Geriatric drug therapy: Neglecting the inevitable majority

Stegemann, Sven; Ecker, Felix; Maio, Mario; Kraahs, Peter; Wohlfart, R.; Breitkreutz, Jörg; Zimmer, Andreas; Bar‐Shalom, Daniel; Hettrich, Patrick; Broegmann, Bianca

doi:10.1016/j.arr.2010.04.005

Cited by 135 publications

(98 citation statements)

References 109 publications

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“…As medicinal products containing the required dosage may not be available, the practice of splitting tablets, opening capsules, or mixing powders with foods or liquids may lead to dose inaccuracy and other consequences for the safety of the patient and the efficacy of the treatment (Visser et al, 2016). Similarly, other populations may have specific needs with respect to medicine administration (Grimsrud et al, 2015;Slavkova and Breitkreutz, 2015;Stegemann et al, 2010). Therefore, the development of drug delivery platforms that can help addressing the needs of specific patient populations is greatly needed.…”

Section: Odf: a Potential Formulation Strategy For Special Patient Pomentioning

confidence: 99%

Orodispersible films: Towards drug delivery in special populations

Scarpa

Stegemann

Hsiao

et al. 2017

International Journal of Pharmaceutics

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Section: Odf: a Potential Formulation Strategy For Special Patient Pomentioning

confidence: 99%

Orodispersible films: Towards drug delivery in special populations

Scarpa

Stegemann

Hsiao

et al. 2017

International Journal of Pharmaceutics

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“…The demographic trend in both developed and developing countries is moving towards a society with an increasing percentage of people above 65 years of age (1). More significant will be the shift in composition of the elderly population over the 4 decades towards more people above 80 years of age, attributed to increased life expectancy and the baby-boomer generation passing the age of 65 years.…”

Section: Introductionmentioning

confidence: 99%

Sensory Stimulation to Improve Swallowing Reflex and Prevent Aspiration Pneumonia in Elderly Dysphagic People

et al. 2011

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Abstract. Morbidity and mortality from aspiration pneumonia continues to be a major health problem in the elderly. A swallowing disorder, such as a delayed triggering of the swallowing reflex, exists in patients with aspiration pneumonia. We found that the swallowing reflex in elderly people was temperature-sensitive. The swallowing reflex was delayed when the temperature of the food was close to body temperature. The actual swallowing time shortened when the temperature difference increases. The improvement of swallowing reflex by temperature stimuli could be mediated by the temperature-sensitive transient receptor potential (TRP) channel. The administration of a pastille with capsaicin as an agonist stimulus of TRPV1, a warm-temperature receptor, decreased the delay in swallowing reflex. Food with menthol, an agonist of TRPM8, a cold-temperature receptor, also decreased the delay in swallowing reflex. Olfactory stimulation such as black pepper was useful to improve the swallowing reflex for people with low activity of daily living (ADL) levels or with decreased consciousness. Oral care also shortened the latent time of swallowing reflex presumably due to stimulating the nociception of the oral cavity. A combination of these sensory stimuli may improve the swallowing disorders and prevent aspiration pneumonia.

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“…Таким образом, множественные проблемы фар-макотерапии у пожилых пациентов требуют, чтобы «ле- карственная терапия в гериатрии начиналась с момента разработки и производства ЛС, их адекватного те-стирования в клинических исследованиях, рацио-нального и безопасного назначения, надежного и без-опасного введения и применения с использованием, в том числе, мониторинга эффективности ЛС» [38]. Бо-лее подробному обсуждению мер, направленных на повышение эффективности и безопасности фарма-котерапии у пожилых пациентов, будет посвящена от-дельная статья.…”

Section: заключениеunclassified