Genome sequence of the plant growth promoting strain Bacillus amyloliquefaciens subsp. plantarum B9601-Y2 and expression of mersacidin and other secondary metabolites

He, Ping; Hao, Kun; Blom, Jochen; Rückert, Christian; Vater, Joachim; Mao, Zichao; Wu, Yixin; Hou, Mingsheng; He, Yueqiu; Borriss, Rainer

doi:10.1016/j.jbiotec.2012.12.014

Cited by 80 publications

(60 citation statements)

References 41 publications

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“…The mersacidin gene cluster includes the structural gene mrsA , two modification genes (Additional file 2: Table S2), i.e. mrsM coding for both dehydration and cyclation and mrsD coding for a C-terminal S-[(Z)-2-aminovinyl]-3methyl-D-cysteine formation enzyme, and the gene mrsT coding for a transporter with an associated protease domain, as well as three genes, mrsEFG , coding for immunity and three genes, mrsR1, R2, K1 , coding for regulation [37–39]. …”

Section: Resultsmentioning

confidence: 99%

“…It is an inhibitor of prokaryotic protein synthesis, constituted by an open-chain enamine acid with an extended polyene system and shows good antimicrobial activity against human pathogens such as Serratia marcescens , Klebsiella pneumoniae and S. aureus [37, 169, 170]. Difficidin is known to be produced by B. amyloliquefaciens strains, which is active against the phytopathogen Erwinia amylovora causing fire blight, and contains a highly unsaturated macrocyclic polyene comprising a 22 membered carbon skeleton with a phosphate group rarely found in secondary metabolites [171].…”

Section: Resultsmentioning

confidence: 99%

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Identification and classification of known and putative antimicrobial compounds produced by a wide variety of Bacillales species

2016

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BackgroundGram-positive bacteria of the Bacillales are important producers of antimicrobial compounds that might be utilized for medical, food or agricultural applications. Thanks to the wide availability of whole genome sequence data and the development of specific genome mining tools, novel antimicrobial compounds, either ribosomally- or non-ribosomally produced, of various Bacillales species can be predicted and classified. Here, we provide a classification scheme of known and putative antimicrobial compounds in the specific context of Bacillales species.ResultsWe identify and describe known and putative bacteriocins, non-ribosomally synthesized peptides (NRPs), polyketides (PKs) and other antimicrobials from 328 whole-genome sequenced strains of 57 species of Bacillales by using web based genome-mining prediction tools. We provide a classification scheme for these bacteriocins, update the findings of NRPs and PKs and investigate their characteristics and suitability for biocontrol by describing per class their genetic organization and structure. Moreover, we highlight the potential of several known and novel antimicrobials from various species of Bacillales.ConclusionsOur extended classification of antimicrobial compounds demonstrates that Bacillales provide a rich source of novel antimicrobials that can now readily be tapped experimentally, since many new gene clusters are identified.Electronic supplementary materialThe online version of this article (doi:10.1186/s12864-016-3224-y) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Identification and classification of known and putative antimicrobial compounds produced by a wide variety of Bacillales species

2016

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“…plantarum Y2 strain. 71 An incomplete cluster, comprising the immunity genes mrsF, mrsG, and mrsE and the transcriptional regulators mrsK2 and mrsR2, was found in B. amyloliquefaciens subsp. plantarum FZB42.…”

Section: ■ Mode Of Action and Bioactivity Spectrummentioning

confidence: 99%

Class I and Class II Lanthipeptides Produced by Bacillus spp.

2015

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The increasing number of multidrug-resistant pathogens, along with the small number of new antimicrobials under development, leads to an increased need for novel alternatives. Class I and class II lanthipeptides (also known as lantibiotics) have been considered promising alternatives to classical antibiotics. In addition to their relevant medical applications, they are used as probiotics, prophylactics, preservatives, and additives in cosmetics and personal-care products. The genus Bacillus is a prolific source of bioactive compounds including ribosomally and nonribosomally synthesized antibacterial peptides. Accordingly, there is significant interest in the biotechnological potential of members of the genus Bacillus as producers of antimicrobial lanthipeptides. The present review focuses on aspects of the biosynthesis, gene cluster organization, structure, antibacterial spectrum, and bioengineering approaches of lanthipeptides produced by Bacillus strains. Their efficacy and potency against some clinically relevant strains, including MRSA and VRE, are also discussed. Although no lanthipeptides are currently in clinical use, the information herein highlights the potential of these compounds.

