Gestational Trophoblastic Disease and Related Lesions

Mazur, Michael T.; Kurman, Robert J.

doi:10.1007/978-1-4757-3889-6_24

Cited by 47 publications

(45 citation statements)

References 193 publications

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“…Thus, we might need to seek a different biological function for the Bcl-2 expression seen in syncytiotrophoblast. The syncytiotrophoblast is a peculiar multinuclear cell that is believed to be formed following the fusion of cytotrophoblast cells (Mazur and Kurman, 1994;Benirschke and Kaufman, 1995). One of the most significant morphological characteristics of syncytiotrophoblast is that it possesses multiple nuclei sharing the same cytoplasm.…”

Section: Discussionmentioning

confidence: 99%

“…The trophoblast of early gestation is considered to consist of syncytiotrophoblast, cytotrophoblast, and intermediate trophoblast on the basis of their location and morphology (Mazur and Kurman, 1994;Benirschke and Kaufman, 1995). In addition, trophoblast that comprises the basal feet of the anchoring villi represents the most proliferative zone of the extravillous trophoblast and is specifically designated as the 'trophoblast of the cell columns' (Benirschke and Kaufman, 1995).…”

Section: Introductionmentioning

confidence: 99%

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Inverse relationship between apoptosis and Bcl-2 expression in syncytiotrophoblast and fibrin-type fibrinoid in early gestation

Toki¹

1999

Molecular Human Reproduction

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The purpose of this study was to assess the role of apoptosis and cell cycle arrest in the trophoblast during early gestation by determining the location of apoptotic cells and examining the expression of Bcl-2 and p21. Using the terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labelling (TUNEL) method on human chorionic villi, a cluster of apoptotic nuclei was demonstrated in perivillous fibrin-type fibrinoid, but no apoptotic changes were identified in the syncytiotrophoblast or in other subtypes of the trophoblast. The syncytiotrophoblast was diffusely positive for Bcl-2, but fibrin-type fibrinoid was negative for Bcl-2. Hence, there was an inverse relationship between apoptosis and Bcl-2 expression in both fibrin-type fibrinoid and syncytiotrophoblast. Expression of p21 was present to some extent in the syncytiotrophoblast, but not in fibrin-type fibrinoid. These results suggest that Bcl-2 may play an important role in preventing apoptosis in the syncytiotrophoblast; this may be necessary to prevent any DNA degradation from being spread to other nuclei in a multinuclear cell like the syncytiotrophoblast.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Inverse relationship between apoptosis and Bcl-2 expression in syncytiotrophoblast and fibrin-type fibrinoid in early gestation

Toki¹

1999

Molecular Human Reproduction

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“…The first report, a series of 14 cases by Shih and Kurman in 1998, described this unique type of tumor comprised of chorionic type intermediate trophoblastic cells distinct from placental site trophoblastic tumor (PSTT) and choriocarcinoma with features that more closely resembled carcinoma [2,3]. Clinically, these tumors have been shown to present predominantly in reproductive age women with 67% of antecedent gestations being a full term pregnancy [2,4,5].…”

Section: Introductionmentioning

confidence: 97%

Epithelioid trophoblastic tumor: A single institution case series at the New England Trophoblastic Disease Center

Davis

Howitt

Quade

et al. 2015

Gynecologic Oncology

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“…All are characterized by abnormal trophoblast proliferation (17). Partial and complete moles arise from abnormal fertilization resulting in excess paternal genomic material, and have the potential for persistent GTD including metastasis (18).…”

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confidence: 99%

“…Partial and complete moles arise from abnormal fertilization resulting in excess paternal genomic material, and have the potential for persistent GTD including metastasis (18). Despite morphologic differences, it may at times be difficult to distinguish partial from complete moles (17,19). Choriocarcinoma is a highly malignant epithelial tumor that may arise from the trophoblast of any type of gestational event, most commonly in a complete mole.…”

mentioning

confidence: 99%

Immunohistochemical Expression of Cell Cycle Proteins E2F-1, Cdk-2, Cyclin E, p27kip1, and Ki-67 in Normal Placenta and Gestational Trophoblastic Disease

et al. 2001

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The role of cell cycle protein expression in gestational trophoblastic disease is poorly understood. In this study we investigated the immunostaining patterns of G 1 restriction point and G 1 -S regulatory proteins E2F-1, Cdk2, cyclin E, p27 kip1 , and the proliferation marker Ki-67 on routinely processed sections of 29 hydatidiform moles (10 partial moles and 19 complete moles, including 9 persistent moles), 7 choriocarcinomas, and 7 normal placentas. Ki-67 trophoblast staining decreased with increasing gestational age of the placenta, and showed maximal expression in gestational trophoblastic disease. Cyclin-dependent kinase activity, as reflected by Cdk2 expression patterns, also decreased with placental maturation. E2F-1 was uniquely expressed by trophoblasts of moles and choriocarcinoma. Cyclin E was maximally expressed by complete moles and choriocarcinomas, and showed an inverse relationship with the cyclin-dependent kinase inhibitor p27 kip1 . Abnormal trophoblastic proliferations may be mediated through interactions of Cdk-2, E2F-1, cyclin E, and p27 kip1 . Overexpression of cyclin E was associated with more aggressive forms of gestational trophoblastic disease. However, we did not find distinguishing features between complete moles that spontaneously resolved after evacuation and persistent moles that required chemotherapy. The different expression patterns of cyclin E and E2F-1 in partial and complete moles may be useful in distinguishing these two entities. Furthermore, loss of p27 kip1 in malignant trophoblast may represent a necessary step in the development of choriocarcinoma.KEY WORDS: Cdk2, Choriocarcinoma, Cyclin E, E2F-1, Ki-67, p27 kip1 , Trophoblast.Mod Pathol 2001;14(10)

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Gestational Trophoblastic Disease and Related Lesions

Cited by 47 publications

References 193 publications

Inverse relationship between apoptosis and Bcl-2 expression in syncytiotrophoblast and fibrin-type fibrinoid in early gestation

Inverse relationship between apoptosis and Bcl-2 expression in syncytiotrophoblast and fibrin-type fibrinoid in early gestation

Epithelioid trophoblastic tumor: A single institution case series at the New England Trophoblastic Disease Center

Immunohistochemical Expression of Cell Cycle Proteins E2F-1, Cdk-2, Cyclin E, p27kip1, and Ki-67 in Normal Placenta and Gestational Trophoblastic Disease

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