Germacranolides from Mikania guaco

Rüngeler, Peter; Brecht, Volker; Tamayo‐Castillo, Giselle; Merfort, Irmgard

doi:10.1016/s0031-9422(00)00394-0

Cited by 30 publications

(28 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…15-isovaleryl-miguanin, 15-(2-methyl-butyryl)-miguanin, 1α-methoxy-15-isobutyryloxy-9-oxogermacra-4-trans,10(14),11(13)-trien-12,6α-olide, 14-hydroxy-15-isovaleryloxy-9-oxo-melampolide (32), 14-hydroxy-15-(2-methylbutyryloxy)-9-oxo-melampolide, 1β-methoxy-15-isovaleryloxy-9-oxo-germacra-4-trans,10(14),11(13)-trien-12,6α-olide, 1β-methoxy-15-(2-methylbutyryloxy)-9-oxo-germacra-4-trans,10(14),11(13)-trien-12,6α-olide, 1α-methoxy-15-isovaleryloxy-9-oxo-germacra-4-trans,10(14),11(13)-trien-12,6α-olide, 1β-methoxy-15-isobutyryloxy-9-oxo-germacra-4-trans,10(14),11(13)-trien-12,6α-olide (33), 1α-methoxy-15-(2-methylbutyryloxy)-9-oxogermacra-4-trans,10(14),11(13)-trien-12,6α-olide Rüngeler et al, 2001;Castro et al, 1989 M. thapsoides Corrientes Province, Argentina aerial parts 1(10)E-(3S,4R,5R,7S,8S)-14-acetyloxy-3,4-epoxy-5-hydroxy-15-senecioyloxygermacra-1(10),11(13)-dien-8,12-olide (34), 1(10)E-(4R,5R,7S,8S)-4,5-epoxy-14-oxo-15-senecioyloxygermacra-1(10),11(13)-dien-8,12-olide, 1(10)E-3Z-(5R,7S,8S)-14-acetyloxy-5-hydroxy-15-senecioyloxygermacra-1(10),3,11(13)-trien-8,12-olide, 1(10)E-(3S,4R,5R,7S,8S)-14-acetyloxy-3,4-epoxy-5-hydroxy-15-isovaleroyloxygermacra-1(10),11(13)-dien-8,12-olide (35), 1(10)E-3Z-(5R,7S,8S)-14-acetyloxy-5-hydroxy-15-isovaleroyloxygermacra-1(10),3,11(13)-trien-8,12-olide, 1(10)E-4Z-(7S,8S)-14-oxo-15-senecioyloxygermacra-1(10),4,11(13)-trien-8,12-olide, 1(10)E-4Z-(7S,8S)-14-oxo-15-isovaleroyloxygermacra-1(10),4,11(13)-trien-8,12-olide, 1(10)E-(3S,4R,5R,7S,8S)-3,4-epoxy-5,14-dihydroxy-15-senecioyloxygermacra-1(10),11 (13) (Alves et al, 1995) and M. glomerata (Barbosa et al, 1994), which is characterized by its trypanocidal activity. Also, the kaurenoic acid has other important activities such as antimicrobial, antinociceptive, anti-inflammatory and smooth muscle relaxant (Costa-Lotufo et al, 2002;Wilkens et al, 2002;Cunha et al, 2003;Gasparetto et al, 2012).…”

Section: Sesquiterpenes and Terpenes Diterpenes And Sesquiterpenes Lmentioning

confidence: 99%

Genus Mikania: chemical composition and phytotherapeutical activity

Rufatto¹,

Gower²,

Schwambach³

et al. 2012

Rev. bras. farmacogn.

View full text Add to dashboard Cite

Abstract:The genus Mikania ranks high in the list of best-selling natural products in the world. Its main distribution is in South America, but some species are found in Asia, North America and Africa. It is used for treating fever, rheumatism, colds and respiratory diseases, as well as snake bites and scorpion stings, due to its broad spectrum of action. There are approximately 430 species of this genus and only 12% have been studied, highlighting their chemical and pharmacological diversity. The main chemical groups are: coumarins and derivatives, sesquiterpenes, sesquiterpenes lactones, diterpenes, phytosterols/terpenoids and flavonoids. This review aims to supply useful references for scientists interested in natural products and the search for new compounds, from over the 300 already described for the genus.

show abstract

Section: Sesquiterpenes and Terpenes Diterpenes And Sesquiterpenes Lmentioning

confidence: 99%

Genus Mikania: chemical composition and phytotherapeutical activity

Rufatto¹,

Gower²,

Schwambach³

et al. 2012

Rev. bras. farmacogn.

View full text Add to dashboard Cite

show abstract

“…This plant has antifungal, antimicrobial, bronchodilatory, antiallergic, antihemorrhagic, and anti-inflammatory properties 10 . Phytochemical studies have shown that Mikania contains terpenes, essential oils 11 , di-and sesquiterpene lactones 12 , flavonoids, and stigmasterol 13 , alcohols, acids, esters, aldehydes, organic esters and steroids. Regarding the safety of the extracts, phytomedicines and isolated compounds, guaco species did not present significant toxic and genotoxic effects in humans 14 .…”

