Genital malformations in newborns of female nickel-refinery workers

Vaktskjold, Arild; Talykova, Ljudmila; Chashchin, Valery; Nieboer, Evert; Thomassen, Yngvar; Odland, Jon Øyvind

doi:10.5271/sjweh.975

Cited by 40 publications

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References 42 publications

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“…The studies focused especially on toxic metals and adverse pregnancy outcomes (5)(6)(7)(8) and, more specifically, on the effect of nickel exposure on women working in the nickel industry (9)(10)(11)(12)(13)(14)(15)(16)(17). It became apparent that in order to obtain sufficient sample sizes for statistical comparisons, larger cohorts needed to be defined.…”

Section: Introductionmentioning

confidence: 99%

“…By 003, over 5,000 births were registered that went back as far as 1973. Several articles have been published using this database together with personal exposure assessments (9)(10)(11)(12)(13)(14)(15)(16)(17) to examine the effects of occupational nickel exposure on pregnancy outcomes. The implementation and use of this research registry demonstrated the need for a medical birth registry for all the towns and cities of MO, and its planning was begun in 005.…”

Section: Introductionmentioning

confidence: 99%

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Implementation, Quality Control and Selected Pregnancy Outcomes of the Murmansk County Birth Registry in Russia

Anda

Nieboer

Voitov

et al. 2008

International Journal of Circumpolar Health

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Objectives. To describe the essential features of the newly established Murmansk County Birth Registry (MCBR); make some preliminary comparisons of selected variables related to pregnancy and delivery in northern counties of the Nordic countries and in cities and towns of Murmansk County [Murmanskaja Oblast (MO)] and explore some research possibilities. Study design. A registry-based cohort study. Methods. The MCBR was established in 005 and registration began on 1 January 006. A registry form draws upon both hospital files and information from the mother. There are 54 major fields consisting primarily of tick-off boxes and International Classification of Diseases (ICD-10) codes. A quality control exercise was conducted in both 2006 and 2007. Results. During 006,8,468 births were registered in the MO (coverage = 98.9%). The proportion of errors was below 1% in both years. Limiting the descriptive statistics to 006, compared to counties of the Nordic counties in the Barents Region, the delivering women in the MO were younger and had fewer and lighter (mean of 00 g) babies. The gestational age was somewhat shorter in the MO than in the Nordic counties and fewer babies had a birthweight above 4,500 g. The perinatal mortality corresponding to a gestational age (GA) of either or 8 completed weeks was higher (p<0.0) in the MO than the Nordic counties in this study. In the MO, the birth rate does not balance the reported increase in death rate. Conclusions. Our study concludes that a medical birth registry of satisfactory quality has been established for the world's largest arctic population. (Int J Circumpolar Health 2008; 67(4):318-334)

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Implementation, Quality Control and Selected Pregnancy Outcomes of the Murmansk County Birth Registry in Russia

Anda

Nieboer

Voitov

et al. 2008

International Journal of Circumpolar Health

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“…Of particular concern are long-term, subtle effects that may influence reproductive health and pregnancy outcomes, thus reducing defence against diseases and affecting children's mental development, or increasing the risk of cancer. 22,24,25 This study was designed to evaluate the degree of environmental contamination and possible exposure of pregnant women to toxic substances in the selected areas of São Paulo State, Brazil, so as to inform reproductive, paediatric, public and environmental health practices.…”

Section: Introductionmentioning

confidence: 99%

Toxic and essential elements in blood from delivering women in selected areas of São Paulo State, Brazil

