Prevalence of Hepatitis B Virus Genotypes and their Relationship to Clinical Laboratory Outcomes in Tibetan and Han Chinese

Li, D. D.; Ding, Luming; Wang, J.; Q, Meilang; Lu, Xiaojun; Song, Xingbo; Tao, Chuanmin; Ying, Binwu; Wang, L. L.

doi:10.1177/147323001003800122

Cited by 10 publications

(8 citation statements)

References 20 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, many studies have demonstrated that different genotypes have different clinical features and outcomes, and therefore detection is extremely important in the evaluation of prognosis and treatment 18,30,31 . In addition, as infectious agents, HBV genotype distribution has geographical features 15–17,32,33 . Based on the large-scale analysis in this study, genotype B was found predominant in Shenzhen, and genotype C was also common, whereas genotype D was rare.…”

Section: Discussionmentioning

confidence: 99%

“…Different genotypes distribute differently worldwide, whereas in China, there is a prevalence of genotypes B, C, and D 15,16 . Many studies have concluded that the prevalence of HBV genotypes exhibit different clinical features, which suggests it was a determinant of the outcome after acute HBV infection and of chronic HBV infection 17,18 . HBV genotypes were also demonstrated to correlate with the diversity of liver disease and the oxidative damage degree in patients with HBV-induced liver disease 19,20 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of Hepatitis B Virus Infection in Shenzhen, China, 2015–2018

Tao

Zhang

Yue

et al. 2019

Sci Rep

View full text Add to dashboard Cite

China has nearly 10% of the general HBV carrier population in the world; this infection is the most common cause of chronic liver disease. Understanding HBV epidemiology is essential for future infection control, evaluation, and treatment. This study determined the prevalence of HBV infection in Shenzhen by serological testing and analysis in 282,166 HBV screening cases for the following: HBcAb, indicative of previous HBV infection; HBsAg, indicative of chronic (current) infection; HBsAb, indicative of immunity from vaccination; and 34,368 HBV etiological screening cases for HBV-DNA, indicative of virus carriage, in which 1,204 cases were genotyped and mutation analyzed for drug-resistance evaluation. Shenzhen was a highly endemic area of HBV throughout the study period (prevalence 9.69%). HBV infections were almost entirely in the 20 and older age groups with a male-to-female ratio of 1.16:1 which is approximately the same as the male-to-female ratio of the general population in China. However, only 71.25% of the general population retained HBV immune protection. Genotype B and C were identified as the most common agents; recombinant B/C and B/D also existed; some cases, however, could not be genotyped. NAs resistant mutation occurrence patterns were multitudinous; single mutation patterns of rtM204I/V and rtL180M occurrences accounted for majority, followed by the combinational mutation pattern L180M + M204I/V. Drug-resistance was prevalent, mainly occurring in the cross resistance patterns LAM + LdT and LAM + LdT + ETV, and significantly more critical in males. These results demonstrate that all people free from HBV infection should obtain injections of the vaccine or booster shots, and conventional virologic detection in a clinical laboratory center should incorporate genotype and mutation alongside the serological factors for etiology and develop better classification methods, such as sequencing.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevalence of Hepatitis B Virus Infection in Shenzhen, China, 2015–2018

Tao

Zhang

Yue

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…In highly endemic countries, particularly in Asia where different HBV genotypes and subgenotypes co-circulate, mixed infections [21], [22], [23], [24] and recombinations have been described [3], [25], [26], [27], [28], [29], [30], [31]. For instance, in China almost 50% of infections are mixed [22] and mixed infections have also been reported from Thailand [32].…”

Section: Introductionmentioning

confidence: 99%

A High Variability of Mixed Infections and Recent Recombinations of Hepatitis B Virus in Laos

