Gestational diabetes mellitus and COVID-19: results from the COVID-19–Related Obstetric and Neonatal Outcome Study (CRONOS)

Kleinwechter, Helmut; Weber, Katharina; Mingers, Nina; Ramsauer, B.; Schaefer-Graf, Ute M.; Groten, T; Kuschel, Bettina; Backes, Clara; Banz‐Jansen, Constanze; Berghaeuser, Martin A; Brotsack, Irene A; Dressler-Steinbach, I; Engelbrecht, Charlotte; Engler-Hauschild, Sarah; Gruber, Teresa-Mira; Hepp, Vanessa; Hollatz-Galuschki, Elsa; Iannaccone, Antonella; Jebens, Anja; Kaisenberg, Constantin S. von; Kaup, Lisa; Keil, C; Kladt, Carolin; Kolben, Thomas; Kraft, K; Kunze, Mirjam; Lastinger, Julia; Luedemann, Katharina; Manz, Jula; Morfeld, C; Parchmann, Olaf; Pfaff, Lena; Reinhardt, Kristin; Runkel, Anne M.; Schmidt, M; Sourouni, Marina; Stelbrink, Johanna; Stubert, Johannes; Stumpfe, Florian M.; Treptow, Anna; Rüdiger, Mario; Pecks, Ulrich

doi:10.1016/j.ajog.2022.05.027

Cited by 45 publications

(44 citation statements)

References 33 publications

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“…In addition, it is currently not known to which extent disturbances in glucose metabolism are reversible over time. It should also be mentioned that worse maternal outcomes for SARS-CoV-2 infection (at the same time or shortly after GDM diagnosis) were reported in one of the previous studies (Kleinwechter et al, 2022).…”

Section: Discussionmentioning

confidence: 83%

“…However, this study has some substantial methodological differences compared with ours. Especially, women who gave birth before the beginning of the pandemic were included in the controlgroup, and it is known that a global increased incidence of GDM has been observed during the pandemic, possibly due to lifestyle changes (Cauldwell et al, 2021;Sun et al, 2021;Kleinwechter et al, 2022;Zanardo et al, 2022). This may explain the diverging findings.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of glucose levels in pregnant women with history of COVID-19 in a case-control study

Monod

Kotzaeridi²,

Eppel³

et al. 2022

Front. Physiol.

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Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection may negatively affect glucose metabolism. This study aims to assess glucose levels, prevalence of gestational diabetes mellitus (GDM) and perinatal outcome in women with history of COVID-19. To this purpose, a group of 65 patients with history of COVID-19 and 94 control patients were retrospectively recruited among pregnant women who attended the pregnancy outpatient department between 01/2020 and 02/2022. Glucose data from an oral glucose tolerance test (OGTT), GDM status and obstetric complications were assessed. We observed no differences in average (p = 0.37), fasting (p = 0.62) or post-load glucose concentrations (60 min: p = 0.19; 120 min: p = 0.95) during OGTT. A total of 15 (23.1%) women in the COVID-19 group and 18 (19.1%) women in the control group developed GDM (p = 0.55). Moreover, caesarean section rate, weight percentiles and pregnancy outcomes were comparable between the groups (p = 0.49). In conclusion, in this study we did not identify a possible impact of COVID-19 on glucose metabolism in pregnancy, especially with regard to glucose concentrations during the OGTT and prevalence of GDM.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Assessment of glucose levels in pregnant women with history of COVID-19 in a case-control study

Monod

Kotzaeridi²,

Eppel³

et al. 2022

Front. Physiol.

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“…In our study, 8% of the women had a moderate disease while 19% of women had severe disease. In various studies, risk factors for severe disease and death in pregnancy include older age (especially ≥35 years), obesity, preexisting medical comorbidities (particularly hypertension, diabetes, or more than one comorbidity), and being unvaccinated (13)(14)(15). No woman in our study was vaccinated, as recommendations for COVID-19 vaccination in pregnancy were not implemented in our country during the study period.…”

Section: Data From the Centers For Disease Control And Prevention (Cd...mentioning

confidence: 93%

Effect of COVID-19 during pregnancy: Studying the maternal and neonatal outcomes and assessing the placental changes related to SARS-CoV-2

