Genotoxicity testing of a Salacia oblonga extract

Flammang, A.M.; Erexson, Gregory L.; Mecchi, Michael S.; Murli, Hemalatha

doi:10.1016/j.fct.2006.06.005

Cited by 22 publications

(14 citation statements)

References 11 publications

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“…As a result, mangiferin isolated from S. chinensis was evaluated in a series of genotoxicity studies to confirm the safety of its usage, and showed no mutagenicity up to 5 mg/plate when tested in S. typhimurium strains TA 97a, TA 98, TA 100, TA 102, and TA 1535, both with and without metabolic activation (Govindaraj et al, 2009). Therefore, our results are in agreement with the findings of Flammang et al (2006Flammang et al ( , 2007 and Govindaraj et al (2009).…”

Section: Discussionsupporting

confidence: 83%

“…However, studies with other species of the same genus have revealed such effects. Flammang et al (2006Flammang et al ( , 2007 demonstrated that the root extract of S. oblonga did not present mutagenicity using the Ames test in strains of Salmonella typhimurium and a test of chromosomal aberrations in cultured rat peripheral blood lymphocytes (in vivo study). Previous studies have demonstrated that various extracts of Salacia species (S. oblonga, S. chinensis, and S. prioidis) show potent α-glucosidase-inhibitory activity, which may be used as adjunctive therapy in the treatment of individuals with diabetes mellitus (Matsuda et al, 2002;Muraoka et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

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Assessment of genotoxic, cytotoxic, and protective effects of Salacia crassifolia (Mart. Ex. Schult.) G. Don. stem bark fractions in mice

Carneiro

Silva²,

Menezes³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Salacia crassifolia (Mart. Ex. Schult.) G. Don., popularly known in Brazil as "bacupari", "cascudo", and "saputá", is a shrub of the Celastraceae family that is unique to the Brazilian Cerrado region. In folk medicine, this plant has been mainly used to treat skin cancer and gastric ulcers. In the present study, the genotoxic, cytotoxic, antigenotoxic, and anticytotoxic effects of S. crassifolia stem bark fractions (hexane, ethyl acetate, and hydroalcoholic extracts) were evaluated using the mouse bone marrow micronucleus test. Our results showed that none of the S. crassifolia fractions led to a significant increase in the frequency of micronucleated polychromatic erythrocytes (MNPCE) (P > 0.05), suggesting the absence of genotoxicity. In the antigenotoxicity assessment, a significant decrease in the MNPCE frequency was observed in all fractions of this plant (P < 0.05), demonstrating its protective action against genotoxicity induced by mitomycin C (MMC), which was used as the positive control. Only the hexane fraction of S. crassifolia significantly decreased the poly-and normochromatic erythrocyte ratio (PCE/NCE) in all doses tested (P < 0.05), demonstrating its cytotoxic activity. In association with MMC, both ethyl acetate and hydroalcoholic fractions significantly increased the PCE/NCE ratio in almost all doses tested (P < 0.05), demonstrating the protective action of S. crassifolia against the cytotoxic effect of the positive control. In contrast, the hexane fraction presented a significant decrease in the PCE/NCE ratio in all treatments (P < 0.05), demonstrating an increase in this plant's cytotoxicity in mouse bone marrow cells.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Assessment of genotoxic, cytotoxic, and protective effects of Salacia crassifolia (Mart. Ex. Schult.) G. Don. stem bark fractions in mice

Carneiro

Silva²,

Menezes³

et al. 2013

Genet. Mol. Res.

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show abstract

“…Further hypoglycemic activity of herbal preparations containing Salacia species have also been reported in human studies (Kajimoto et al, 2000;Collene et al, 2005;Heacock et al, 2005;Jayawardena et al, 2005). Some toxicological studies have suggested minimal adverse effects of the herbal medicine in rodents (Wolf and Weisbrode, 2003;Flammang et al, 2006Flammang et al, , 2007Rong et al, in press). Recently, Salacia species have been extensively consumed in Japan, the United States and other countries as a food supplement for the prevention of obesity and diabetes, as well as being the subject of broad studies for diabetes management.…”

Section: Introductionmentioning

confidence: 85%

Salacia root, a unique Ayurvedic medicine, meets multiple targets in diabetes and obesity

Huang

Yamahara³

2008

Life Sciences

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“…has been confirmed in previous studies investigating subchronic toxicity, genotoxicity, etc. [64][65][66][67] The leaves of Salacia sp. are considered to be an attractive material as a foodstuff chiefly for two reasons.…”

Section: Effects Of the Water Extracts Of S Reticulata And S Oblongmentioning

confidence: 99%

Anti-Diabetic Activity of a Leaf Extract Prepared fromSalacia reticulatain Mice

Yoshino

Miyauchi

Kanetaka

et al. 2009

Bioscience, Biotechnology, and Biochemistry

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The effects of a water extract prepared from the leaves of Salacia reticulata on the absorption of sugars in normal and type 1 diabetic mice were investigated. The simultaneous oral administration of the extract at a dose of 1.0 mg/mouse with maltose or sucrose inhibited the postprandial elevation of the plasma glucose and insulin levels and intestinal alpha-glucosidase activities in mice. In addition, the supply of a 0.01% solution of the extract as drinking water prevented the elevation of the plasma glucose level and intestinal alpha-glucosidase activities in type 1 diabetic mice. This treatment also prevented the elevation of the plasma, pancreatic, and kidney lipid peroxide levels, lowering of the plasma insulin level, and elevation of the kidney aldose reductase activities in diabetic mice. These results suggest that the water extract of the leaves of S. reticulata could be a beneficial food material for the prevention of diabetes and obesity because of its multiple effects.

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Genotoxicity testing of a Salacia oblonga extract

Cited by 22 publications

References 11 publications

Assessment of genotoxic, cytotoxic, and protective effects of Salacia crassifolia (Mart. Ex. Schult.) G. Don. stem bark fractions in mice

Assessment of genotoxic, cytotoxic, and protective effects of Salacia crassifolia (Mart. Ex. Schult.) G. Don. stem bark fractions in mice

Salacia root, a unique Ayurvedic medicine, meets multiple targets in diabetes and obesity

Anti-Diabetic Activity of a Leaf Extract Prepared fromSalacia reticulatain Mice

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