Genotoxic Effects of Pentachlorophenol, Lindane, Transfluthrin, Cyfluthrin, and Natural Pyrethrum on Human Mucosal Cells of the Inferior and Middle Nasal Conchae

Tisch, M.; Faulde, Michael; Maier, H.

doi:10.1177/194589240501900206

Cited by 51 publications

(26 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the case presented here, we describe a subject developing permanent anosmia, preceded by nasal irritation and short lasting phantosmia and torqosmia, after working several hours in a room treated with an insecticide sprayed to control infestation of parasites. cells of human nasal mucosa has been observed [37]. These studies lend support to the hypothesis of the insecticide exposure as the primary cause for the permanent anosmia observed.…”

Section: Ijomeh 2012;25(4)supporting

confidence: 74%

Anosmia after exposure to a pyrethrin-based insecticide: A case report

Gobba

Abbacchini

2012

International Journal of Occupational Medicine and Environmental Health

View full text Add to dashboard Cite

We present the case of a subject developing anosmia, preceded by nasal transient irritation and short lasting phantosmia and torqosmia, upon re-entrance into a room treated with a pyrethrin-based insecticide. The concentration of the insecticide in the room is unknown, but relatively high levels are predicted basing upon the modality of exposure and by the irritation symptoms in the subject. Despite corticosteroids therapy, anosmia has persisted unmodified for more than three years; according to, and based on evidence in the literature on olfactory disturbance prognosis, anosmia in this patient is likely to be permanent. The significance of this case report is related to the current wide use of insecticides containing pyrethrin and pyrethroids and highlights the need for more adequate attention to lowering airborne concentrations of pyrethrins and pyrethroids prior to re-entering the treated rooms. In particular, in a closed space sprayed with pyrethrins and pyrethroids insecticide, any irritant symptoms and/or dysosmia should be immediately considered relevant warning signs, and must be avoided.

show abstract

Section: Ijomeh 2012;25(4)supporting

confidence: 74%

Anosmia after exposure to a pyrethrin-based insecticide: A case report

Gobba

Abbacchini

2012

International Journal of Occupational Medicine and Environmental Health

View full text Add to dashboard Cite

show abstract

“…The genotoxic and/or cytotoxic potential of some Type II pyrethroid insecticides such as cyfluthrin [Tisch et al, 2005], cypermethrin [Amer and Aboul-Ela, 1985;Bhunya and Pati, 1988;Amer et al, 1993;Chauhan et al, 1997Chauhan et al, , 1999Hadnagy et al, 1999;Institóris et al, 1999;Giri et al, 2003;Patel et al, 2006;Suman et al, 2006], deltamethrin [Agarwal et al, 1994;Surrallés et al, 1995;Gandhi et al, 1995;Villarini et al, 1998], fenvalerate [Pati and Bhunya, 1989;Puig et al, 1989;Surrallés et al, 1990;Caballo et al, 1992;Ghosh et al, 1992;Giri et al, 2002], and k-cyhalothrin [Campana et al, 1999;Ç elik et al, 2003, 2005a, 2005bNaravaneni and Jamil, 2005] has been shown in previous studies.…”

Section: Introductionmentioning

confidence: 99%

The in vitro genotoxic effects of a commercial formulation of α‐cypermethrin in human peripheral blood lymphocytes

