Anti-Diabetic Activity of a Leaf Extract Prepared fromSalacia reticulatain Mice

Abstract

The effects of a water extract prepared from the leaves of Salacia reticulata on the absorption of sugars in normal and type 1 diabetic mice were investigated. The simultaneous oral administration of the extract at a dose of 1.0 mg/mouse with maltose or sucrose inhibited the postprandial elevation of the plasma glucose and insulin levels and intestinal alpha-glucosidase activities in mice. In addition, the supply of a 0.01% solution of the extract as drinking water prevented the elevation of the plasma glucose level and intestinal alpha-glucosidase activities in type 1 diabetic mice. This treatment also prevented the elevation of the plasma, pancreatic, and kidney lipid peroxide levels, lowering of the plasma insulin level, and elevation of the kidney aldose reductase activities in diabetic mice. These results suggest that the water extract of the leaves of S. reticulata could be a beneficial food material for the prevention of diabetes and obesity because of its multiple effects.

Proanthocyanidin Oligomers Isolated from Salacia reticulata leaves potently Inhibit Pancreatic Lipase Activity

“…Although the functions of KT stems and roots extracts have been actively studied, the functions of KT leaves have never been studied. Accordingly, our previous study showed that the aqueous extracts of KT leaves inhibited α‐glucosidase activity and decreased the plasma glucose levels of mice (Yoshino and others 2009). In the present study, the PLI activity of KT leaf extracts was evaluated and compared with that of KT stems extracts.…”

Screening of ethnic medicinal plants of South India against influenza (H1N1) and their antioxidant activity

“…Coscinium sps., and Salacia sps. were reported for their anti-diabetic and anti-inflammatory activities (Nayak et al, 2013;Ravishankar et al, 2013;Yoshino et al, 2009;Ismail et al, 1997). Chloroxylon sps., Cayratia sps.…”

Effect of NR-Salacia on post-prandial hyperglycemia: A randomized double blind, placebo-controlled, crossover study in healthy volunteers

“…[2324252627] Blocking of carbohydrate breakdown in the intestinal tract by various herbs such as Pelvetia , tochu-cha, welsh onion, and clove are well documented in the published literature. [28] Several clinical trials have been conducted in the past to determine the efficacy of herbal formulations that lower post-prandial blood sugar levels. [2930] Although popularity of herbal medicine is increasing, systematic reviews of scientific reports on the therapeutic usefulness and safety profile of herbal medications suggest the necessity of adequate data still to be generated on this aspect.…”