Genome-wide DNA methylome alterations in acute coronary syndrome

Li, Dandan; Yan, Jing; Yuan, Ye; Wang, Cheng; Wu, Jia; Chen, Qingwen; Song, Jiuzhou; Wang, Junjun

doi:10.3892/ijmm.2017.3220

Cited by 14 publications

(10 citation statements)

References 59 publications

(49 reference statements)

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“…PYROXD1 is involved in the response to oxidative stress [ 27 ]. Recent studies report higher DNAm in this gene in acute coronary syndrome and brain white matter lesions in older populations [ 28 , 29 ]. Furthermore, a microarray-based post mortem analysis in human dorsal raphe nucleus tissue, a brain region pathophysiologically involved in serotonergic neurotransmission in MDD, showed a significant upregulation of the PYROXD1 transcript in MDD cases vs. controls, corresponding to higher protein production related to MDD [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder

et al. 2022

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Background Panic disorder (PD) is characterized by recurrent panic attacks and higher affection of women as compared to men. The lifetime prevalence of PD is about 2–3% in the general population leading to tremendous distress and disability. Etiologically, genetic and environmental factors, such as stress, contribute to the onset and relapse of PD. In the present study, we investigated epigenome-wide DNA methylation (DNAm) in respond to a cumulative, stress-weighted life events score (wLE) in patients with PD and its boundary to major depressive disorder (MDD), frequently co-occurring with symptoms of PD. Methods DNAm was assessed by the Illumina HumanMethylation450 BeadChip. In a meta-analytic approach, epigenome-wide DNAm changes in association with wLE were first analyzed in two PD cohorts (with a total sample size of 183 PD patients and 85 healthy controls) and lastly in 102 patients with MDD to identify possible overlapping and opposing effects of wLE on DNAm. Additionally, analysis of differentially methylated regions (DMRs) was conducted to identify regional clusters of association. Results Two CpG-sites presented with p-values below 1 × 10−05 in PD: cg09738429 (p = 6.40 × 10−06, located in an intergenic shore region in next proximity of PYROXD1) and cg03341655 (p = 8.14 × 10−06, located in the exonic region of GFOD2). The association of DNAm at cg03341655 and wLE could be replicated in the independent MDD case sample indicating a diagnosis independent effect. Genes mapping to the top hits were significantly upregulated in brain and top hits have been implicated in the metabolic system. Additionally, two significant DMRs were identified for PD only on chromosome 10 and 18, including CpG-sites which have been reported to be associated with anxiety and other psychiatric phenotypes. Conclusion This first DNAm analysis in PD reveals first evidence of small but significant DNAm changes in PD in association with cumulative stress-weighted life events. Most of the top associated CpG-sites are located in genes implicated in metabolic processes supporting the hypothesis that environmental stress contributes to health damaging changes by affecting a broad spectrum of systems in the body.

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Section: Discussionmentioning

confidence: 99%

Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder

et al. 2022

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“…In recent year, studies focusing on the relationship between epigenetics and CAD revealed that aberrant methylation of gene promoter might be implied in the etiology of CAD [6, 22]. As an important component of complement system, C3 may be involved in the occurrence and development of CAD by direct and indirect mechanisms.…”

Section: Discussionmentioning

confidence: 99%

A preliminary study showing no association between methylation levels of C3 gene promoter and the risk of CAD

et al. 2019

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ObjectiveCoronary artery disease (CAD) is a multi-factor disease. Complement component 3 (C3) plays an important role in the development of CAD. The present study investigated the association between DNA methylation status of C3 gene promoter and the risk of CAD.MethodsOne hundred CAD patients and 1 hundred age-and gender- matched controls were recruited in current study. Methylation levels in CpG island in C3 promoter were determined by the method of bisulfite amplicon sequencing.ResultsMethylation levels of four CpG sites in C3 promoter were measured. There were no significant difference in methylation level of each CpG site between CAD patients and controls. Average methylation rate was also calculated. No significant difference in average methylation rate was observed between CAD and control groups. Stratified analyses based on EH, DM and smoking status were carried out, no significant association between C3 promoter methylation levels and the susceptibility of CAD was observed. Furthermore, seven haplotypes were established and no significant difference in haplotypes was observed between CAD and control groups. However, our study showed that C3 DNA methylation levels were positively associated with LDL-C levels.ConclusionThe present study showed no association between methylation levels of C3 promoter and the risk of CAD. However, the methylation levels might be related to LDL-C levels.Electronic supplementary materialThe online version of this article (10.1186/s12944-018-0949-4) contains supplementary material, which is available to authorized users.

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“…In the study of genome-wide methylation in ACS, 19 hypermethylated loci and 17 hypomethylated genes that may be markers of ACS were identified, however, the association of methylation with nosology in the case-control study using methyl-specific PCR was confirmed only for the SMAD3 locus [55]. Another epigenome-wide study using the whole blood of 102 patients with ACS and 101 people in the control group identified 47 CpG sites associated with ACS.…”

Section: Dna Methylation and Ischemic Heart Diseasementioning

confidence: 99%

Role of DNA Methylation in Development of Cardiovascular Diseases, Resulting in a Sudden Cardiac Death (Review)

Иванова¹,

Maksimova²,

Gurazheva³

2022

Sovrem Tehnol Med

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An effective system to diagnose predisposition to development of sudden cardiac death (SCD) is required in order to determine the risk of developing a sudden fatal outcome well in advance of the onset thereof, including in people with asymptomatic cardiovascular disease, as well as to implement early preventive measures that can result in a decrease in the population mortality from cardiovascular diseases. Thus, the search for SCD risk markers becomes a topical issue for modern health care.According to recent studies, epigenetic mechanisms of heredity, and DNA methylation above all, play an important role in development of many diseases. The review provides the results of recent foreign and Russian studies on identification of a link between DNA methylation and development of cardiovascular diseases being the basis for SCD (IHD, cardiomyopathies, heart rhythm disturbances). The major part of the review is dedicated to studying DNA methylation in IHD, which is the most epigenetically explored nosology at the moment. Attention is also paid to studies of the DNA methylation role in development of acute coronary syndrome and myocardial infarction, which have development mechanisms similar to those of SCD. There were only few studies on identification of a link between DNA methylation and cardiomyopathies and cardiac arrhythmias conducted, however, an association of specific genes methylation with the explored nosologies was revealed. The review also provides pathogenetic substantiations of the possibilities to use epigenetic markers of cardiovascular diseases as SCD markers.Thus, it has been established that study of genes the methylation of which is associated with IHD (CTH, PLCB1, PTX3, MMP9, FN1, F2RL3, ABCB1, FOXP3, GDF15, IL6, CASR), with lipid metabolism disorders and atherosclerosis (CETP, CCL2, SREBF2, TIMP1), as well as with heart rhythm disturbances (SCN5A and KCNQ1), may be most promising in relation to SCD.

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Genome-wide DNA methylome alterations in acute coronary syndrome

Cited by 14 publications

References 59 publications

Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder

Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder

A preliminary study showing no association between methylation levels of C3 gene promoter and the risk of CAD

Role of DNA Methylation in Development of Cardiovascular Diseases, Resulting in a Sudden Cardiac Death (Review)

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