Genome-Wide Association Study on Male Genital Shape and Size in Drosophila melanogaster

Takahara, Baku; Takahashi, Kazuo H.

doi:10.1371/journal.pone.0132846

Cited by 27 publications

(37 citation statements)

References 32 publications

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“…Male genital structure in general is known to have low phenotypic and genetic variations (Takahara & Takahashi 2015). The detected striking divergences in the speciation traits across species suggests directional sexual selection acting on these structures.…”

Section: Shape Divergencementioning

confidence: 98%

Revision of Drusinae subfamily (Trichoptera, Limnephilidae): divergence by paraproct and paramere: speciation in isolation by integration

Oláh¹,

Beshkov²,

Chvojka³

et al. 2017

Opusc Zool

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Abstract.In the last few years we have described over 70 new incipient sibling limnephild species applying the discovered Trichoptera speciation traits of the paraproct and paramere for species recognition and delimitation. In this revision on Drusinae subfamily, comprising 177 species, we have applied these subtle, but rapid and stable speciation traits and described 49 new sibling species from the "well studied" European mountain ranges. Discussing the theoretical background we have elaborated and adapted a new character state ranking system of phenomics to revise the long-neglected taxonomy of the Drusinae subfamily and synonymised the Cryptothrix, Monocentra, Metanoea, Leptodrusus, Anomalopterygella, Hadimina genera with the Drusus genus. These old genera of artificial constructs were established exclusively by divergences of secondary sexual traits known already to have only species level ranking value. According to our new character ranking system in the Drusinae subfamily, beside the Drusus genus, only the Ecclisopteryx genus has been retained having robust generic level divegences of paraproct loss and ancestral duplication of spine organising centre on the paramere pattern. Speciation trait function of the peg-packed surface on the paraproct head in Drusus genus moved to the gonopod apices and integrated into variously shaped stimulatory organ in the Ecclisopteryx genus. In the Drusus genus the ancestral divergence of the single spine organising centre has integrated 11 species groups with remarkably stable paramere spine pattern. Based upon ancestral divergences in the paraproct architecture we have differenciated 28 species complexes inside the 11 species groups. The delineation of the 163 mostly incipient siblings species, inside the 28 species complexes with 44 new Drusus species, was based primarily on the divergences of speciation trait, that is in the stimulatory head shape of the apical arms on the dorsal branches of the paraproct. In the Ecclisopteryx genus with 14 species we have established two independent lineages both with a single species, as well as two species complexes with five new species applying the speciation trait of the genus, that is the shape divergence of the stimulatory organ on the dorsoapical surface of the gonopods.Based on the Darwinian natural selection, we do not understand how the discovered 70+49 new European incipient phylogenetic species of limnephilid caddisflies have been evolved in the isolated sky island habitats of high mountain ranges. This isolation induced speciation represents a challenge to the mechanistic reductionist concept of the natural selection. Our first trial to extract information from various disciplines to answer this question is presented in a brief theoretical discourse: (1) rethinking the status of natural selection towards postdarwinism; (2) teleology or teleonomy; (3) limits and potentials in understanding reality; (4) organisation of universe by integration; (5) what are and how the organising forces are powered to work in the emerging en...

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Section: Shape Divergencementioning

confidence: 98%

Revision of Drusinae subfamily (Trichoptera, Limnephilidae): divergence by paraproct and paramere: speciation in isolation by integration

Oláh¹,

Beshkov²,

Chvojka³

et al. 2017

Opusc Zool

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“…The DGRP strains are demonstrated to have overall low linkage disequilibrium (LD) (Mackay et al. ) and Wolbachia infection of them is known to have little effect on their genital morphology (Takahara and Takahashi ), which are ideal characteristics for conducting genotype‐phenotype association analysis. We performed genome‐wide association analysis to associate the mean PC scores and posterior lobe size of each DGRP strain with 1,877,926 SNPs using the following mixed linear model:

Y = μ + G + T + G \times T + Q + K + ε

…”

