2020
DOI: 10.3389/fimmu.2020.00734
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Abstract: The aberrant activation of complement system in several kidney diseases suggests that this pillar of innate immunity has a critical role in the pathophysiology of renal damage of different etiologies. A growing body of experimental evidence indicates that complement activation contributes to the pathogenesis of acute kidney injury (AKI) such as delayed graft function (DGF) in transplant patients. AKI is characterized by the rapid loss of the kidney’s excretory function and is a complex syndrome currently lacki… Show more

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Cited by 62 publications
(46 citation statements)
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References 267 publications
(333 reference statements)
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“…Interestingly, the authors found that classical and alternative pathways were significantly higher in the elderly, in contrast to lectin pathway activation [115]. Besides physiological and chronological aging, premature aging induced by AKI episodes could be modulated by complementary inhibition [108]. In a pig model of I/R we demonstrated that C1-INHIBITOR (C1-INH), an endogenous regulator of classical and lectin pathway, was able to protect from tubular senescence preserving the level of anti-aging protein Klotho and reducing cell cycle arrest proteins levels [70,81].…”
Section: Complement System In the Elderlymentioning
confidence: 97%
See 1 more Smart Citation
“…Interestingly, the authors found that classical and alternative pathways were significantly higher in the elderly, in contrast to lectin pathway activation [115]. Besides physiological and chronological aging, premature aging induced by AKI episodes could be modulated by complementary inhibition [108]. In a pig model of I/R we demonstrated that C1-INHIBITOR (C1-INH), an endogenous regulator of classical and lectin pathway, was able to protect from tubular senescence preserving the level of anti-aging protein Klotho and reducing cell cycle arrest proteins levels [70,81].…”
Section: Complement System In the Elderlymentioning
confidence: 97%
“…Complement system, an essential player of innate immune system is recognized as pivotal in several kidney diseases from glomerulonephritis (Lupus Nephritis, C3 glomerulopathy, IgAN) to AKI and further progression to CKD [107,108].…”
Section: Complement System In the Elderlymentioning
confidence: 99%
“…The C4d deposition has been considered the gold standard for ABMR diagnosis for several years, indicating activation of Classical pathway of Complement; however, all Complement pathways have been proved to be involved in ABMR, leading to recruitment and activation of leukocytes such as Natural Killer cells, monocytes/macrophages, and lymphocytes [ 97 ].…”
Section: Armentioning
confidence: 99%
“…Immunosenescence describes the process of progressive deterioration of the immune functions during aging due to a several causes such as: (i) reduced NK cell-mediated cytotoxicity and perforin release, (ii) altered TLRs and NODs activation on monocytes, decreased phagocytosis, ROS generation; increased basal production of proinflammatory cytokines; (iii) less efficient antigen presentation and phagocytosis by dendritic cells; reduced secretion of IFNγ and IL-12, (iv) systemic inflammaging as a state of chronic, low grade inflammation and the (v) thymic involution leading to reduced naïve T cell and increased memory cells in the elderly ( 158 160 ). Dysregulated functions associated to immunosenescence can include reduced responses to vaccination, lower antitumor ability of CD4, CD8 T cells and APC, increased systemic inflammation, as well as autoimmunity ( 79 ).…”
Section: Immunosenescence and Cell Cycle Arrest As Biomarkers Of Icismentioning
confidence: 99%