et al. 2012

View full text Add to dashboard Cite

In Lao PDR, where more than 8% of the population are chronic carriers of HBsAg, multiple genotypes and subgenotypes co-circulate and are prone to generate recombinant viruses. Phylogenetic analyses of multiple clones per donor revealed mixed infections of subgenotypes B1, B2, B4, C1, C5, I1 and I2 in almost 6% of HBsAg positive rejected blood donors. Recombination analyses and distance calculations furthermore showed that about 65% (17/26) of the mixed infected donors showed recombinations in the S-gene alone, involving the predominant genotypes B and C. These results suggest that, at least in Laos, hepatitis B virus (HBV) mixed infections lead to frequent recombinations. In many donors with recombinant strains, the recombinant fragment and a non-recombinant strain of the same genotype co-existed (127/185 analysed recombinant fragments). For a large proportion of these (60/127), the most closely related known virus was found, although not always exclusively, in the same donor. Recombinant virus strains are largely distinct. This is reflected in an unexpected diversity in recombination breakpoints and the relatively rare recombinations with identical recombination patterns of the same genotypes in different donors. Recent recombination events would explain the limited spread of each of the recombinants. Using a published mutation rate of 4.2×10−5 mutations per site and year, the observed minimum genetic distances of 0–0.60% between parent strain and recombinant fragment would correspond to 0–71 years of evolution from a most recent common ancestor (MRCA). Thus several lines of evidence are suggestive of recent independent recombination events, a proportion of these even occurring within the same donors. In conclusion, our analyses revealed a high variability of mixed infections as a very probable breeding ground of multiple variable recombination events in Laos that so far have not led to new dominant strains.

show abstract

“…It has been reported that 62.2% were found genotype D, 13% were found genotype A and 12%. :Mixed genotype D+A was found in 12% of acute patients, 5.6% of chronic patients and 5.6% of carriers ( 43 ), 85.1% were genotyped as type D/E , 4.4% were genotyped as type A, 1.4% were genotyped as type C, and 0.7% were genotyped as type F ( 44 ) and other study was indicated the HBV genotype frequencies were: B, 57.9%; C, 16.0%; and BC, 26.1% ( 45 ). A study conducted among injecting drug users showed that the presence of genotype Din 62%, genotype A in 9% while 29% individuals were found to be infected with a mixture of genotype A and D ( 46 ).…”

Section: Discussionmentioning

confidence: 96%

Prevalence and Genotypes of Hepatitis B Virus Infection in Patients Underwent Coronary Angiography and Coronary Artery Bypass Grafting in Mazandaran Heart Center, Sari, Iran

Mousavi

Ziabakhsh-Tabary

Ghaemiyan

et al. 2014

Med Arh

View full text Add to dashboard Cite

Background:Hepatitis B virus (HBV) infection is a major global health problem in the worldwide that associated with significant morbidity and mortality in cardiac surgery. The available data on HBV distribution and genotyping of HBV are very heterogeneous. Therefore in this study, we tried to indicate the prevalence of HBV infections in cardiac catheterization patients referred to health centers in the north of Iran and identified the HBV genotypes using polymerase chain reaction (PCR).Methods:In this cross-sectional study, we studied 2650 patients who underwent selective coronary artery angiography and coronary artery bypass grafting in Mazandaran heart center, Sari, Iran from 2011 to 2013. All serum samples were examined to detect HBsAg by ELISA test. HBV-DNA was extracted from HBsAg positive samples using Mini Elute Kit from Qiagen and determined the genotypes of HBV by PCR using the Master Mix kit with Taq-DNA polymerase enzyme and with type of specific primers. All samples were examined in the virology laboratory of Sari Medical School.Results:The mean age of patients was 59.7±10.9 (range, 20 to 81) year that 1590 (60%) patients were male and 1060 (40%) were female. Seventeen cases (0.08 %) were found with hepatitis B virus infection, and the highest rates of infection were reported among those aged 40–60 years old in this study. We found genotype D the predominant type in this study.Conclusion:This study indicates that the prevalence of HBV endemicity in the north of Iran is low and genotype D is the only genotype in patients infected with HBV.

show abstract

Prevalence of Hepatitis B Virus Genotypes and their Relationship to Clinical Laboratory Outcomes in Tibetan and Han Chinese

Abstract: This study was designed to investigate the prevalence of hepatitis B virus (HBV

Cited by 10 publications

References 20 publications

Prevalence of Hepatitis B Virus Infection in Shenzhen, China, 2015–2018

Prevalence of Hepatitis B Virus Infection in Shenzhen, China, 2015–2018

A High Variability of Mixed Infections and Recent Recombinations of Hepatitis B Virus in Laos

Prevalence and Genotypes of Hepatitis B Virus Infection in Patients Underwent Coronary Angiography and Coronary Artery Bypass Grafting in Mazandaran Heart Center, Sari, Iran

Contact Info

Product

Resources

About