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“…enzymes (chitinase, peroxidases and proteases), casein, elastin, gelatin, starch, nitrites, esculin and arbutin, phosphatases, adenine, cellulose, guanine, hypoxanthine, pectin, testosterone, tyrosine, and many types of antibiotics (eg. bacillomycins, fengycin, difficidin) and other substances [39][40][41][42]. Production of antibiotic inhibiting growth of fungal pathogens [13].…”

Section: Rhizobox Experimentsmentioning

confidence: 99%

“…The bacteria also reduce the influence of abiotic stress conditions at the plant, such as drought, salinity or lack of nutrients in the plant [39][40][41]47,48]. He et al [41] dealt in their study with influence of B. amyloliquefaciens inoculation on the growth of rice plants under stress conditions caused by salinity for 30 days. This study was based on the assumption that the use of microorganisms provides an alternative technology to improve the ability of stress tolerance in plants.…”

Section: Rhizobox Experimentsmentioning

confidence: 99%

Use of Active Microrganisms in Crop Production - A Review

Holečková¹,

Kulhánek²,

Balík³

2017

J Food Process Technol

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Phosphorus, other elements and natural resources are scarce, and so it is necessary to find alternative strategy to increase availability of nutrients for plants. One possible way could be application of so-called bioeffectors (BE) which should improve the mobilisation of nutrients (especially phosphorus) from less available forms in soil, improve plant growth and contribute to mycorrhiza development. BEs are commercially supplied products which contain active substances (live microorganisms and active natural compounds). BEs can be used in organic agriculture, because their application represents no risk for the environment. Several studies and experiments are focused on impact of bioeffectors' application and their active compounds on plants. Experiments were performed under different conditions (field, pot, greenhouse), on various testing plants and on various bioeffectors. These BEs have been used as a fertilizer, fungicide or molluscicide and they were applied either to soil, seed or leaf. Application should increase growth of root system and above-ground part of plants and also nutrient uptake. These products are developed for a wide variety of crops (e.g. maize, wheat, tomatoes, rape, spinach, grass, ornamentals). This review summarizes the most recent knowledge in this scientific field. Use of Active Microrganisms in Crop Production-A ReviewZlata Holečková*, Martin Kulhánek and Jiří Balík Department of Agro-Environmental Chemistry and Plant Nutrition, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences, Prague, Czech RepublicMycorrhiza is highly effective in absorbing nutrients from the soil, especially for nitrogen and phosphorus. Nitrogen and phosphorus are often limited in supply and fungal hyphae are able to absorb these nutrients more efficiently and from greater area of soil than the roots, which leads to increased plant growth. This causes mutually beneficial linkage between plants and fungi, the sugars (organic carbon) formed during photosynthesis are transported to the roots and the fungi are taken and the nutrients are absorbed by fungal hyphae from the soil and are transported into plants [10,11]. Arbuscular mycorrhizal fungi colonise most agricultural species (exceptions include Brassica spp., and Lupinus spp.) and play an important role in the phosphorus nutrition of many farming systems worldwide, especially on soils with low available phosphorus [3]. Literature ReviewExamples of plant strategies for phosphorus obtaining: One alternative strategy in plant production can be use of unmycorrhizal organism's P mobilizing nutrients, which should help to increased nutrient availability for plants. These substances are so-called bioeffectors.

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Genome sequence of the plant growth promoting strain Bacillus amyloliquefaciens subsp. plantarum B9601-Y2 and expression of mersacidin and other secondary metabolites

Cited by 80 publications

References 41 publications

Identification and classification of known and putative antimicrobial compounds produced by a wide variety of Bacillales species

Identification and classification of known and putative antimicrobial compounds produced by a wide variety of Bacillales species

Class I and Class II Lanthipeptides Produced by Bacillus spp.

Use of Active Microrganisms in Crop Production - A Review

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