Molecular genetic studies of schizophrenia

Riley, Brien P.; Kendler, Kenneth S.

doi:10.1038/sj.ejhg.5201571

Cited by 160 publications

(139 citation statements)

References 89 publications

(52 reference statements)

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“…Most, if not all, promising candidate genes identified for schizophrenia in recent years had similar inconsistencies. [48][49][50][51][52][53] While it is possible that our findings are a false-positive, we believe that it is not very likely for several reasons. First, we performed false-positive rate evaluations with the Q-value method.…”

Section: Discussionmentioning

confidence: 79%

Association study of CSF2RB with schizophrenia in Irish family and case – control samples

et al. 2007

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Colony stimulating factor 2 receptor, beta (CSF2RB) is the shared subunit of receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2) and IL5, and is responsible for the initiation of signal transduction triggered by ligand binding. In our previous study, we showed the evidence that the IL3 gene is associated with schizophrenia and the associations observed are sex-specific and dependent on family history (FH). In this article, we studied 10 singlenucleotide polymorphisms in the CSF2RB gene in the Irish Study of High-Density Schizophrenia Families (ISHDSF) and the Irish Case -Control Study of Schizophrenia (ICCSS), and tested allele and haplotype associations with schizophrenia. Using the pedigree disequilibrium test, we found that two markers (rs11705394 and rs7285064) reached nominal significance. In sex-stratified analyses, for both the markers the association signals were mainly derived from male subjects. In the ICCSS sample, we found that several markers (rs2072707, rs2284031 and rs909486) showed sex-specific and FH-dependent associations with schizophrenia. In multimarker haplotype analyses, both ISHDSF and ICCSS samples showed globally significant associations in multiple linkage disequilibrium (LD) blocks sharing minimal LD. Since CSF2RB is essential for IL3 signaling, the findings that both IL3 and CSF2RB showed sex-specific and FH-dependent associations suggest that the IL3 pathway is involved in schizophrenia.

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Section: Discussionmentioning

confidence: 79%

Association study of CSF2RB with schizophrenia in Irish family and case – control samples

et al. 2007

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“…1,3 Chromosome 8 Linked loci with schizophrenia on this chromosome have been reported mainly on the short arm, 10,12,36 but a recent linkage disequilibrium screen in a relatively isolated population found evidence for linkage regions on both arms, suggesting a wider field of research for chromosome 8. 53 On 8p21-p12 lies the second of the two most strongly implicated susceptibility genes, neuregulin1 (NRG1), 45 although other reports could not replicate this finding. 54 NRG1 is associated with synaptic remodeling, neuronal migration and brain development and appears to influence glutamatergic function through regulation of NMDA receptors.…”

Section: Chromosomes 6 Andmentioning

confidence: 98%

“…44 One of the candidate genes identified so far with the strongest evidence in its favor, is the dystrobrevin-binding protein 1 gene which lies on 6p22. 45 Dysbindin is a component of the dystrophin protein complex in postsynaptic densities in the brain and has important roles in synaptic transmission and plasticity. 46 High-profile claims have also been made for the encoding of trace amine-associated receptor 6 gene, which maps on the 6q23.1 linkage region.…”

Section: Chromosomes 6 Andmentioning

confidence: 99%

The myelin-pathogenesis puzzle in schizophrenia: a literature review

2007

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Schizophrenia is a serious and disabling mental disorder with symptoms such as auditory hallucinations, disordered thinking and delusions, avolition, anhedonia, blunted affect and apathy. In this review article we seek to present the current scientific findings from linkage studies and susceptible genes and the pathophysiology of white matter in schizophrenia. The article has been reviewed in two parts. The first part deals with the linkage studies and susceptible genes in schizophrenia in order to have a clear-cut picture of the involvement of chromosomes and their genes in schizophrenia. The genetic linkage results seem to be replicated in some cases but in others are not. From these results, we cannot draw a fine map to a single locus or gene, leading to the conclusion that schizophrenia is not caused by a single factor/gene. In the second part of the article we present the oligodendrocyte-related genes that are associated with schizophrenia, as we hypothesize a potential role of oligodendrocyte-related genes in the pathology of the disorder.

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“…Mutsuddi et al concluded that the association between schizophrenia and DTNBP1 remains uncertain. In summary, current molecular methods, such as linkage and association analyses, have not clearly or indisputably identified definitive causative genes for schizophrenia (89). Therefore, it is necessary to develop new approaches to better understand the genetics of this disorder.…”

Section: Genetic Linkage and Association Studies In Schizophreniamentioning

confidence: 99%