different clinical signs and symptoms. Case Report: The first patient was admitted with vaginal wall metastasis, and the second and third cases with postmenopausal vaginal bleeding. They were referred to the department of gynecology-oncology at Ghaem hospital in 2015. One case had stage I and two patients stage III of the disease. Treatment was initiated with EMA-CO regimen according to the histopathology of choriocarcinoma in these patients. Complete remission was achieved with chemotherapy for all three cases. Concusions: The possibility of choriocarcinoma should be considered as a differential diagnosis in postmenopausal vaginal bleeding and in postmenopausal women with metestatic lesions.

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The uterine choriocarcinoma in postmenopausal women: specificities of diagnosis and treatment

Cited by 6 publications

References 12 publications

Gestational choriocarcinoma in a postmenopausal woman. A case report and literature review

Gestational choriocarcinoma in a postmenopausal woman. A case report and literature review

Pure nongestational uterine choriocarcinoma in postmenopausal women: a case report with literature review

Postmenopausal Choriocarcinoma: Case Report and Literature Review

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