Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behçet's disease

Abstract

These results suggest that a GIMAP cluster is a novel susceptibility locus for BD, which is involved in T-cell survival, and T-cell aberration can contribute to the development of BD.

Behçet's disease: A comprehensive review with a focus on epidemiology, etiology and clinical features, and management of mucocutaneous lesions

“…Besides our study, a recent six genome-wide association studies, [35][36][37][38][39][40] with the exception of the study by Fei et al, 35 have confirmed the association of BD with HLA-B51, and reported new susceptibility genes in the remaining part of the HLA class I region and several non-HLA genes for the disease. Two of them, conducted in Turkey 36 and Japan, 37 reported association between SNP of IL-10 and IL-23R/IL-12RB2 genes and BD.…”

HLA-B*51 the primary risk in Behçet disease

“…By comparison, B*52/MICA*009 was found in 25% of controls (8). Recently genome-wide association studies (GWASs) in different patient populations showed specific genes linked to BD in different ethnic groups; however, all the studies identified the HLA-B loci as the strongest association (9)(10)(11). However, in a recent study, deep sequencing of the HLA region identified an SNP, rs116799036, close to MICA that gave the strongest association and was independent of HLA-B*51 (12).…”

Update on the therapy of Behçet disease

“…These include HLA-A26, PSORS1C1 [Hughes et al 2013], HLA-Cw1602 [Hughes et al 2013], GIMAP [Lee et al 2013], UBAC2 [Sawalha et al 2011], IL10 and IL23-IL12RB2 [Remmers et al 2010;Mizuki et al 2010], CCR1/CCR3 [Hou et al 2012], MEFV and TLR4 [Kirino et al 2013]. As further understanding of the functional relevance of those genes emerge, new therapeutic…”