Section: Introductionmentioning

confidence: 99%

Anti-hemorrhagic effect of hydro-alcoholic extract of the leaves of Mikania glomerata in lesions induced by Bothrops jararaca venom in rats

et al. 2014

View full text Add to dashboard Cite

Conception, design, intellectual and scientific content of the study; critical analysis; final approval. ABSTRACT PURPOSE:To investigate the effects of hydroalcoholic leaf extract of Mikania glomerata Spreng (Asteraceae) on the activity of Bothrops jararaca snake venom in Wistar rats. METHODS:Fifty four rats Wistar were divided into six groups of nine animals in each: control treated with saline; control treated with B. jararaca venom; control treated with M. glomerata extract; B. jararaca venom incubated with M. glomerata extract at proportions of 1:1, 1:2, and 1:4. RESULTS: Histopathological and morphometric analysis showed that intradermal administration of snake venom incubated with the hydroalcoholic extract at proportions of 1:1, 1:2 and 1:4 promoted a significant reduction in the number of inflammatory cells and a marked decrease in edema after the third hour. There was also a significant reduction in the intensity of the hemorrhagic halo in animals receiving the snake venom incubated with the extract, with the observation of a progressive and parallel inhibition with increasing proportion of M. glomerata. CONCLUSION:The Mikania glomerata hydroalcoholic extract exerted effective anti-inflammatory and antihemorrhagic activity against the effects induced by Bothrops jararaca snake venom.

show abstract

“…de compostos químicos, principalmente flavonóides (Aguinaldo et al, 2003), terpenos (Fabri et al, 1997;Lobitz et al, 1997Lobitz et al, , 1998Veneziani et al, 1999;Reis et al, 2003;Nunez et al, 2004;Ohkoshi et al, 2004;Reis et al, 2008), lactonas sesquiterpênicas (Cuenca et al, 1993;Zamorano et al, 1994;Bardon et al, 1996;Veneziani et al, 1999;Rüngeler et al, 2001) e cumarinas (Biavati et al, 2004;Santos et al, 2006;Taleb-Contini et al, 2006;Saúde-Guimarães & Faria, 2007;Corrêa et al, 2008;Silva et al, 2008;Bolina et al, 2009).…”

unclassified

Contribuição ao estudo farmacognóstico de Mikania laevigata Sch. Bip. ex Baker (guaco), visando o controle de qualidade da matéria-prima

Budel¹,

Duarte²,

Kosciuv³

et al. 2009

Rev. bras. farmacogn.

View full text Add to dashboard Cite

RESUMO:O gênero Mikania, pertencente à família Asteraceae e à tribo Eupatoriae, tem cerca de 430 espécies distribuída principalmente na América do Sul. No Brasil, o gênero está representado por aproximadamente 171 espécies. Várias espécies do gênero Mikania de hábito trepador recebem a denominação vulgar de "guaco". Mikania laevigata Sch. Bip. ex Baker, conhecida como "guaco", "guaco-de-casa" e "guaco-do-mato", é uma espécie nativa do sul do Brasil. Suas folhas são empregadas na medicina tradicional como expectorante e como anti-reumáticas. É muito semelhante morfologicamente com M. glomerata, que é a espécie oficializada pela Farmacopéia Brasileira I. Alguns estudos de M. laevigata comprovaram atividades farmacológicas como, antiinflamatória, antimutagênica, antimicrobiana e antiulcerogênica. Objetivou-se estudar a morfologia externa e a anatomia do caule e da folha de M. laevigata, com a finalidade de fornecer dados farmacognósticos referentes à identificação e à diferenciação dessa espécie das demais Mikania, visando o controle de qualidade da matéria-prima. O material botânico foi submetido às microtécnicas fotônicas e eletrônicas de varredura usuais. As características morfoanatômicas descritas para a folha e o caule de M. laevigata auxiliam na identificação da espécie.Unitermos: Asteraceae, Mikania laevigata, controle de qualidade.ABSTRACT: "Contribution to the pharmacognostic study of Mikania laevigata Sch. Bip. ex Baker "Guaco" for the quality control". The genus Mikania, belonging to the family Asteraceae and tribe Eupatoriae, has about 430 species mainly distributed in South America. In Brazil, the genus is represented by approximately 171 species. Various members of Mikania are lianas and commonly called "guaco". Mikania laevigata Sch. Bip. ex Baker, known as "guaco", "guaco-decasa" and "guaco-do-mato", is native to the South of Brazil. Its leaves are used in folk medicine as expectorant and antirheumatic. It is morphologically similar to M. glomerata, whose monograph is included in the Brazilian Pharmacopoeia 1st Ed. Some studies on M. laevigata have demonstrated pharmacological activities, such as anti-inflammatory, antimutagenic, antimicrobial and antiulcerogenic. This work has aimed to study the morpho-anatomy of the stem and the leaf of M. laevigata, in order to supply pharmacognostic information related to the identification of this species and distinction from other Mikania for quality control purposes. The botanical material was prepared according to standard light and scanning electronic micro techniques. The morphoanatomical characters described for the stem and the leaf contribute to the identification of this species.

show abstract

Germacranolides from Mikania guaco

Cited by 30 publications

References 32 publications

Genus Mikania: chemical composition and phytotherapeutical activity

Genus Mikania: chemical composition and phytotherapeutical activity

Anti-hemorrhagic effect of hydro-alcoholic extract of the leaves of Mikania glomerata in lesions induced by Bothrops jararaca venom in rats

Contribuição ao estudo farmacognóstico de Mikania laevigata Sch. Bip. ex Baker (guaco), visando o controle de qualidade da matéria-prima

Contact Info

Product

Resources

About