Kocaman

Topaktaş

2008

Environ and Mol Mutagen

View full text Add to dashboard Cite

a-Cypermethrin, a highly active pyrethroid insecticide, is effective against a wide range of insects encountered in agriculture and animal husbandry. The potential genotoxicity of a commercial formulation of a-cypermethrin (Fastac 100 EC, containing 10% a-cypermethrin as the active ingredient) on human peripheral lymphocytes was examined in vitro by sister chromatid exchange (SCE), chromosomal aberrations (CAs), and micronucleus (MN) tests. The human lymphocytes were treated with 5, 10, 15, and 20 lg/ml of a-cypermethrin for 24-and 48-hr. a-Cypermethrin induced SCEs and CAs significantly at all concentrations and treatment times and MN formation was significantly induced at 5 and 10 lg/ml of a-cypermethrin when compared with both the control and solvent control. Binuclear cells could not be detected sufficiently in the highest two concentration of a-cypermethrin (15 and 20 lg/ml) for both the 24-and 48-hr treatment times. a-Cypermethrin decreased the proliferation index (PI) at three high concentrations (10, 15, and 20 lg/ml) for both treatment periods as compared with the control groups. In addition, acypermethrin reduced both the mitotic index (MI) and nuclear division index (NDI) significantly at all concentrations for two treatment periods. The PI and MI were reduced by a-cypermethrin in a concentration-dependent manner during both treatment times. In general, a-cypermethrin showed higher cytotoxic and cytostatic effects than positive control (MMC) at the two highest concentrations for the 24-and 48-hr treatment periods. The present study is the first to report the genotoxic and cytotoxic effects of commercial formulation of a-cypermethrin in peripheral blood lymphocytes. Environ. Mol. Mutagen. 50:27-36, 2009. V V C 2008 Wiley-Liss, Inc.

show abstract

“…The fact that PCE/NCE ratio decreased in tetramethrine group showed that the chemical affected the bone marrow cells. In parallel to results of the study conducted on the genotoxicity of pesticides in pyrethroide group [28,[30][31][32]. This study concluded that tetramethrine had a genotoxic effect; however, it had a limited effect depending on dosage.…”

Section: Discussionmentioning

confidence: 67%

“…In the study conducted by Tisch et al, to investigate the effect of transfluthrin in the mucosa cells of human nasal cavity, they determined that transfluthrin had a genotoxic effect [30]. Institoris et al, examined the genotoxic effects of permethrin on the bone marrow cells of male winstar rats and identified that numerical chromosome abnormalities increased in all the dosages used [31].…”

Section: Discussionmentioning

confidence: 99%

Protective role of caffeic acid phenethyl ester against tetramethrine-induced toxicity in mice

Nur¹,

Deveci²,

Ersan³

et al. 2016

Med-Science

View full text Add to dashboard Cite

The purpose of this study was to determine the biochemical, histopathological and genotoxic effects of tetramethrine, which is widely used in domestic and agricultural activities as well as identify the protective effect of caffeic acid phenethyl ester (CAPE). 30 Swiss albino laboratory mice (Mus musculus) were used in the study. 10 μM/kg tetramethrine, dissolving in 10 mM DMSO (Dimethyl sulfoxide), was intraperitoneally injected to the Tetramethrine group (n = 10). To the CAPE-Tetramethrine group, 10 µM / kg -1 CAPE, dissolving in 1% ethanol, was applied in three days before the experiment and then, CAPE and 10 μM / kg tetramethrine, dissolving in 10 mM DMSO, was intraperitoneally injected. No injection was made to the control group. At the end of the experiment, the rats anaesthetized with diethyl ether were killed by cervical dislocation and their livers and femur were removed for analysis. There was no statistical difference between three groups in terms of mitotic index (MI) and micronucleus frequency (P > 0.05). Chromosomal aberration frequency showed an increase in the other two groups compared to the control group (P < 0.05). Although severe degeneration and necrosis areas were identified in the liver, CAPE decreased the severity of degeneration in the Tetramethrine group. While Tetramethrine increased the malondialdehyde (MDA) level in the liver, CAPE decreased MDA and increased the GSH level. We think that CAPE may be used for therapeutic purposes in order to provide a limited protection against the tetramethrine-related detrimental effects in humans and other living organisms.

show abstract

Genotoxic Effects of Pentachlorophenol, Lindane, Transfluthrin, Cyfluthrin, and Natural Pyrethrum on Human Mucosal Cells of the Inferior and Middle Nasal Conchae

Cited by 51 publications

References 34 publications

Anosmia after exposure to a pyrethrin-based insecticide: A case report

Anosmia after exposure to a pyrethrin-based insecticide: A case report

The in vitro genotoxic effects of a commercial formulation of α‐cypermethrin in human peripheral blood lymphocytes

Protective role of caffeic acid phenethyl ester against tetramethrine-induced toxicity in mice

Contact Info

Product

Resources

About