Madan

Ramar

Patel

et al. 2022

Preprint

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Background: Pregnant females affected with COVID-19 are reported to have poorer disease outcomes as compared to non-pregnant females of a similar age group. COVID-19 may lead to adverse changes in the placenta, which needs to be studied. Methods: This is a case series of 63 pregnant women hospitalized with COVID-19 from May 2020 to February 2021.The primary outcomes were maternal death or complications. Results: 63 women were studied. 83.3% of women were in the age group of 26 to 35 years. 33% women had associated comorbidities. 68.3% of women tested positive in their third trimester, 15.9% and 11% tested positive in their second and first trimesters respectively. 73% women had mild disease and 27% women required oxygen support. 3/63 women died. One woman in the second and two women in the third trimester died respectively. Histopathological examination in 13 placentae (of 19 placentae examined) were suggestive of maternal and fetal malperfusion. Conclusion: Pregnant COVID-19 women may develop disease-related as well as obstetric complications.

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“…Die Daten wurden über Vergleichs- und Suchalgorithmen auf Plausibilität der Einträge überprüft. Nach Exklusion von Doppelteinträgen, Patientinnen mit fehlender Angabe zum Gestationsalter bei Infektion und nichtverifizierten Testergebnissen konnten 2650 Datensätze für eine weitere Auswertung verwendet werden [ 5 , 12 , 14 ].…”

Section: Methodik Des Cronos-registersunclassified

“…So hat sich ein intensiv arbeitendes Netzwerk in Deutschland etabliert, das die Evidenz zum Umgang mit der Erkrankung in Schwangerschaft, Geburt und Wochenbett für die Betreuung unserer Patientinnen aufbereitet. Zahlreiche wissenschaftliche Arbeiten und nicht zuletzt die AWMF-Leitlinie 015/092 sind hieraus entstanden [ 1 , 5 , 7 , 9 , 12 , 14 ].…”

Section: Kommentarunclassified

COVID-19 in Schwangerschaft, Geburt und Wochenbett

Pecks

Agel²,

Doubek

et al. 2022

Gynäkologie

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COVID(„coronavirus disease“)-19 ist eine Infektionserkrankung, die zu schweren respiratorischen Symptomen führen kann. Schwangere haben ein erhöhtes Risiko für einen schweren Verlauf. Für eine gute Betreuung in der COVID-19-Pandemie wurde daher die AWMF(Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften)-Leitlinie 015/092 „SARS-CoV‑2 in Schwangerschaft, Geburt und Wochenbett“ erstellt. Die Leitliniengruppe nutzte zur Erstellung von evidenzbasierten Handlungsempfehlungen die Daten der „Covid-19 Related Obstetrics and Neonatal Outcome Study“ (CRONOS). CRONOS sammelt deutschlandweit Daten aus mehr als 130 angeschlossenen Geburtenkliniken. SARS-CoV-2(„severe acute respiratory syndrome coronavirus 2“)-positive Schwangere sind demnach häufig asymptomatisch. Bei 1 von 25 erkannten Infektionen kommt es jedoch zu einem schweren Verlauf mit intensivmedizinischer Behandlung. Bei 1 von 30 stationär wegen COVID-19 behandelten Frauen kommt es zu einer Thromboembolie. Eine Infektion des Neugeborenen einer peripartal infizierten Mutter wird gelegentlich (etwa 1 von 20 Kindern) nachgewiesen und bleibt in der Regel ohne Konsequenz im Kurzzeit-Outcome. Viele weitere Fragestellungen wurden mithilfe von CRONOS beantwortet. Das weiter aktiv rekrutierende Register wird zukünftig mit mehr als 6000 Fällen auch tiefere Informationen zu verschiedenen Virusvarianten und zum Impfen liefern. CRONOS steht vorbildlich für eine beispiellose Kooperation von Ärztinnen und Ärzten der Frauenheilkunde in der Pandemie.

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Gestational diabetes mellitus and COVID-19: results from the COVID-19–Related Obstetric and Neonatal Outcome Study (CRONOS)

Cited by 45 publications

References 33 publications

Assessment of glucose levels in pregnant women with history of COVID-19 in a case-control study

Assessment of glucose levels in pregnant women with history of COVID-19 in a case-control study

Effect of COVID-19 during pregnancy: Studying the maternal and neonatal outcomes and assessing the placental changes related to SARS-CoV-2

COVID-19 in Schwangerschaft, Geburt und Wochenbett

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