Gonadotropin-Releasing Hormone-Induced Elevation of Serum hCG in Choriocarcinoma: A Case Report.

Abstract

Abstract. We evaluated the effect of GnRH on the serum hCG level in gestational trophoblastic disease (GTD). Five patients with GTD were studied. Three patients had hydatidiform mole (two complete and one partial mole) and two had choriocarcinoma. Blood samples were collected immediately before and 30, 60 min after the 100 µg GnRH iv injection, followed by hCG assay. Only one case of choriocarcinoma demonstrated an hCG increase after intravenous administration of GnRH (positive GnRH test). In that case, the hCG level dropped to the normal range after eight cycles of chemotherapy but the GnRH test was still positive, suggesting the existence of viable cancer cells. Since the GnRH test became negative, no increase in hCG has been observed, indicating that the patient achieved complete remission. Although a positive GnRH test is not common in GTD, GnRH test before treatment might be useful to find a positive case where the test can be repeated to determine complete remission and the time when the chemotherapy may be discontinued.

Serum human chorionic gonadotropin levels and thyroid hormone levels in gestational transient thyrotoxicosis: Is the serum hCG level useful for differentiating between active Graves’ disease and GTT?

“…and twin pregnancies are also known to cause GTT [6,7].The hCG levels in the GTT group in this study ranged from 20,000 to 220,000 mIU/mL, and there were no correlations between the serum hCG levels and thyroid hormone levels. In addition, there were no significant differences between the thyroid hormone levels or hCG levels of the GTT group without thyroid disease, GTT group with chronic thyroiditis, GTT group with non-functioning thyroid nodules, and GTT group with GD in remission.…”

Mediastinale Metastase eines tubaren Chorionkarzinoms nach ektoper Schwangerschaft als seltene Ursache thorakaler Schmerzen

“…Dabei erfolgt die Metastasierung hämatogen vorwiegend in Lunge, Vagina, Becken, Leber und Gehirn [14,28]. Laborchemisch sind hohe Serum-hCG-Werte charakteristisch für alle Tumormanifestationen [10,28].…”

“…Mediastinal lokalisierte Chorionkarzinome können sowohl sekundär-metastatischen Absiedlungen extrathorakaler Tumoren als auch primär mediastinalen Manifestationen entsprechen. Letztere sind sehr selten und treten fast ausschließlich bei männlichen Patienten auf [5, 8, 20 -22, 27]; laborchemisch ist auch bei betroffenen Männern die Serum-hCG-Konzentration deutlich erhöht [10,23,27]. Ist ein Chorionkarzinom mediastinal lokalisiert, wird es in der Regel im vorderen Mediastinum gefunden.…”