et al. 2011

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This study was designed to evaluate the degree of environmental contamination and possible exposure of pregnant women to toxic elements in seven selected areas of São Paulo State, Brazil. The overall median concentration of Mo in maternal blood was 0.53 mg L À1 , highly significant differences found between sites (p < 0.0001). Cd was found to be low overall À 0.09 mg L À1 (0.01-0.58 mg L À1 ) -with mothers from the Coastal and Rural 1 sites having the highest levels (p < 0.016). Median Hg concentration was 0.60 mg L À1 (0.06 mg L À1 -4.35 mg L À1 ); median Pb level was 16.2 mg L À1 (3.5-57.7 mg L À1 ) and no differences between sites were observed for both metals. Median Mn level was 16.7 mg L À1 (7.0-39.7 mg L À1 ), being highest in Urban 2 site (p<0.016). Concentrations of maternal Co were found to range between 0.06 mg L À1 and 1.1 mg L À1 (median 0.25 mg L À1 ) and As level was 0.60 mg L À1 (0.10-3.8 mg L À1 ) overall, with no statistical significance between sites for Co and As. Median Se concentrations were found to be 64 mg L À1 (36-233 mg L À1 ), with the highest median levels found in Urban 3 site; site differences were statistically significant (p < 0.0001). Correlation for each element (between paired maternal and cord blood) was measured only in Rural site 1; significant correlation was shown for Hg, Pb, Mn and Co (p<0.05). These findings may be interpreted as indicating low environmental contamination in São Paulo State, Brazil. These findings could also indicate that pregnant women have little or no contact with pollutants, possibly due to awareness campaigns carried out by public health practitioners.

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“…The studies have revealed high levels of air pollution (2,3); elevated urinary-nickel concentrations (4,5); no measurable impairment of lung function due to sulphur dioxide (6); high abortion rates (7); possibly elevated incidences of congenital malformations among newborns (8); no association of genital malformations at birth after nickel exposure (9); a relatively low mean birth weight (4); a low proportion of the delivering women at elevated risk of adverse pregnancy outcomes due to high maternal age (7); different concentrations of essential and toxic elements in placentas when compared with communities in Northern Norway (10); a lower prevalence of atopic dermatitis (11,12) and allergic asthma (12); occupational exposures to potential harmful compounds (13,14); and a high proportion of female industrial workers (15). Some of the studies were based on the data in the Kola Birth Registry (KBR) (7,9,15). The KBR contains extensive data about all live births as well as stillbirths of at least 28 weeks of gestation.…”

Section: Introductionmentioning

confidence: 99%

Pregnancy health and outcome in two cities in the Kola Peninsula, Northwestern Russia

Talykova

Vaktskjold

Serebrjakova³

et al. 2007

International Journal of Circumpolar Health

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Objectives. The aims of the study were to compare the prevalence of selected maternal and lifestyle factors as well as the reproductive outcome of working women in two cities in Northwestern Russia (Mončegorsk and Apatity), and to assess the quality of pregnancy-outcome data obtained in an interview with registered information. Study design. A retrospective questionnaire study in an interview format. Women (n=1696) from selected workplaces in Apatity and Mončegorsk participated (85% of those available). Information was collected about past pregnancies, including information about the pregnancy outcome, newborn, occupation, health and life-style. Results. The investigated groups had experienced 7,254 pregnancies in total, corresponding to 4.3 pregnancies on average per woman. In both groups, about one-half of the reported pregnancies were terminated, and three-quarters of the women had undergone an induced abortion. Spontaneous abortions had been experienced by 23% of the women in the Apatity group, which was higher than in the Mončegorsk group (16%). Previous spontaneous abortions appear more likely to be disclosed than induced abortions. The smoking prevalence was 37% in the Mončegorsk group and 24% in the Apatity group. Thirteen percent of all participants had been diagnosed with a pelvic inflammatory disease. Conclusions. Induced abortions were common in Northwestern Russia regardless of city of residency, and the majority of the abortions appear to have occurred after the women had their attainable or desired number of children. The proportion of pregnancies resulting in a spontaneous abortion was higher in the investigated group in Apatity than in Mončegorsk, which should be investigated further. This study also confirmed that smoking has become more widespread among women in the Kola Peninsula, as elsewhere in

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Genital malformations in newborns of female nickel-refinery workers

Cited by 40 publications

References 42 publications

Implementation, Quality Control and Selected Pregnancy Outcomes of the Murmansk County Birth Registry in Russia

Implementation, Quality Control and Selected Pregnancy Outcomes of the Murmansk County Birth Registry in Russia

Toxic and essential elements in blood from delivering women in selected areas of São Paulo State, Brazil

Pregnancy health and outcome in two cities in the Kola Peninsula, Northwestern Russia

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