Genus Lonicera: New drug discovery from traditional usage to modern chemical and pharmacological research

Ge, Lanlan; Xie, Qiujie; Jiang, Yuanyuan; Xiao, Lingyun; Wan, HL; Zhou, Boping; Wu, Sihan; Tian, Jun; Zeng, Xiaobin

doi:10.1016/j.phymed.2021.153889

Cited by 21 publications

(12 citation statements)

References 154 publications

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“…contains a variety of active ingredients, mainly including phenolic acids, avonoids, terpenoids, etc. 16 In China, Lonicera japonica Thunb. has long been used to treat diseases caused by bacterial and viral infections, such as respiratory infections, pneumonia, etc.…”

Section: Introductionmentioning

confidence: 99%

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Lonicera japonica Thunb. as a promising antibacterial agent for Bacillus cereus ATCC14579 based on network pharmacology, metabolomics, and in vitro experiments

Chen

et al. 2023

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

“…contains a variety of active ingredients, mainly including phenolic acids, flavonoids, terpenoids, etc. 16 …”

Section: Introductionmentioning

confidence: 99%

Lonicera japonica Thunb. as a promising antibacterial agent for Bacillus cereus ATCC14579 based on network pharmacology, metabolomics, and in vitro experiments

Chen

et al. 2023

RSC Adv.

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“…Lonicera japonica Thunb. contains many medicinal components such as flavonoids, phenolic acids, and iridoids [ 4 ]. Flavonoids are found to inhibit inflammatory cytokines and mediators [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Metabolomics Analysis of Different Tissues of Lonicera japonica Thunb. Based on Liquid Chromatography with Mass Spectrometry

Wang

et al. 2023

Metabolites

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Lonicera japonica Thunb. (LJT) has been widely used as medicines or food additives in Asian countries for thousands of years. The flower buds are often medicinally used, and the other tissues are ignored. However, flowers, leaves and stems have also been reported to have antimicrobial, anti-inflammatory and antioxidant effects. In the current study, un-targeted metabolomics analysis was performed to investigate the metabolic difference among different tissues (flowers, flower buds, stems and leaves) of LJT based on liquid chromatography with mass spectrometry. A total of 171 metabolites were identified, including 28 flavonoids, 35 phenolic acids, 43 iridoids, 9 amino acids, 6 nucleotides, 16 fatty acids, 22 lipids and 12 others. Four new secondary metabolites were discovered. Some flavonoids and iridoids were not detected in leaves and stems. Principal component analysis showed significant differences among four different tissues. Some 27, 81, 113 differential metabolites were found between flowers/flower buds, leaves/flower buds, stems/flower buds, respectively. Primary metabolites showed a higher content in the flowers and flower buds. For the flavonoids, flavones were mainly accumulated in the leaves, flavonols were mainly accumulated in the flower buds, and acylated flavonol glucosides were mainly accumulated in the flowers. Most phenolic acids showed a higher content in the flowers or flower buds, while phenolic acid-glucosides showed significantly higher content in the flower buds. The most abundant iridoids in the LJT also showed a higher content in the flowers and flower buds. These results can provide new insights into the understanding of the metabolites changes in different tissues, and lay a theoretical foundation for the comprehensive utilization of LJT.

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“…Lonicera japonica Thunb (Called Jinyinhua in Chinese) is a medicine food homology herb with a wide range of pharmacological effects, such as anti-inflammatory, antibacterial, antiviral, antioxidant, etc. (Shang et al, 2011;Ge et al, 2022). Notably, Lonicera japonica extract was found to alleviate OVA-induced asthma or allergic rhinitis in mice (Hong et al, 2013;Lin et al, 2019;Li et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Lonicerin attenuates house dust mite-induced eosinophilic asthma through targeting Src/EGFR signaling

et al. 2022

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Eosinophilic asthma is the predominant phenotype of asthma, and although these patients are sensitive to glucocorticoid therapy, they also experience many side effects. Lonicerin is a kind of bioflavonoid isolated from the Chinese herb Lonicera japonica Thunb, which has anti-inflammatory and immunomodulatory effects. The aim of this study was to elucidate the effects of lonicerin on eosinophilic asthma and its potential mechanisms. Here, we established a house dust mite (house dust mite)-induced eosinophilic asthma model in BALB/c mouse, and evaluated the effects of lonicerin on it. Our results showed that lonicerin significantly reduced airway hyperresponsiveness the number of inflammatory cells (especially eosinophils) and the elevation of interleukin (IL)-4, IL-5, IL-13 and eotaxin in bronchoalveolar lavage fluid (BALF) supernatants of mice. Additionally, lonicerin also eminently blunted inflammatory infiltration and mucus secretion, as well as mRNA levels of Mucin 5AC (MUC5AC) in lung tissue. Furthermore, results of network pharmacology and molecular docking revealed that Src kinase and epidermal growth factor receptor may be the potential targets responsible for the effects of lonicerin. Finally, in vivo experiments confirmed that lonicerin inhibited activation of the Src/EGFR pathway by decreasing their phosphorylation. Taken together, the present study demonstrated that lonicerin could suppress HDM-induced eosinophilic asthma in mice through inhibiting the activation of Src/EGFR pathway, which also provides a basis for further research as a new potentially therapeutic agent for eosinophilic asthma and its underlying mechanisms in the future.

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Genus Lonicera: New drug discovery from traditional usage to modern chemical and pharmacological research

Cited by 21 publications

References 154 publications

Lonicera japonica Thunb. as a promising antibacterial agent for Bacillus cereus ATCC14579 based on network pharmacology, metabolomics, and in vitro experiments

Lonicera japonica Thunb. as a promising antibacterial agent for Bacillus cereus ATCC14579 based on network pharmacology, metabolomics, and in vitro experiments

Metabolomics Analysis of Different Tissues of Lonicera japonica Thunb. Based on Liquid Chromatography with Mass Spectrometry

Lonicerin attenuates house dust mite-induced eosinophilic asthma through targeting Src/EGFR signaling

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