Genotype–environment interaction in schizophrenia-spectrum disorder

Tienari, Pekka; Wynne, Lyman C.; Sorri, Anneli; Lahti, Ilpo; Läksy, Kristian; Moring, Juha; Naarala, Mikko; Nieminen, Pentti; Wahlberg, Karl‐Erik

doi:10.1192/bjp.184.3.216

Cited by 307 publications

(198 citation statements)

References 24 publications

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“…There is evidence from animal work that neuregulin-1 and DISC1 may modify the consequences of prenatal immune activation 107,108 and that neuregulin 1 may modify the effect of exposure to social defeat. 107 There is also evidence from human studies that COMT may modify the effects of adolescent exposure to cannabis, 15 that individuals at high genetic risk for schizophrenia are particularly sensitive to the adverse effects of a negative family rearing environment, 109 and the effect of urbanicity is mediated by genetic liability to psychosis. 110 The urbanicity studies found that 60% to 70% of those in the sample who developed schizophrenia did so as a result of the synergistic action between urban dwelling and familial liability to psychosis.…”

Section: Gene-environment Intreractionmentioning

confidence: 99%

Predicting Risk and the Emergence of Schizophrenia

Clarke

Kelleher

Clancy

et al. 2012

Psychiatric Clinics of North America

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Section: Gene-environment Intreractionmentioning

confidence: 99%

Predicting Risk and the Emergence of Schizophrenia

Clarke

Kelleher

Clancy

et al. 2012

Psychiatric Clinics of North America

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“…Environmental factors are also important in the development of psychotic disorders, which is based on recent research of the association between psychotic disorders and cannabis use, childhood trauma and urbanicity (Cougnard et al, 2007). A study of Finnish adoptees found evidence for a genotypeenvironment interaction in schizophrenia-spectrum disorders (Tienari et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Age-specific familial risks of psychotic disorders and schizophrenia: A nation-wide epidemiological study from Sweden

Sundquist

2007

Schizophrenia Research

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Objective-This study analyzed men and women separately by age at hospital diagnosis of psychotic disorder or schizophrenia and by maternal or paternal disease after taking several possible confounders into account. Methods-The MultigenerationRegister, in which all men and women born in Sweden from 1932 onwards are registered together with their parents, was linked to hospital data. This yielded 21,199 male and 19,029 female cases of psychotic disorders in addition to 12,799 paternal and 23,021 maternal cases of psychotic disorders (including schizophrenia). Standardized incidence ratios (SIRs) were calculated as the ratio of observed and expected number of cases among men and women with mothers and/or fathers affected by psychotic disorders or schizophrenia, compared with men and women whose mothers and/or fathers were not affected by psychotic disorders or schizophrenia.Results-The overall significant SIRs among men and women with a mother, father or both parents hospitalized for psychotic disorder varied between 2.86 and 20.30. Maternal transmission of psychotic disorder was stronger than paternal, and the highest SIRs were found in the youngest age groups. Similar results were found when the subgroup schizophrenia was analyzed separately. Maternal or paternal schizophrenia implied higher risks for the offspring than maternal or paternal psychotic disorders.Conclusions-Hereditary factors have a strong influence on the onset of psychotic disorders and schizophrenia. Young people and individuals with both parents affected by these diseases need special attention as their SIRs were particularly increased.

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“…Recent studies have suggested that gene -environment interactions may be components of the overall risk. 4 Schizophrenia is thus largely genetically mediated but not genetically determined.…”

Section: Family Studies: Does Risk Aggregate In Relatives?mentioning

confidence: 99%