Toxic and essential elements in blood from delivering women in selected areas of São Paulo State, Brazil

Rudge, Cibele Vieira Cunha; Calderon, Iracema de Mattos Paranhos; Rudge, Marilza Vieira Cunha; Volpato, Gustavo Tadeu; Silva, Joao L.P.; Duarte, Geraldo; Neto, Corintio Mariani; Sass, Nelson; Mattar, Rosiane; Röllin, Halina B.; Thomassen, Yngvar; Odland, Jon Øyvind

doi:10.1039/c0em00570c

Cited by 13 publications

(14 citation statements)

References 38 publications

(43 reference statements)

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“…As DRCs are pollutants of urban/industrial origin, it is worth mentioning that SP houses a human population of approximately 40 million people (Rudge et al, 2011). In addition, the metropolitan area of São Paulo city constitutes the most industrialized center of Latin America (Saldiva et al, 1994).…”

Section: Franciscana Dolphinsmentioning

confidence: 99%

High accumulation of PCDD, PCDF, and PCB congeners in marine mammals from Brazil: A serious PCB problem

Dorneles

Sanz

Eppe

et al. 2013

Science of The Total Environment

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• Dioxin-like PCBs accounted for over 83% of the total TEQ for all cetaceans • Negative correlations were found between length and TEQ values in franciscanas.• PCB concentrations found are among the highest ever reported for cetaceans. a b s t r a c t a r t i c l e i n f o Blubber samples from three delphinid species (false killer whale, Guiana and rough-toothed dolphin), as well as liver samples from franciscana dolphins were analyzed for dioxins and related compounds (DRCs). Samples were collected from 35 cetaceans stranded or incidentally captured in a highly industrialized and urbanized area (Southeast and Southern Brazilian regions). Dioxin-like PCBs accounted for over 83% of the total TEQ for all cetaceans. Non-ortho coplanar PCBs, for franciscanas (82%), and mono-ortho PCBs (up to 80%), for delphinids, constituted the groups of highest contribution to total TEQ. Regarding franciscana dolphins, significant negative correlations were found between total length (TL) and three variables, ΣTEQ-DRCs, ΣTEQ-PCDF and ΣTEQ non-ortho PCB. An increasing efficiency of the detoxifying activity with the growth of the animal may be a plausible explanation for these findings. This hypothesis is reinforced by the significant negative correlation found between TL and PCB126/PCB169 concentration ratio. DRC concentrations (ng/g lipids) varied from 36 to 3006, for franciscana dolphins, as well as from 356 to 30,776, for delphinids. The sum of dioxin-like and indicator PCBs varied from 34,662 to 279,407 ng/g lipids, for Guiana dolphins from Rio de Janeiro state, which are among the highest PCB concentrations ever reported for cetaceans. The high concentrations found in our study raise concern not only on the conservation of Brazilian coastal cetaceans, but also on the possibility of human health problem due to consumption of fish from Brazilian estuaries.

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Section: Franciscana Dolphinsmentioning

confidence: 99%

High accumulation of PCDD, PCDF, and PCB congeners in marine mammals from Brazil: A serious PCB problem

Dorneles

Sanz

Eppe

et al. 2013

Science of The Total Environment

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“…All samples were stored at -20ºC and shipped in a frozen state to University of Tromso, Norway, for analytical laboratories. The metal and POPs data from delivering women were analyzed by Rudge et al 20 and these results associated with unanalyzed data from newborns were assigned to be used in this study to determine the contamination index. To calculate the total contamination indexes of mothers and newborns, the metal and POPs concentrations were used according to the following formulas: 1) Maternal contamination index = (Σ maternal metal concentration x number of metals exposed) + (Σ maternal POPs concentration x number of POPs exposed).…”

Section: Methodsmentioning

confidence: 99%

“…These findings could indicate that pregnant women have little or no contact with pollutants, possibly due to awareness campaigns carried out by public health practitioners in Brazil. Although, it was found different metals concentrations in pregnant women from sites of São Paulo State, the highest levels in delivering was detected in pregnant women from rural areas 20 . Higher levels of pesticides in blood of delivering women mostly in rural areas.…”

