Behçet's disease: A comprehensive review with a focus on epidemiology, etiology and clinical features, and management of mucocutaneous lesions

Alpsoy, Erkan

doi:10.1111/1346-8138.13381

Cited by 246 publications

(312 citation statements)

References 107 publications

Supporting

Mentioning

279

Contrasting

Unclassified

Order By: Relevance

“…The association with HLA-B5 was first described by Ohno et al in 1973. Several studies confirmed the HLA-B51 association with BD and HLA-B51 is the strongest known genetic factor for BD [1]. The MHC region on chromosome 6p21 contains HLA and other essential genes in the immune response [14].…”

Section: Genetic Factorsmentioning

confidence: 91%

“…Several investigations have shown the association between HSV and BD. But, in some studies, this association could not detected [1,15,16]. Therefore, the role of HSV at the etiopathogenesis of BD is not clear.…”

Section: Infectious Agentsmentioning

confidence: 95%

“…The most probablehypothesis is that in genetically predisposed individuals some infectious agents such as Herpes simplex virus (HSV)-1, Streptococcus sangiuinis (S. sanguinis) or some autoantigens such as heat shock proteins (HSP) trigger the autoinflammatory reactions [1]. BD has aspects of both autoimmune disease and auto inflammatory disease.…”

Section: Infectious Agentsmentioning

confidence: 99%

“…Local trauma can trigger new oral ulceration. At the differential diagnosis of oral ulcers herpes simplex, erythema multiforme, fixed drug eruption, MAGIC syndrome, Reiter's syndrome, and Sweet's syndrome, anemia due to a deficiency of iron, vitamin B12 or folic acid, inflammatory bowel diseases, and systemic lupus erythematosus must consider [1,25,26].…”

Section: Oral Aphthosis (Ulceration)mentioning

confidence: 99%

See 3 more Smart Citations

Introductory Chapter: Behcet’s Disease - An Overview

Gönül¹,

Kartal²

2017

Behcet's Disease

View full text Add to dashboard Cite

Section: Genetic Factorsmentioning

confidence: 91%

Section: Infectious Agentsmentioning

confidence: 95%

Section: Infectious Agentsmentioning

confidence: 99%

Section: Oral Aphthosis (Ulceration)mentioning

confidence: 99%

See 2 more Smart Citations

Introductory Chapter: Behcet’s Disease - An Overview

Gönül¹,

Kartal²

2017

Behcet's Disease

View full text Add to dashboard Cite

“…Behcet's disease (BD) is a multi-systemic, inflammatory, and chronic disorder characterized by a triple-symptom complex of recurrent oral aphthous ulcers, genital ulcers, uveitis [1,2], and other diverse spectrum of clinical manifestations, including skin, joint, Central Nervous System (CNS), gastrointestinal, pulmonary, and cardiovascular system involvement, which are reported in addition to the major findings of this disorder. Cardiac involvement in BD is known as cardio-Behcet's disease that occurs in 7% to 31% of patients with BD, with a mortality rate of 20% [3].…”

Section: Introductionmentioning

confidence: 99%

Dilated Cardiomyopathy in Behcet′s Disease in a Young Male Patient

Khederlou

Taheri

Sadeghi

et al. 2017

ijcp

View full text Add to dashboard Cite

Behcet's disease is a multi-systemic, inflammatory, and chronic disorder characterized by recurrent oral aphthous ulcers, genital ulcers, uveitis, and other systemic organ involvement. Cardiac involvement in Behcet's disease is rare; however, it plays an important role in prognosis and increases mortality. The current researchers hereby have reported a case of Behcet′s disease with dilated cardiomyopathy. A 28-year-old male patient was presented with constitutional symptoms, oral and genital aphthous ulcers, pseudofolliculitis, tachycardia, arthritis, splenomegaly, erythrocyte sedimentation rate and C-reactive protein elevation, and left ventricular systolic dysfunction with left ventricular ejection fraction of 45%. Azathioprine and prednisolone were begun for the patient.

show abstract

Significant Decline in the Incidence of Behçet’s Disease in South Korea: A Nationwide Population‐Based Study (2004–2017)

Jun

Kim

Kazmi

et al. 2021

Arthritis Care & Research

View full text Add to dashboard Cite

Objective Long‐term population‐based data on change in the incidence of Behçet’s disease (BD) are scarce, although a possible decline has been reported. The present study was undertaken to investigate the incidence, survival, and mortality of BD patients from 2004 to 2017 in the Republic of Korea. Methods We analyzed a registry of rare intractable diseases and a claims database from the Health Insurance and Review Agency with information on BD patients between 2004 and 2017 using uniform diagnostic criteria. The study period was divided into 3 time periods: 2004–2006, 2007–2010, and 2011–2017. Results The annual incidence of BD decreased from 8.15 per 100,000 in 2004 to 1.51 in 2017, an 81.5% decrease. The annual percentage change was 6.32% for female patients and 6.15% for male patients. The decrease in BD incidence was greater for women and middle‐aged people. The 3‐year survival rate of BD patients during the 2011–2017 period was lower than that of BD patients in 2004–2006 and 2007–2010, although there was no statistical difference. The standardized mortality rates increased significantly in the 2011–2017 period compared to the first 2 periods. Conclusion BD incidence decreased from 2004 to 2017 in the Republic of Korea. This decline in incidence might be attributable to changes in environmental factors, including a reduction in the burden of infectious diseases in the past decades and improvement in oral health during childhood. The unprecedented decline in the incidence of BD in the Republic of Korea without major changes in genetic background suggests that environmental factors are very important to the development of BD.

show abstract

Behçet's disease: A comprehensive review with a focus on epidemiology, etiology and clinical features, and management of mucocutaneous lesions

Cited by 246 publications

References 107 publications

Introductory Chapter: Behcet’s Disease - An Overview

Introductory Chapter: Behcet’s Disease - An Overview

Dilated Cardiomyopathy in Behcet′s Disease in a Young Male Patient

Significant Decline in the Incidence of Behçet’s Disease in South Korea: A Nationwide Population‐Based Study (2004–2017)

Contact Info

Product

Resources

About