Genome-edited crops: how to move them from laboratory to market

Kunling, Chen; Gao, Caixia

doi:10.15302/j-fase-2020332

Cited by 16 publications

(10 citation statements)

References 36 publications

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“…Since genome editing is not a single technology but rather a molecular toolbox, a comprehensive, one-size-fits-all regulatory approach may be unsuitable. Instead, a tiered regulatory system should be used to accommodate both existing and future technologies (Chen and Gao, 2020;Lassoued et al, 2020;Macnaghten and Habets, 2020). More effort is needed to ensure regulatory transparency and open dialog.…”

Section: Plant Microbiome Engineeringmentioning

confidence: 99%

Genome engineering for crop improvement and future agriculture

Gao

2021

Cell

Self Cite

532

340

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Section: Plant Microbiome Engineeringmentioning

confidence: 99%

Genome engineering for crop improvement and future agriculture

Gao

2021

Cell

Self Cite

532

340

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“…SDNs provide unprecedented control over precise genome modifications, with greater cost-effectiveness and efficiency than plant breeding and genetic engineering. Plant varieties created using SDNs do not contain exogenous genetic material and could have resulted from natural processes [ 119 , 120 , 121 ]. SDN applications may result in three types of plants: Plants with new genetic element; Plants with point mutations in existing DNA but no new DNA; Plants with no genome modification.…”

Section: Classification Of Genome Editing Modificationsmentioning

confidence: 99%

An Outlook on Global Regulatory Landscape for Genome-Edited Crops

Ahmad

Munawar

Khan

et al. 2021

IJMS

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The revolutionary technology of CRISPR/Cas systems and their extraordinary potential to address fundamental questions in every field of biological sciences has led to their developers being awarded the 2020 Nobel Prize for Chemistry. In agriculture, CRISPR/Cas systems have accelerated the development of new crop varieties with improved traits—without the need for transgenes. However, the future of this technology depends on a clear and truly global regulatory framework being developed for these crops. Some CRISPR-edited crops are already on the market, and yet countries and regions are still divided over their legal status. CRISPR editing does not require transgenes, making CRISPR crops more socially acceptable than genetically modified crops, but there is vigorous debate over how to regulate these crops and what precautionary measures are required before they appear on the market. This article reviews intended outcomes and risks arising from the site-directed nuclease CRISPR systems used to improve agricultural crop plant genomes. It examines how various CRISPR system components, and potential concerns associated with CRISPR/Cas, may trigger regulatory oversight of CRISPR-edited crops. The article highlights differences and similarities between GMOs and CRISPR-edited crops, and discusses social and ethical concerns. It outlines the regulatory framework for GMO crops, which many countries also apply to CRISPR-edited crops, and the global regulatory landscape for CRISPR-edited crops. The article concludes with future prospects for CRISPR-edited crops and their products.

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“…Currently, the commercial development of Zhang et al, 2017;Zhao et al, 2017;Gao et al, 2018;Zhang et al, 2018b Zhang et al, 2017;Zhao et al, 2017;Gao et al, 2018;Zhang et al, 2018b; genetically modified organisms (GMOs) is considered a threat to human health and the environment and is thus under stringent governmental regulations (Prado et al, 2014). Transgene-free edited crops created via CRISPR/Cas9 receive the regulatory waivers in many countries (Chen and Gao, 2020). Transgene-free edited crops can be generated through conventional and transient expression methods.…”

Section: Applications Of the Crispr/cas9 System In Transgene-free Crop Breedingmentioning

confidence: 99%

MicroRNA Techniques: Valuable Tools for Agronomic Trait Analyses and Breeding in Rice

et al. 2021

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MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression at the post-transcriptional level. Extensive studies have revealed that miRNAs have critical functions in plant growth, development, and stress responses and may provide valuable genetic resources for plant breeding research. We herein reviewed the development, mechanisms, and characteristics of miRNA techniques while highlighting widely used approaches, namely, the short tandem target mimic (STTM) approach. We described STTM-based advances in plant science, especially in the model crop rice, and introduced the CRISPR-based transgene-free crop breeding. Finally, we discussed the challenges and unique opportunities related to combining STTM and CRISPR technology for crop improvement and agriculture.

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Genome-edited crops: how to move them from laboratory to market

Cited by 16 publications

References 36 publications

Genome engineering for crop improvement and future agriculture

Genome engineering for crop improvement and future agriculture

An Outlook on Global Regulatory Landscape for Genome-Edited Crops

MicroRNA Techniques: Valuable Tools for Agronomic Trait Analyses and Breeding in Rice

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