Genistein modulates gene activity in psoriatic patients

Smolińska, Elwira; Węgrzyn, Grzegorz; Gabig-Cimińska, Magdalena

doi:10.18388/abp.2018_2772

Cited by 9 publications

(12 citation statements)

References 23 publications

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“…This outcome resulted in the inability to conduct any correlation analysis of inflammatory biomarkers with the clinical parameters of patients participating in this trial. Of course, clinical efficacy was rather poor in our test, which may be related to the fact that high doses of the agent do not result in better effects than low doses due to the limited absorption of isoflavone preparations 16 . In addition, frequent and modest intakes of genistein over the day rather than as a single high dose per day could be more efficient 34 .…”

Section: Discussionmentioning

confidence: 81%

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Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations

Bocheńska

Moskot

Smolińska-Fijołek

et al. 2021

Sci Rep

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Genistein is applied worldwide as an alternative medicament for psoriasis (Ps) because of its anti-inflammatory activity and perceived beneficial impact on the skin. Hereby, we report our in vivo and in vitro investigations to supplement scientific research in this area. The reduction of clinical and biochemical scores in mild to moderate Ps patients taking genistein, its safety, good tolerability with no serious adverse events or discontinuations of treatment, no dose-limiting toxicities, negligible changes in pharmacodynamic parameters and remarkable serum interleukin level alterations were documented in this study. A certain regression of the Ps phenotype was visible, based on photo-documented Ps lesion evaluation. Through in vitro experiments, we found that genistein reduced IL-17A and TNF-α induced MAPK, NF-κB, and PI3K activation in normal human epidermal keratinocytes. Moreover, at the mRNA level of genes associated with the early inflammatory response characteristic for Ps (CAMP, CCL20, DEFB4A, PIK3CA, S100A7, and S100A9) and key cellular signalling (MTORC1 and TFEB), we showed that this isoflavone attenuated the increased response of IL-17A- and TNF-α-related pathways. This allows us to conclude that genistein is a good candidate for Ps treatment, being attractive for co-pharmacotherapy with other drugs.

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Section: Discussionmentioning

confidence: 81%

“…3 in Ref. 29 ) 16 . Notably, a number of factors can influence the absorption of bioactive compounds, such as isoflavones.…”

Section: Discussionmentioning

confidence: 97%

Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations

Bocheńska

Moskot

Smolińska-Fijołek

et al. 2021

Sci Rep

Self Cite

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“…(5,7-dihydroxy-3-(4-hydroxyphenyl) chromen-4-one), natural isoflavone, impaired the activity of certain genes which are overexpressed in psoriasis. It stimulated the expression of other genes that are repressed in dermatosis in both skin specimens and peripheral blood cells of psoriatic patients 4 .…”

Section: Genisteinmentioning

confidence: 99%

“…Various plants from traditional Ayurveda, Siddha, Uighur, Thai, Korean, Chinese medicine are used for the management of various skin ailments, psoriasis, vitiligo, dermatitis, and leucoderma. A large population uses complementary medicines for two reasons, namely, the limitations of synthetic drugs and the ability of the natural compounds to act on multiple targets 4 . The plants can pave the way for new therapeutic approaches to psoriasis treatment since they have significant preventive activity against psoriasis 5 .…”

Section: Introductionmentioning

confidence: 99%

Untitled

2021

IJPSR

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Psoriasis is a skin disorder marked with inflammation. The development and progression of the disease are associated with a chronic inflammatory response, which is attributed to the dysregulated innate immune system. The dendritic cells and T cells secrete various cytokines leading to disturbances in the keratinocyte proliferation and differentiation. Several medications are available for the mitigation of psoriasis. The currently used antipsoriatic medications are expensive; carry the threat of serious side-effects and frequent remission attacks of the disease. Exploring safer and effective antipsoriatic drugs remains still a major concern. Natural products represent important treatment options for psoriasis. This review article discusses studies related to the topical formulations of anti-psoriatic plants and plant products. The pathogenesis and clinical symptoms of psoriasis include multiple immunological mechanisms and pro-inflammatory cytokines. The review aims to summarize the research done in this area and to explain the mechanism of action of herbal medicines. The review article is aimed at opening new medical approaches for treating psoriasis. All the findings suggested that various herbal constituents are responsible for anti-psoriatic activity. Herbal medicines can be used as promising anti-psoriatic agents. The antipsoriatic effects of herbal medicines are through modulation of the signaling pathways of the cells. The phytoconstituents inhibit keratinocytes proliferation and differentiation by targeting different molecular targets. The results suggested the use of plants as a safe, effective, and inexpensive option for treating psoriasis.

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“…It is thus supposed that genistein may attenuate ROS-mediated NF-κB activation and NF-κB-dependent inflammatory cytokine production in psoriatic lesional keratinocytes. Oral administration of genistein in psoriasis patients for 8 weeks impaired the transcription of genes overexpressed in psoriasis, CXCL10 , IL-6 , STAT3 , NFKB1 , CCL4 while stimulated the transcription of gene repressed in psoriasis, IL-1RN in peripheral blood cells or lesional skin [ 75 ].…”

Section: The Nutrients or Food Related To Psoriasismentioning

confidence: 99%

Nutrition and Psoriasis

Kanda

Hoashi

Saeki

2020

IJMS

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Psoriasis is a chronic inflammatory skin disease characterized by accelerated tumor necrosis factor-α/interleukin-23/interleukin-17 axis, hyperproliferation and abnormal differentiation of epidermal keratinocytes. Psoriasis patients are frequently associated with obesity, diabetes, dyslipidemia, cardiovascular diseases, or inflammatory bowel diseases. Psoriasis patients often show unbalanced dietary habits such as higher intake of fat and lower intake of fish or dietary fibers, compared to controls. Such dietary habits might be related to the incidence and severity of psoriasis. Nutrition influences the development and progress of psoriasis and its comorbidities. Saturated fatty acids, simple sugars, red meat, or alcohol exacerbate psoriasis via the activation of nucleotide-binding domain, leucine-rich repeats containing family, pyrin domain-containing-3 inflammasome, tumor necrosis factor-α/interleukin-23/interleukin-17 pathway, reactive oxygen species, prostanoids/leukotrienes, gut dysbiosis or suppression of regulatory T cells, while n-3 polyunsaturated fatty acids, vitamin D, vitamin B12, short chain fatty acids, selenium, genistein, dietary fibers or probiotics ameliorate psoriasis via the suppression of inflammatory pathways above or induction of regulatory T cells. Psoriasis patients are associated with dysbiosis of gut microbiota and the deficiency of vitamin D or selenium. We herein present the update information regarding the stimulatory or regulatory effects of nutrients or food on psoriasis and the possible alleviation of psoriasis by nutritional strategies.

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Genistein modulates gene activity in psoriatic patients

Cited by 9 publications

References 23 publications

Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations

Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations

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Nutrition and Psoriasis

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