Genitourinary changes in hamsters infected and reinfected with Trypanosoma cruzi

Cabrine-Santos, Marlene; Santos, Vitorino Modesto dos; Lima, Marcus Aurelho de; Abreu, Marta Elena Araújo de; Lages‐Silva, Eliane; Ramı́rez, Luı́s Eduardo

doi:10.1590/s0074-02762003000400018

Cited by 4 publications

(2 citation statements)

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“…However, changes due to T. cruzi infection in other sites, such as gonads and kidneys (Cabrine-Santos et al 2003), central nervous system and endocrine glands (Saldanha et al 2001;Santos et al 2002), have not been objects of research to the same extent. Especially, in spite of accumulating evidence that the pancreas may be affected by Trypanosoma cruzi infection, this has not provoked similar interest.…”

Section: Introductionmentioning

confidence: 99%

Functional and histopathological study of the pancreas in hamsters (Mesocricetus auratus) infected and reinfected with Trypanosoma cruzi

et al. 2004

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Histopathological and functional changes in the pancreas were studied in 94 hamsters infected and reinfected with Trypanosoma cruzi VIC strain and in 73 non-infected normal controls. Infection in each animal was verified by microhematocrit, hemoculture, specific peroxidase anti-peroxidase, polymerase chain reaction and seroagglutination. Blood glucose and insulin were determined. The number of islets per section and the number of islet cells marked with antibodies were counted. Insulitis, neuritis, fibrosis, atrophy and inflammatory infiltrates were evaluated. Experimental chagasic infection caused pancreatitis similar to human Chagas' disease, involving acini, islets and nerves, with atrophy and fibrosis, although without correlation to the number of reinfections. Erratic blood glucose levels and a tendency to hypoinsulinemia were observed in infected animals. During the acute phase, the number of somatostatin and pancreatic polipeptide producer islet cells was lower in infected hamsters, which was eventually related to changes in blood sugar levels and hypoinsulinemia. Our findings favor the hypothesis of the existence of an endocrine form of chronic chagasic infection.

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Section: Introductionmentioning

confidence: 99%

Functional and histopathological study of the pancreas in hamsters (Mesocricetus auratus) infected and reinfected with Trypanosoma cruzi

et al. 2004

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“…The alteration of sexual potency, pleasure, and fertility have been assessed previously, demonstrating that Chagas disease was responsible for an alteration of sperm quality and quantity [20, 21].…”

Section: Discussionmentioning

confidence: 99%

Lower urinary tract dysfunction in chronic Chagas disease: clinical and urodynamic presentation

Bey¹,

Condori²,

Gaget³

et al. 2018

World J Urol

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Purpose To describe and give an estimation of the prevalence of urinary disorders in chronic Chagas disease, since most clinical research has been centered on the description of the cardiac and digestive forms. Methods To explore this topic, a cross-sectional study was conducted in 137 Bolivian adults of both sexes suffering from symptomatic chronic Chagas disease. All patients presenting confirmed chagasic cardiomyopathy, megacolon or both underwent a urologic symptom questionnaire, uroflowmetry, urinary tract ultrasonography and a creatinine assay. When urinary abnormality was detected, a complete urodynamic study was proposed including cystometry, pressure-flow studies and urethral pressure profile. Results Out of all study patients, 35 (26%) had a Chagas cardiomyopathy, 81 (59%) a megacolon, and 21 (15%) a megacolon associated with cardiomyopathy. In all, 63% presented urinary disorders defined by IPSS > 7 and/or ICIQ SF > 1. Among them, 62% were incontinent, mainly by bladder overactivity, and 45% presented grade 2 or 3 renal insufficiency. Of 49 patients, the urodynamic study identified 34 patients with detrusor overactivity (69%), mostly in those with Chagas megacolon. Median bladder functional capacity, urethral closure pressure and bladder compliance had normal values. Moreover, 36% of these patients presented moderate hypocontractility, without significant post-void residual. Conclusions This study evidenced lower urinary tract dysfunction in a majority of chronic chagasic patients; those presenting megacolon were more likely to suffer from urinary incontinence. These results strongly suggest including routine urological clinical investigation in chronic Chagas patients, as urinary incontinence due to overactive bladder is frequently observed in this population.

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Trypanosoma cruzi and hematospermia

et al. 2019

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Genitourinary changes in hamsters infected and reinfected with Trypanosoma cruzi

Cited by 4 publications

References 14 publications

Functional and histopathological study of the pancreas in hamsters (Mesocricetus auratus) infected and reinfected with Trypanosoma cruzi

Functional and histopathological study of the pancreas in hamsters (Mesocricetus auratus) infected and reinfected with Trypanosoma cruzi

Lower urinary tract dysfunction in chronic Chagas disease: clinical and urodynamic presentation

Trypanosoma cruzi and hematospermia

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