A preliminary study showing no association between methylation levels of C3 gene promoter and the risk of CAD

Cai, Gaojun; Huang, Zhiying; Liu, Yu; Li, Li

doi:10.1186/s12944-018-0949-4

Cited by 1 publication

(1 citation statement)

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“…In a rat model of IRI, Pratt et al (206) found aberrant methylation in the C3 promoter gene in response to 24 h of cold ischemia and a subsequent 2 h of reperfusion, indicating an increased C3 release, therefore an amplification of local complement activation following the oxidative stress. However, these studies neither demonstrate a correlation between C3 aberrant methylation and increased gene expression (207) nor provided clinical translation data (208).…”

Section: Complement and Epigenetic Changes In Agingmentioning

confidence: 99%

Inflammaging and Complement System: A Link Between Acute Kidney Injury and Chronic Graft Damage

et al. 2020

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The aberrant activation of complement system in several kidney diseases suggests that this pillar of innate immunity has a critical role in the pathophysiology of renal damage of different etiologies. A growing body of experimental evidence indicates that complement activation contributes to the pathogenesis of acute kidney injury (AKI) such as delayed graft function (DGF) in transplant patients. AKI is characterized by the rapid loss of the kidney’s excretory function and is a complex syndrome currently lacking a specific medical treatment to arrest or attenuate progression in chronic kidney disease (CKD). Recent evidence suggests that independently from the initial trigger (i.e., sepsis or ischemia/reperfusions injury), an episode of AKI is strongly associated with an increased risk of subsequent CKD. The AKI-to-CKD transition may involve a wide range of mechanisms including scar-forming myofibroblasts generated from different sources, microvascular rarefaction, mitochondrial dysfunction, or cell cycle arrest by the involvement of epigenetic, gene, and protein alterations leading to common final signaling pathways [i.e., transforming growth factor beta (TGF-β), p16ink4a, Wnt/β-catenin pathway] involved in renal aging. Research in recent years has revealed that several stressors or complications such as rejection after renal transplantation can lead to accelerated renal aging with detrimental effects with the establishment of chronic proinflammatory cellular phenotypes within the kidney. Despite a greater understanding of these mechanisms, the role of complement system in the context of the AKI-to-CKD transition and renal inflammaging is still poorly explored. The purpose of this review is to summarize recent findings describing the role of complement in AKI-to-CKD transition. We will also address how and when complement inhibitors might be used to prevent AKI and CKD progression, therefore improving graft function.

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Section: Complement and Epigenetic Changes In Agingmentioning

confidence: 99%