Lonicera japonica Thunb. as a promising antibacterial agent for Bacillus cereus ATCC14579 based on network pharmacology, metabolomics, and in vitro experiments

Xu, Nan; Du, Lizhong; Chen, Y. Eugene; Zhang, Jinhao; Zhu, Q. M.; Chen, Rong; Peng, Guoping; Wang, Qiming; Yu, Hua‐Zhong; Rao, Liqun

doi:10.1039/d3ra00802a

Cited by 4 publications

(2 citation statements)

References 44 publications

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“…Luteolin (3,4,5,7-tetrahydroxy flavone, PubChem CID: 5280445, CAS No: 491-70-3), with the molecular formula of C 15 H 10 O 6 (Figure 1), is a significant flavone substance that was mainly extracted from various TCM such as Lonicera japonica Thunb. and Perilla/rMtescews (L.) Britt (Gaihre et al, 2022;Xu et al, 2023). Currently, luteolin is deemed an important dietary supplement for nurturing human life and treating diseases such as inflammation, cardiovascular disease, and others with few or no side effects and thus plays a significant role in ameliorating human health (Assuncao et al, 2021;Huang et al, 2021;.…”

Section: Introductionmentioning

confidence: 99%

Luteolin, a flavone ingredient: Anticancer mechanisms, combined medication strategy, pharmacokinetics, clinical trials, and pharmaceutical researches

Shi,

Chen,

Gong

et al. 2023

Phytotherapy Research

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Current pharmaceutical research is energetically excavating the pharmacotherapeutic role of herb‐derived ingredients in multiple malignancies’ targeting. Luteolin is one of the major phytochemical components that exist in various traditional Chinese medicine or medical herbs. Mounting evidence reveals that this phytoconstituent endows prominent therapeutic actions on diverse malignancies, with the underlying mechanisms, combined medication strategy, and pharmacokinetics elusive. Additionally, the clinical trial and pharmaceutical investigation of luteolin remain to be systematically delineated. The present review aimed to comprehensively summarize the updated information with regard to the anticancer mechanism, combined medication strategies, pharmacokinetics, clinical trials, and pharmaceutical researches of luteolin. The survey corroborates that luteolin executes multiple anticancer effects mainly by dampening proliferation and invasion, spurring apoptosis, intercepting cell cycle, regulating autophagy and immune, inhibiting inflammatory response, inducing ferroptosis, and pyroptosis, as well as epigenetic modification, and so on. Luteolin can be applied in combination with numerous clinical anticarcinogens and natural ingredients to synergistically enhance the therapeutic efficacy of malignancies while reducing adverse reactions. For pharmacokinetics, luteolin has an unfavorable oral bioavailability, it mainly persists in plasma as glucuronides and sulfate‐conjugates after being metabolized, and is regarded as potent inhibitors of OATP1B1 and OATP2B1, which may be messed with the pharmacokinetic interactions of miscellaneous bioactive substances in vivo. Besides, pharmaceutical innovation of luteolin with leading‐edge drug delivery systems such as host–guest complexes, nanoparticles, liposomes, nanoemulsion, microspheres, and hydrogels are beneficial to the exploitation of luteolin‐based products. Moreover, some registered clinical trials on luteolin are being carried out, yet clinical research on anticancer effects should be continuously promoted.

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Section: Introductionmentioning

confidence: 99%

Luteolin, a flavone ingredient: Anticancer mechanisms, combined medication strategy, pharmacokinetics, clinical trials, and pharmaceutical researches

Shi,

Chen,

Gong

et al. 2023

Phytotherapy Research

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“…The flower, buds and caulis of JYH is determined as only plant sources widely used for in Chinese Pharmacopoeia [2]. Modern pharmacological studies have shown that JYH has broad pharmacological properties, including antioxidant, antiviral, antiseptic, and anti-inflammatory effects [3][4][5]. More than 300 medicine compounds have been reported in the buds and flowers of JYH and investigated their biosynthesis and pharmacological activities [6].…”

Section: Introductionmentioning

confidence: 99%

Metabolite profiles and antibacterial and antioxidant activities of leaf extracts of five Lonicera species: a comparative study

Feng,

Zhang,

Zhu

et al. 2023

Chem. Biol. Technol. Agric.

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Background Lonicera japonica Flos is widely used as a medicinal plant in China owing to its various pharmacological activities. However, little is known about the metabolic profile and antibacterial properties of the leaves of Lonicera species. The present study aimed to determine and compare the metabolite profiles and antibacterial and antioxidant activities of leaf extracts of five Lonicera species. Results 598 metabolites were identified based metabolomics using UHPLC-Q Exactive Orbitrap MS/MS in the five Lonicera species leaves. Among them, flavonoids and phenols compounds accounted for 13%. In Lonicera dasystyla, 110 differential metabolites were found compared to those in the other Lonicera species, of which flavonoids and phenols accounted for 20% and 10%, respectively. Compared to other Lonicera species leaves, the contents of total phenol, total flavonoid, antioxidant activities and anti-bacterial capacities were considerably higher in Lonicera hypoglauca and lower in L. dasystyla. The contents of total phenol and total flavonoid in L. hypoglauca were 95.86% and 201.64% higher than those in L. dasystyla. The RPA value in L. hypoglauca was 93.27% higher than the value of L. dasystyla, respectively. The content of 4, 5-dicaffeoylquninic acid in L. hypoglauca was 4.814 mg g−1, which was 302.85% higher than that of L. dasystyla. Besides, Chlorogenic acid was most high in leaves of L. japonica and reached 15 mg g−1, which was 209.34% higher than that of L. dasystyla. Moreover, correlation analysis showed most flavonoids, phenols, and coumarins were positively correlated with antioxidant activities and antibacterial capacities. Conclusions This study identified the difference of metabolites in leaves of five Lonicera species, antioxidant abilities and inhibition effects of leaf extracts on pathogens, which provides a potential information for further application of Lonicera leaves. Graphical Abstract

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The comparative analysis of Lonicerae Japonicae Flos and Lonicerae Flos: A systematical review

Chen,

Zou,

Jiang

et al. 2024

Journal of Ethnopharmacology

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Lonicera japonica Thunb. as a promising antibacterial agent for Bacillus cereus ATCC14579 based on network pharmacology, metabolomics, and in vitro experiments

Abstract: Lonicera japonica Thunb. has attracted much attention for its treatment of bacterial and viral infectious diseases, while its active ingredients and potential mechanisms of action have not been fully elucidated.

Cited by 4 publications

References 44 publications

Luteolin, a flavone ingredient: Anticancer mechanisms, combined medication strategy, pharmacokinetics, clinical trials, and pharmaceutical researches

Luteolin, a flavone ingredient: Anticancer mechanisms, combined medication strategy, pharmacokinetics, clinical trials, and pharmaceutical researches

Metabolite profiles and antibacterial and antioxidant activities of leaf extracts of five Lonicera species: a comparative study

The comparative analysis of Lonicerae Japonicae Flos and Lonicerae Flos: A systematical review

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