Genome Sequence of the “Indian Bison Type” Biotype of Mycobacterium avium subsp. paratuberculosis Strain S5

Abstract

We report the 4.79-Mb genome sequence of the “Indian Bison Type” biotype of Mycobacterium avium subsp. paratuberculosis strain S5, isolated from a terminally sick Jamunapari goat at the CIRG (Central Institute for Research on Goats) farm in India. This draft genome will help in studying novelties of this biotype, which is widely distributed in animals and human beings in India.

Mycobacterium avium ssp . paratuberculosis detection in animals, food, water and other sources or vehicles of human exposure: A scoping review of the existing evidence

“…through irrigation) and seafood. Further research is required to examine how hardy M. paratuberculosis is in its spore-like state and how long it survives in manure storage and composting to better understand the risk of contaminating other potential environmental sources of M. paratuberculosis for humans (Lamont et al, 2012 (Singh et al, 2013;Ahlstrom et al, 2015). The multitude of molecular methods used to date has been a barrier to meaningful synthesis of molecular epidemiological results (Ahlstrom, et al, 2015;Muellner, et al, 2015), therefore as data from whole genome sequencing become more widely used in epidemiological investigations, researchers should seek consensus on target markers to aid in the comparability of results across studies.…”

“…Citations retrieved from all databases were imported into reference management software RefWorks (Copyright 2015, ProQuest LLC) and de-duplicated. Search verification included screening reference lists of seven review articles (Anon, 2010;Grant, 2010;Kaevska and Hruska, 2010;Mor-Mur and Yuste, 2010;Singh et al, 2010a;Over et al, 2011;Carta et al, 2013) and five systematic reviews published on M. paratuberculosis (Feller et al, 2007;Abubakar et al, 2008;Eltholth et al, 2009;Okura et al, 2012;Fernandez-Silva et al, 2014).…”

Evalution of “indirect fluorescent antibody test‟ as potential screening test for Mycobacterium avium subspecies paratuberculosis using milk of lactating domestic livestock

“…Mycobacterium avium subspecies paratuberculosis (MAP), cause the incurable Paratuberculosis or Johne"s disease, it is an infectious disease of the intestinal tract, primarily infects domestic livestock (Singh et al, 2011;Singh et al, 2014a). It is globally known that milk and milk products made from pasteurized milk of endemically infected domestic livestock contain live MAP bacilli.…”

Dose Standardization Studies of 'Indigenous Vaccine' for the Control of Mycobacterium Avium Subspecies Paratuberculosis in Naturally Infected Goats

“…Treatment of JD is both expensive and impractical (Harris and Barletta, 2001), therefore, vaccination is the only promising way in controlling JD. Development of indigenous vaccine for commercial exploitation is underway and in earlier studies on 'indigenous vaccine' (Singh et al, 2007a;Singh et al, 2013c;Singh et al, 2013d) though showed good response when used in herds/flocks of goats, sheep, cattle and buffaloes, however, the dose rate of 2.5 and 5.0 mg per animal in small and large ruminants, respectively for lifetime were accrued from the International literature (Perez et al, 1995). During trials of vaccine in cattle with poor nutrition status, cows exhibited increase in shedding of MAP at around 8 months post vaccination after showing decrease in shedding up to 8 months after vaccination (personal observations).…”