Age-specific familial risks of psychotic disorders and schizophrenia: A nation-wide epidemiological study from Sweden

Li, Xinjun; Sundquist, Jan; Sundquist, Kristina

doi:10.1016/j.schres.2007.09.027

Cited by 27 publications

(11 citation statements)

References 26 publications

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“… The 4-parameter model was fitted to published datasets for (a) French male ulcerative colitis [ 18 ]; (b) schizophrenia [ 30 ]; (c) multiple sclerosis [ 31 ]; (d) ankylosing spondylitis [ 32 ]. Published data are shown as red dots and the computed curves as blue lines.…”

Section: Resultsmentioning

confidence: 99%

Network Modeling of Crohn’s Disease Incidence

et al. 2016

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BackgroundNumerous genetic and environmental risk factors play a role in human complex genetic disorders (CGD). However, their complex interplay remains to be modelled and explained in terms of disease mechanisms.Methods and findingsCrohn's Disease (CD) was modeled as a modular network of patho-physiological functions, each summarizing multiple gene-gene and gene-environment interactions. The disease resulted from one or few specific combinations of module functional states. Network aging dynamics was able to reproduce age-specific CD incidence curves as well as their variations over the past century in Western countries. Within the model, we translated the odds ratios (OR) associated to at-risk alleles in terms of disease propensities of the functional modules. Finally, the model was successfully applied to other CGD including ulcerative colitis, ankylosing spondylitis, multiple sclerosis and schizophrenia.ConclusionModeling disease incidence may help to understand disease causative chains, to delineate the potential of personalized medicine, and to monitor epidemiological changes in CGD.

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Section: Resultsmentioning

confidence: 99%

Network Modeling of Crohn’s Disease Incidence

et al. 2016

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“…Several studies have reported a positive association between a range of defects in the mitochondrial genome and the development of schizophrenia [ 387 , 388 ]. There is also a growing body of evidence suggesting an increased maternal transmission of schizophrenia, which may indirectly indicate a potential role for mitochondrial inheritance in the etiology of the illness [ 389 , 390 ]. Numerous authors have demonstrated an association between certain mitochondrial haplotypes and disease risk, and the associations also extend to age of onset[ 390 ].…”

Section: Discussionmentioning

confidence: 99%

The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders

Morris

Berk

2015

BMC Med

203

152

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BackgroundMitochondrial dysfunction and defects in oxidative metabolism are a characteristic feature of many chronic illnesses not currently classified as mitochondrial diseases. Examples of such illnesses include bipolar disorder, multiple sclerosis, Parkinson’s disease, schizophrenia, depression, autism, and chronic fatigue syndrome.DiscussionWhile the majority of patients with multiple sclerosis appear to have widespread mitochondrial dysfunction and impaired ATP production, the findings in patients diagnosed with Parkinson’s disease, autism, depression, bipolar disorder schizophrenia and chronic fatigue syndrome are less consistent, likely reflecting the fact that these diagnoses do not represent a disease with a unitary pathogenesis and pathophysiology. However, investigations have revealed the presence of chronic oxidative stress to be an almost invariant finding in study cohorts of patients afforded each diagnosis. This state is characterized by elevated reactive oxygen and nitrogen species and/or reduced levels of glutathione, and goes hand in hand with chronic systemic inflammation with elevated levels of pro-inflammatory cytokines.SummaryThis paper details mechanisms by which elevated levels of reactive oxygen and nitrogen species together with elevated pro-inflammatory cytokines could conspire to pave a major road to the development of mitochondrial dysfunction and impaired oxidative metabolism seen in many patients diagnosed with these disorders.

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“…Indeed, results of twin, family, and molecular genetic studies strongly suggest that BPD [45, 46•] and psychotic disorders [47] are moderately to highly heritable.…”

Section: Association Between Maltreatment In Childhood and Psychotic mentioning

confidence: 99%

Borderline Personality Disorder and Psychosis: A Review

Barnow

Arens

Sieswerda

et al. 2010

Curr Psychiatry Rep

103

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Early views of borderline personality disorder (BPD) were based on the idea that patients with this pathology were "on the border" of psychosis. However, more recent studies have not supported this view, although they have found evidence of a malevolent interpersonal evaluation and a significant proportion of BPD patients showing psychotic symptoms. For example, in one study, 24% of BPD patients reported severe psychotic symptoms and about 75% had dissociative experiences and paranoid ideation. Thus, we start with an overview regarding the prevalence of psychotic symptoms in BPD patients. Furthermore, we report findings of studies investigating the role of comorbidity (eg, post-traumatic stress disorder) in the severity and frequency of psychotic symptoms in BPD patients. We then present results of genetic and neurobiological studies comparing BPD patients with patients with schizophrenia or nonschizophrenic psychotic disorders. In conclusion, this review reveals that psychotic symptoms in BPD patients may not predict the development of a psychotic disorder but are often permanent and severe and need careful consideration by clinicians. Therefore, adequate diagnosis and treatment of psychotic symptoms in BPD patients is emphasized.

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Age-specific familial risks of psychotic disorders and schizophrenia: A nation-wide epidemiological study from Sweden

Cited by 27 publications

References 26 publications

Network Modeling of Crohn’s Disease Incidence

Network Modeling of Crohn’s Disease Incidence

The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders

Borderline Personality Disorder and Psychosis: A Review

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