Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations

Bocheńska, Katarzyna; Moskot, Marta; Smolińska-Fijołek, Elwira; Jakóbkiewicz‐Banecka, Joanna; Szczerkowska‐Dobosz, Aneta; Słomiński, Bartosz; Gabig-Cimińska, Magdalena

doi:10.1038/s41598-021-97793-4

Cited by 11 publications

(4 citation statements)

References 47 publications

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“…At dosages of 16 mg/kg body weight, very few investigations have found any potential mild toxicity (clinically exhibited, such as nausea, pedal oedema, or breast soreness) [151] . When applied topically to the skin, genistein has been demonstrated to be modestly absorbed (with pH 6 buffer absorbing it the most) and to have essentially no negative effects, such as erythema or disturbance of the stratum corneum [152,153] . A study on the pharmaceutical formulation of genistein indicated that genistein HME (hot melt extrusion) was safe at doses of up to 3000 mg.…”

Section: Dosing and Toxicitymentioning

confidence: 99%

Comprehensive Review on Mechanistic Insights, Optimal Dosages, and Safety Prospective of Natural Products in Anticancer Therapeutics

Chaudhry,

Zeenia,

Akim

et al. 2024

fds

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Cancer remains a formidable global health challenge, necessitating sustained research efforts to develop innovative and efficacious therapeutic modalities. The exploration of alternative cancer therapies has gained prominence, given the adverse side effects associated with conventional treatments like chemotherapy. Natural medicines, particularly those derived from botanical sources, emerge as a potentially more viable option for cancer treatment within the confines of therapeutic and safe dosage parameters. This comprehensive review elucidates the effective mechanisms and safety profiles related to the dosage of these natural compounds. The literature under consideration spans and has been meticulously curated from reputable databases, including PubMed, Scopus, and Google Scholar. Noteworthy natural substances encompassed in this scrutiny include gossypol, curcumin, resveratrol, genistein, anthocyanin, and hispidulin. The review outlines their respective mechanisms, therapeutic dosages, and safety perspectives within the context of cancer treatment. These compounds manifest diverse anticancer effects, ranging from the induction of apoptosis and inhibition of cell proliferation to the modulation of crucial signaling pathways. These natural compounds exhibit promising anticancer potential by targeting key facets of cancer progression, notably by i) instigating apoptosis and ii) intervening in cell cycle checkpoints. However, a more strategic and nuanced investigation is imperative to fully elucidate their optimal dosages, modes of action, and potential synergies with existing cancer treatment modalities. This critical gap in our understanding underscores the necessity for further in-depth research to optimize the therapeutic potential of these plant-derived chemicals.

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Section: Dosing and Toxicitymentioning

confidence: 99%

Comprehensive Review on Mechanistic Insights, Optimal Dosages, and Safety Prospective of Natural Products in Anticancer Therapeutics

Chaudhry,

Zeenia,

Akim

et al. 2024

fds

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show abstract

“…In vitro models observed the impact of genistein (a soy-derived isoflavone known for its anti-inflammatory properties) on psoriatic cells [86]. Different studies on the dietary effects of PsA focused on omega-3 and omega-6 fatty acids, reporting that certain genetic profiles might reduce the risk of PsA in the presence of a high dietary intake of omega-3 [87].…”

Section: Genetic and Pathogenetic Aspects Of Psoriatic Arthritismentioning

confidence: 99%

Psoriasis and Psoriatic Arthritis—Associated Genes, Cytokines, and Human Leukocyte Antigens

Zalesak,

Danisovic,

Harsanyi

2024

Medicina

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In recent years, research has intensified in exploring the genetic basis of psoriasis (PsO) and psoriatic arthritis (PsA). Genome-wide association studies (GWASs), including tools like ImmunoChip, have significantly deepened our understanding of disease mechanisms by pinpointing risk-associated genetic loci. These efforts have elucidated biological pathways involved in PsO pathogenesis, particularly those related to the innate immune system, antigen presentation, and adaptive immune responses. Specific genetic loci, such as TRAF3IP2, REL, and FBXL19, have been identified as having a significant impact on disease development. Interestingly, different genetic variants at the same locus can predispose individuals to either PsO or PsA (e.g., IL23R and deletion of LCE3B and LCE3C), with some variants being uniquely linked to PsA (like HLA B27 on chromosome 6). This article aims to summarize known and new data on the genetics of PsO and PsA, their associated genes, and the involvement of the HLA system and cytokines.

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“…Studies have also found that the addition of dietary products that are rich in antioxidants, such as beta-carotene and flavonoids, have been shown to improve psoriasis severity. 46,47 Additional clinical studies on specific dietary interventions and other diets are warranted.…”

Section: No Additional Findingsmentioning

confidence: 99%

Review of Integrative Medical Therapies for Psoriasis: The Microbiome, Probiotics, Diet, and Mindfulness

Min,

Dulai,

Ahmad

et al. 2024

Journal of Psoriasis and Psoriatic Arthritis

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Background Psoriasis is a chronic inflammatory condition with cutaneous and systemic involvement. Although many efficacious treatment options are available, concerns regarding costs and duration of treatment have expanded interest in the role of integrative medical therapies for psoriasis. Objective In this review, we aim to provide evidence for the use of integrative medical approaches in the management of psoriasis, namely approaches utilizing the microbiome, probiotics, diet, and mindfulness. Methods PubMed/Medline and Google Scholar databases were searched from inception up to 16 August 2023 to identify clinical studies that evaluated how integrative medical therapies affect psoriasis severity. Search terms combined “psoriasis” or “psoriatic arthritis” with terms related to the microbiome, diet, and lifestyle. Results Multiple clinical studies have shown that integrative approaches can reduce psoriasis severity. Probiotic supplementation in psoriatic patients decreased PASI scores, decreased inflammatory markers, increased quality of life, and reduced the risk of disease relapse. Intermittent fasting, in the context of Ramadan, decreased PASI scores and plasma CRP levels. Low-calorie diets and low-calorie ketogenic diets have been shown to reduce psoriasis severity. Notably, combining low-calorie diets with biologics and cyclosporine synergistically improved psoriasis to a greater extent than pharmaceutical therapy alone. A gluten-free diet improved psoriasis and reduced antigliadin antibodies in those with hypersensitivity. Mindfulness therapies also improved psoriasis severity with and without phototherapy. Conclusion Several studies show that integrative medicine can be used to manage psoriasis. Specifically, probiotic supplementation, diets that promote weight loss or modulate antigliadin antibodies, and mindfulness therapies may improve disease severity.

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Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations

Cited by 11 publications

References 47 publications

Comprehensive Review on Mechanistic Insights, Optimal Dosages, and Safety Prospective of Natural Products in Anticancer Therapeutics

Comprehensive Review on Mechanistic Insights, Optimal Dosages, and Safety Prospective of Natural Products in Anticancer Therapeutics

Psoriasis and Psoriatic Arthritis—Associated Genes, Cytokines, and Human Leukocyte Antigens

Review of Integrative Medical Therapies for Psoriasis: The Microbiome, Probiotics, Diet, and Mindfulness

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