Section: Methodsmentioning

confidence: 99%

“…To avoid the systemic among-strain variation due to tracing bias in the process of outline acquisition, the same person performed all of the tracing of the outlines in this study. Because the experimental conditions of the control treatment were exactly the same as the ones of Takahara & Takahashi (2015), we used posterior lobe images captured by Takahara and Takahashi (2015) for 155 DGRP strains that overlapped with the strains used in the current study, and captured new images for the four DGRP strains that were not included in Takahara and Takahashi (2015).…”

Section: And Shape and Size Analysismentioning

confidence: 99%

“…; Macdonald and Goldstein ; Tanaka et al. ) and genome‐wide association analysis was recently performed using DGRP strains (Takahara and Takahashi ). Because male genital morphology in general is known to be robust against environmental and genetic perturbations, HSP90 may play a role as a capacitor and/or potentiator for the posterior lobe morphology of D. melanogaster .…”

mentioning

confidence: 99%

“…Drosophila melanogaster and its closely related species are morphologically very similar, but the shapes of the posterior lobe, a cuticular projection on the male genital arch, are distinct from each other (Ashburner et al 2005). The genetic architecture underlying the intra-and interspecific variation in posterior lobe shape and size has been intensively studied (Liu et al 1996;Macdonald and Goldstein 1999;Tanaka et al 2015) and genomewide association analysis was recently performed using DGRP strains (Takahara and Takahashi 2015). Because male genital morphology in general is known to be robust against environmental and genetic perturbations, HSP90 may play a role as a capacitor and/or potentiator for the posterior lobe morphology of D. melanogaster.…”

mentioning

confidence: 99%

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HSP90 as a global genetic modifier for male genital morphology inDrosophila melanogaster

2018

Self Cite

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The molecular chaperone protein HSP90 has been proposed to modulate genotype-phenotype relationship in a broad range of organisms. We explore the proposed genetic modifier effect of HSP90 through a genomewide analysis. Here, we show that HSP90 functions as a genetic modifier of genital morphology in Drosophila melanogaster. We identified a large number of single-nucleotide polymorphisms (SNPs) with an HSP90-dependent effect by using genome wide association analysis. We classified the SNPs into the ones under capacitance effect (smaller allelic effect under HSP90 inhibition) or the ones under potentiation effect (larger allelic effect under HSP90 inhibition). Although the majority of SNPs are under capacitance, there are a large number of SNPs under potentiation. This observation provides support for a model in which Hsp90 is not described exclusively as a "genetic capacitor," but is described more broadly as a "genetic modifier." Because the majority of the candidate genes estimated from SNPs with an HSP90-dependent effect in the current study has never been reported to interact with HSP90 directly, the global genetic modifier effect of HSP90 may be exhibited through epistatic interactions in gene regulatory networks.

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Assessing the patterns and drivers of shape complexity in the amblypygid pedipalp

McLean

Garwood

Brassey

2021

Ecology and Evolution

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Amblypygids are a group of predatory arachnids bearing a unique pair of raptorial pedipalps. The order comprises ca. 220 extant species (McArthur et al., 2018). The raptorial appendages in amblypygids are homologous to the claw-bearing limbs of scorpions and thelyphonids that are used for prey capture in those groups, and to the limb bearing the palpal bulb in male spiders, which is used as a means of transferring sperm during mating. In common with other arachnids, the amblypygid pedipalp performs multiple functions, most notably prey capture (Santer & Hebets, 2011;Weygoldt, 2000).However, recent work has also highlighted the importance of the

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Genome-Wide Association Study on Male Genital Shape and Size in Drosophila melanogaster

Cited by 27 publications

References 32 publications

Revision of Drusinae subfamily (Trichoptera, Limnephilidae): divergence by paraproct and paramere: speciation in isolation by integration

Revision of Drusinae subfamily (Trichoptera, Limnephilidae): divergence by paraproct and paramere: speciation in isolation by integration

HSP90 as a global genetic modifier for male genital morphology inDrosophila melanogaster

Assessing the patterns and drivers of shape complexity in the amblypygid pedipalp

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