Epithelioid trophoblastic tumor: A single institution case series at the New England Trophoblastic Disease Center

Davis, Michelle; Howitt, Brooke E.; Quade, Bradley J.; Crum, Christopher; Horowitz, Neil S.; Goldstein, Donald P.; Berkowitz, Ross S.

doi:10.1016/j.ygyno.2015.03.006

Cited by 69 publications

(79 citation statements)

References 20 publications

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“…1 Because the biologic behavior and metastatic potential of ETT have been reported to be similar to PSTT, treatment recommendations have generally paralleled those for PSTT, that is, surgical excision and systemic chemotherapy with EMA/EP for metastatic or recurrent disease. 11,12 Based on information provided in 2 of the case series noted previously, 7,8 the response to the EMA/EP regimen in patients with ETT seems poor. In our series, the one patient who received the EMA/EP regimen with normalization of hCG levels and resolution of pulmonary and lymph node disease also had the highest hCG level of 41,000 mIU/mL and had failed prior EMA/CO chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Surgery and Platinum/Etoposide-Based Chemotherapy for the Treatment of Epithelioid Trophoblastic Tumor

Sobecki-Rausch¹,

Winder²,

Maniar³

et al. 2018

International Journal of Gynecological Cancer

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Section: Discussionmentioning

confidence: 99%

Surgery and Platinum/Etoposide-Based Chemotherapy for the Treatment of Epithelioid Trophoblastic Tumor

Sobecki-Rausch¹,

Winder²,

Maniar³

et al. 2018

International Journal of Gynecological Cancer

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“…They are present in women with full term gestation with one to 18 years interval after pregnancy 30 .…”

Section: Epithelioid Trophoblastic Tumor (Ett)mentioning

confidence: 99%

“…Metastatic neoplasm associated with an interval greater than four years from the previous gestation is considered a worse prognostic factor 28,30 . Surgical resection is the pillar of the treatment.…”

Section: Epithelioid Trophoblastic Tumor (Ett)mentioning

confidence: 99%

“…Hysterectomy should be indicated in patients with disease confined to the uterus to maximize the cure opportunity. Davis et al 30 reported that several surgical procedures are frequently required in patients with ETT, particularly in those with extrauterine disease. Higher cure rates are expected when patients are treated at referral centers.…”

Section: Epithelioid Trophoblastic Tumor (Ett)mentioning

confidence: 99%

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The role of surgery in the management of women with gestational trophoblastic disease

Lima

Padrón

Câmara

et al. 2017

Rev. Col. Bras. Cir.

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The Gestational Trophoblastic Disease includes an interrelated group of diseases originating from placental tissue, with distinct behaviors concerning local invasion and metastasis. The high sensitivity of the serial dosages of human chorionic gonadotrophin, combined with advances in chemotherapy treatment, have made gestational trophoblastic neoplasia curable, most often through chemotherapy. However, surgery remains of major importance in the management of patients with gestational trophoblastic disease, improving their prognosis. Surgery is necessary in the control of the disease's complications, such as hemorrhage, and in cases of resistant/relapsed neoplasia. This review discusses the indications and the role of surgical interventions in the management of women with molar pregnancy and gestational trophoblastic neoplasia.

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“…Epithelioid trophoblastic tumor (ETT) is a rare type of gestational trophoblastic neoplasm (GTN) that accounts for less than 2% of all cases of gestational trophoblastic disease. This tumor arises from chorionic‐type intermediate trophoblast cells.…”

Section: Introductionmentioning

confidence: 99%

Laparoscopic diagnosis and treatment of an isolated epithelioid trophoblastic tumor in recto‐uterine pouch

Jiang

Xiang

Guo

2018

J of Obstet and Gynaecol

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A 30-year-old Chinese woman with irregular vaginal bleeding was admitted to our department. Serum β-human chorionic gonadotropin (β-hCG) was moderately elevated, and ultrasound and magnetic resonance imaging revealed an irregular, retro-uterine lesion without intrauterine pregnancy. Ectopic pregnancy was the primary consideration, with trophoblastic tumor being another possibility. Laparoscopy revealed a 2 × 3 × 3 cm irregular, infiltrating, yellow-white lesion in the left recto-uterine pouch, which was completely resected without rectal damage. Final pathological/immunohistochemical analyses revealed an epithelial trophoblastic tumor (ETT) (Ki-67 reactive index~45%). Postoperative recovery was smooth, and the patient received three chemotherapy courses (etoposide, methotrexate and actinomycin, alternating weekly with cyclophosphamide and vincristine) beginning 6 days postsurgery (β-hCG = 46.4 mIU/mL). β-hCG returned to an undetectable level after one chemotherapy course. Herein, we describe a rare case of isolated ETT that was difficult to differentiate from other pregnancy-related diseases. Laparoscopy could be an effective, safe diagnostic method in select patients.

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Epithelioid trophoblastic tumor: A single institution case series at the New England Trophoblastic Disease Center

Cited by 69 publications

References 20 publications

Surgery and Platinum/Etoposide-Based Chemotherapy for the Treatment of Epithelioid Trophoblastic Tumor

Surgery and Platinum/Etoposide-Based Chemotherapy for the Treatment of Epithelioid Trophoblastic Tumor

The role of surgery in the management of women with gestational trophoblastic disease

Laparoscopic diagnosis and treatment of an isolated epithelioid trophoblastic tumor in recto‐uterine pouch

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