Section: Introductionmentioning

confidence: 99%

“…Putting together both studies 20,21 it is possible to conclude that maternal contamination as well as the placental transfer to fetus is upon dependent of different concentration of these compounds on the two sides of the placental villus and from the placental and fetus mechanisms that actively or passively permits, facilitates and adjusts the amount and rate of transfer of a wide range of substances to the fetus 21,22 . The developmental stage during which the exposure occurs has a major influence on the consequences of this exposure.…”

Section: Introductionmentioning

confidence: 99%

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Contamination index. A novel parameter for metal and pesticide analyses in maternal blood and umbilical cord

et al. 2016

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PURPOSE:To evaluate the contamination index of metals and pesticides in pregnant women, and to relate this to perinatal outcomes. METHODS:Descriptive, retrospective, exploratory study, developed from existing secondary data analyses at Level III maternity center. A total of 40 mothers with their newborns (NB), living in a rural area in Botucatu-Brazil and surrounding region. Blood samples from mothers and newborn were collected to determine the total contamination index for metals and pesticides. The concentrations of each metal and each pesticide were determined in blood samples of mothers and their newborns by Rudge's results. After obtaining these concentrations, the total contamination index in mother and NB was calculated, along with its correlation with clinical parameters of NB. RESULTS:There was no correlation (p> 0.05) between maternal contamination index with NB clinical parameters, and NB contamination index versus NB clinical parameters. CONCLUSION:The maternal contamination index of metals and pesticides was not related to perinatal outcomes, but it could be used as baseline parameter in future toxicological studies, regarding to long-term toxic characteristics as persistent organic pollutants, its long half-lives, bioacumulative, and expected to impose serious health effects on humans.

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“…The Arctic Monitoring and Assessment Programme (AMAP) started in 1991 and currently all Arctic countries are members, namely: Canada, Denmark, Finland, Iceland, Norway, Russia, Sweden and USA [9–12]. Countries located in tropical and southern areas have joined more recently, including South Africa [8,13], Brazil [6,14], Vietnam [15] and Australia [16,17]. The extent of human exposure, as measured by biological contaminant concentrations, has not been adequately investigated in South America.…”

Section: Introductionmentioning

confidence: 99%

The Argentinian mother-and-child contaminant study: a cross-sectional study among delivering women in the cities of Ushuaia and Salta

Økland

Odland

Matiocevich³

et al. 2017

International Journal of Circumpolar Health

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Several ongoing international multidisciplinary projects have examined linkages between environmental chemicals and health. In contrast to Arctic regions, information for the Southern Hemisphere is scarce. Because of the inherent practice of pesticide utilisation and mismanagement, food security is potentially threatened. The most vulnerable period in human life occurs during pregnancy and early childhood, thus a focus on the body burdens of PTS in pregnant or delivering women is warranted. The current study was designed to investigate health risks related to exposure to PTS and food security in two regions of Argentina (Ushuaia and Salta). Our aims were to quantify concentrations of organic and inorganic toxins in serum or whole blood of delivering women and to collect pertinent dietary and medical information. The overall study design, the basic demographic features and essential clinical chemistry findings are described in the current paper. The socioeconomic differences between the two study areas were evident. On average, the women in Ushuaia were 4 years older than those in Salta (28.8 vs. 24.7 years). Respectively, the proportion of current smokers was 4.5 vs. 9.6%; and Salta had a higher birth rate, with 15.6% being para four or more. Saltanean women reported longer breastfeeding periods. Caesarean sections were more frequent in Ushuaia, with 43% of Caesarean deliveries compared with only 6% in Salta. Employment was high in both communities. Recognised environmental pollution sources in the vicinity of participant dwellings were widespread in Salta (56.1%) compared to Ushuaia (9%). The use of pesticides for insect control in homes was most common in Salta (80%). There is an urgent need for a comprehensive assessment of exposures in areas of the Southern Hemisphere. Our data set and the planned publications of observed concentrations of inorganic and organic environmental contaminants in both mothers and their newborns will contribute to this objective.

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Toxic and essential elements in blood from delivering women in selected areas of São Paulo State, Brazil

Cited by 13 publications

References 38 publications

High accumulation of PCDD, PCDF, and PCB congeners in marine mammals from Brazil: A serious PCB problem

High accumulation of PCDD, PCDF, and PCB congeners in marine mammals from Brazil: A serious PCB problem

Contamination index. A novel parameter for metal and pesticide analyses in maternal blood and umbilical cord

The Argentinian mother-and-child contaminant study: a cross-sectional study among delivering women in the cities of Ushuaia and Salta

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