Gestational pemphigoid

Abstract

Gestational pemphigoid (pemphigoid gestationis, PG) is a rare autoimmune skin disorder occurring characteristically during pregnancy. Autoantibodies against placental BP180 (also known as BPAG2 or collagen XVII) cause damage to the skin basement membrane, resulting in severe itching and blistering rash over the body and the extremities. The diagnosis of PG is confirmed by immunofluorescence analysis of a skin biopsy, while serum levels of pemphigoid antigen BP180 antibody can be used to assess disease activity. PG with mild symptoms can be treated with topical corticosteroids, while oral corticosteroids are the mainstay in treatment of severe PG. PG usually flares up at the time of delivery, and resolves spontaneously shortly after. However, relapses in subsequent pregnancies are common. As PG has been linked to the risk of prematurity and fetal growth restriction, prenatal monitoring jointly by a dermatologist and an obstetrician is recommended. Mothers should also be informed of the potential risk of re-activation of the disease in subsequent pregnancies and during hormonal contraception.

Pemphigoïde de la grossesse et syndrome de Turner ; une association inhabituelle

“…La survenue d'une éruption bulleuse chez le nouveau-né est rare (moins de 3 % des cas) et transitoire. Elle est liée, au passage transplacentaire des anticorps (de type IgG) maternels [6,10,11]. Le traitement repose sur les dermocorticoïdes, et sur la corticothérapie générale dans les formes profuses.…”

Pemphigoid gestationis: A Moroccan study

“…Linear IgG positivity is also detected in about 25-50% of the samples, but it is not a criterion for the diagnosis [18][19][20].…”

Urticarial Syndromes

“…It is characterized by a severe itchy and bullous eruption due to damage in the basement membrane of the skin by autoantibodies developing against placental BP180 (BPAG2/ collagen XVII) [30]. However, urticarial and eczematous lesions may be seen before and/or during bulla development in some cases.…”