Salacia root, a unique Ayurvedic medicine, meets multiple targets in diabetes and obesity

Assessment of the Antidiabetic Potential of an Aqueous Extract of Honeybush (Cyclopia intermedia) in Streptozotocin and Obese Insulin Resistant Wistar Rats

“…In mice, persistent hyperglucagonaemia induced by glucagon-producing glucagonomas results in T2D (Y. Li et al, 2008). Glucagon secretion by the -cell is tightly regulated by insulin via insulin receptors at the surface of -cells.…”

“…These complex mixtures of often unspecified compounds are able to modulate multiple targets (Y. Li et al, 2008). Antidiabetic phenolic compounds in the extracts also have the ability to ameliorate oxidative stress (Han et al, 2007), an underlying mechanism to the pathogenesis of diabetes (Ceriello & Motz, 2004).…”

Preliminary Phytochemical Screening of Salacia Macrosperma

“…The roots are acrid, bitter, thermogenic, urinary, astringent, anodyne, anti-inflammatory and haemorrhoids [8]. The roots and stem have been widely used in treating diabetes and obesity, gonorrhoea, skin diseases and rheumatism [9,10]. It is also beneficial for the prevention of diabetes; obesity and lowers the lipid peroxide level ofthe kidney [11].…”

Inhibitory Effects of the Phytochemicals Partially Hydrolyzed Alginate, Leaf Extracts of Morus alba and Salacia Extracts on Dental Caries

“…The roots and stems of Salacia species plants have been used in the Ayurvedic system of Indian medicine to treat diabetes mellitus (DM) (Li et al, 2008). Salacia is a woody climbing plant belonging to the Celastrceae family that is found in limited regions of India and Sri Lanka.…”