Geographic and species association of hepatitis B virus genotypes in non-human primates

Starkman, S.; Macdonald, D. M.; Lewis, John; Holmes, Edward C.; Simmonds, Peter

doi:10.1016/s0042-6822(03)00430-6

Cited by 72 publications

(82 citation statements)

References 34 publications

(90 reference statements)

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“…The latter finding supports our hypothesis of a strict virus-host coevolution within the apes, in contrast to recent cross-species transmission of foamy viruses in great apes. The latter would have resulted in a different tree topology, with mixtures of SFV from different species within the same cluster, as has been described for primate hepatitis B virus (35). Coevolution due to a single spatial separation event, however, is difficult to reconcile with the finding of a group of SFVora from mixed origin.…”

Section: Fig 2 (A)mentioning

confidence: 96%

“…In addition, transfer of viruses between gibbons and orangutans has recently been suggested for the hepatitis B virus (35). In order to make a comprehensive analysis of the evolutionary relationships between these viruses, we amplified and sequenced additional SFV sequences from blood samples of various ape species.…”

Section: Fig 2 (A)mentioning

confidence: 99%

“…Studies of retroviruses (8, 9, 13, 19-22, 30, 38, 39, 43, 46) and hepatitis B viruses (16,35) have provided important information concerning ancient cross-species transmissions and virus-host coevolution in primates. Our phylogeographic analysis of SFVora provides insights in the orangutan's evolution and historical distributions, lending support for the hypothesis concerning ancient migrations of orangutans.…”

Section: Fig 2 (A)mentioning

confidence: 99%

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The Phylogeography of Orangutan Foamy Viruses Supports the Theory of Ancient Repopulation of Sumatra

Verschoor

Langenhuijzen

Bontjer

et al. 2004

J Virol

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Section: Fig 2 (A)mentioning

confidence: 96%

Section: Fig 2 (A)mentioning

confidence: 99%

Section: Fig 2 (A)mentioning

confidence: 99%

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The Phylogeography of Orangutan Foamy Viruses Supports the Theory of Ancient Repopulation of Sumatra

Verschoor

Langenhuijzen

Bontjer

et al. 2004

J Virol

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“…The presence of EVEs has helped provide a time scale of hepadnavirus evolution, particularly as some of the endogenization events may have occurred as early as 200 million years ago (15). Hence, although there is clear evidence for some cross-species transmission (20), current data suggest that hepadnavirus evolution largely follows a pattern of virus-host codivergence that extends to at least the origin of the ray-finned fish.…”

mentioning

confidence: 95%

Distinct Viral Lineages from Fish and Amphibians Reveal the Complex Evolutionary History of Hepadnaviruses

Dill

Camus

Leary

et al. 2016

J Virol

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Hepadnaviruses (hepatitis B viruses [HBVs]) are the only animal viruses that replicate their DNA by reverse transcription of an RNA intermediate. Until recently, the known host range of hepadnaviruses was limited to mammals and birds. We obtained and analyzed the first amphibian HBV genome, as well as several prototype fish HBVs, which allow the first comprehensive comparative genomic analysis of hepadnaviruses from four classes of vertebrates. Bluegill hepadnavirus (BGHBV) was characterized from in-house viral metagenomic sequencing. The African cichlid hepadnavirus (ACHBV) and the Tibetan frog hepadnavirus (TFHBV) were discovered using in silico analyses of the whole-genome shotgun and transcriptome shotgun assembly databases. Residues in the hydrophobic base of the capsid (core) proteins, designated motifs I, II, and III, are highly conserved, suggesting that structural constraints for proper capsid folding are key to capsid protein evolution. Surface proteins in all vertebrate HBVs contain similar predicted membrane topologies, characterized by three transmembrane domains. Most striking was the fact that BGHBV, ACHBV, and the previously described white sucker hepadnavirus did not form a fish-specific monophyletic group in the phylogenetic analysis of all three hepadnaviral genes. Notably, BGHBV was more closely related to the mammalian hepadnaviruses, indicating that cross-species transmission events have played a major role in viral evolution. Evidence of cross-species transmission was also observed with TFHBV. Hence, these data indicate that the evolutionary history of the hepadnaviruses is more complex than previously realized and combines both virus-host codivergence over millions of years and host species jumping. IMPORTANCEHepadnaviruses are responsible for significant disease in humans (hepatitis B virus) and have been reported from a diverse range of vertebrates as both exogenous and endogenous viruses. We report the full-length genome of a novel hepadnavirus from a fish and the first hepadnavirus genome from an amphibian. The novel fish hepadnavirus, sampled from bluegills, was more closely related to mammalian hepadnaviruses than to other fish viruses. This phylogenetic pattern reveals that, although hepadnaviruses have likely been associated with vertebrates for hundreds of millions of years, they have also been characterized by species jumping across wide phylogenetic distances. The Hepadnaviridae are characterized by extremely small (3-to 3.3-kbp), partially double-stranded DNA (dsDNA) genomes. The viral particles are spherical, with a diameter of approximately 42 nm, each containing a single copy of the genome covalently linked to the viral reverse transcriptase (RT), which provides DNA polymerase activity (1-3). The hepadnaviruses are unique among animal viruses in that they replicate their DNA by reverse transcription of an RNA intermediate and comprise the only group VII animal virus (dsDNA-RT virus) of the Baltimore system, which classifies viruses according to their genome composit...

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“…1 The distribution of HBV genotypes varies with geographical location 2 and ethnic group. 3,4 Heterogeneity of HBV may result in differences in the clinical outcomes of patients infected with HBV, such as the time to hepatitis B e antigen (HBeAg) seroconversion, 5,6 the severity of liver damage and their response to antiviral treatment. 7 Thus, knowledge of all the HBV genotypes with which patients in a particular district are infected is important for the proper and effective management of HBV.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Hepatitis B Virus Genotypes and their Relationship to Clinical Laboratory Outcomes in Tibetan and Han Chinese

Ding

Wang

et al. 2010

J Int Med Res

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Geographic and species association of hepatitis B virus genotypes in non-human primates

Cited by 72 publications

References 34 publications

The Phylogeography of Orangutan Foamy Viruses Supports the Theory of Ancient Repopulation of Sumatra

The Phylogeography of Orangutan Foamy Viruses Supports the Theory of Ancient Repopulation of Sumatra

Distinct Viral Lineages from Fish and Amphibians Reveal the Complex Evolutionary History of Hepadnaviruses

Prevalence of Hepatitis B Virus Genotypes and their Relationship to Clinical Laboratory Outcomes in Tibetan and Han Chinese

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