Nutrition and Psoriasis

Kanda, Naoko; Hoashi, Toshihiko; Saeki, Hidehisa

doi:10.3390/ijms21155405

Cited by 87 publications

(110 citation statements)

References 124 publications

(154 reference statements)

Supporting

Mentioning

106

Contrasting

Unclassified

Order By: Relevance

“…The lower intake of vitamin A was weakly (odds ratio 0.998) but significantly associated with PPP. Dietary vitamin A is absorbed in the intestine, delivered to the liver and stocked, further carried to target tissues where it is metabolized to active retinoic acid 22 . Retinoic acid binds retinoic acid receptor, which further interacts with retinoid X receptor, and the receptor dimers activate or repress the expression of target genes 38 .…”

Section: Discussionmentioning

confidence: 99%

“…Saturated fatty acids, red meat, simple sugars, or alcohol exacerbate psoriasis via the activation of TNF‐α/IL‐23/IL‐17 axis, gut dysbiosis or suppression of regulatory T cells (Tregs). In contrast, n ‐3 polyunsaturated fatty acids, vitamin D, vitamin B12, dietary fibers, or probiotics ameliorate psoriasis via the suppression of the above inflammatory pathways or the induction of Tregs 22 . We recently examined the dietary habits in Japanese patients with psoriasis, and found that they consumed more sugar/sweeteners compared to controls, and patients with high psoriasis area and severity index (PASI) showed higher intake of confections compared to those with low PASI, indicating the involvement of high sugar intake in the exacerbation of psoriasis 20 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dietary habits in Japanese patients with palmoplantar pustulosis

Serizawa

Okazaki

Otsuka

et al. 2021

The Journal of Dermatology

Self Cite

View full text Add to dashboard Cite

Palmoplantar pustulosis (PPP) is a chronic dermatitis characterized by sterile intra‐epidermal pustules associated with erythema and scales on the palms and soles. Tumor necrosis factor (TNF)‐α/interleukin (IL)‐23/IL‐17 inflammatory pathway may be involved in the pathogenesis of PPP, and the skin lesions manifest the enhanced expression of IL‐8 in keratinocytes and increased levels of antimicrobial peptide cathelicidin, leucine leucine‐37 in vesicles/pustules. Some PPP patients are associated with arthro‐osteitis, called pustulotic arthro‐osteitis (PAO). Dietary habits may modulate the pathogenesis of PPP, however, have not been investigated in PPP patients. We evaluated dietary habits in adult Japanese PPP patients, using a validated, brief‐type self‐administered diet history questionnaire, and compared their results to those of age‐ and sex‐matched healthy controls. The results in PPP patients with PAO were compared to those in the patients without. Japanese PPP patients showed higher body mass indices (BMIs), higher intakes of pulses and sugar/sweeteners, and lower intake of vitamin A, compared to those of healthy controls. The bivariate and multivariable logistic regression analysis showed that PPP was associated with high BMI, high intake of pulses, and low intake of vitamin A. The sodium intake and BMI were positively correlated with palmoplantar pustulosis area and severity index (PPPASI). The linear multivariate regression analysis revealed that sodium intake and BMI were predictors of PPPASI. The age and sodium intake in the patients with PAO were lower than those in the patients without. The bivariate and multivariable logistic regression analysis showed that PAO was negatively associated with age and sodium intake. This is the first study showing the dietary habits in patients with PPP. Further studies should clarify if the dietary intervention to correct the BMI and sodium intake will alter the progress of PPP.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dietary habits in Japanese patients with palmoplantar pustulosis

Serizawa

Okazaki

Otsuka

et al. 2021

The Journal of Dermatology

Self Cite

View full text Add to dashboard Cite

show abstract

“…The foods most enriched in BCAAs are meat, fish, eggs, and dairy products; thus, it might be beneficial for psoriasis patients to limit their intake of these high protein diets. It was reported that psoriasis patients often show unbalanced dietary habits such as higher intake of red meat and fat but lower intake of dietary fibers 46 , 47 , exacerbating psoriasis via the activation of the nucleotide-binding domain, leucine-rich repeat-containing family, TNF-α/IL-23/IL-17 pathway and reactive oxygen species 48 , 49 . Therefore, nutritional strategies might be beneficial to relieve psoriatic symptoms and severity.…”

Section: Discussionmentioning

confidence: 99%

Metabolomic profiling reveals amino acid and carnitine alterations as metabolic signatures in psoriasis

Chen¹,

Hou²,

Ren³

et al. 2021

Theranostics

View full text Add to dashboard Cite

High-throughput metabolite profiling provides the opportunity to reveal metabolic mechanisms and identify biomarkers. Psoriasis is an immune-mediated chronic inflammatory disease. However, the role of metabolism in psoriasis pathogenesis remains unclear. Methods: Plasma samples of individuals (45 psoriasis and 45 sex‐, age-, and BMI-matched healthy controls) were collected. Non-targeted metabolomics and amino acid- or carnitine-targeted metabolomics were conducted, then, plasma samples of mice induced by imiquimod (IMQ) were subjected to the amino acid- and carnitine-targeted metabolomic profiling. Flow cytometry was used to study the effect of L-carnitine (LC(C0)) on IMQ-induced psoriatic inflammation. Results: Through the non-targeted metabolomics approach, we detected significantly altered amino acids and carnitines in psoriasis patients. Amino acid-targeted metabolomic profiling identified 37 amino acids altered in psoriasis, of these 23 were markedly upregulated, including essential amino acids (EAAs), and branched-chain amino acids (BCAAs), whereas glutamine, cysteine, and asparagine were significantly down-regulated. Carnitine-targeted metabolomic profiling identified 40 significantly altered carnitines, 14 of which included palmitoylcarnitine (C16) and were markedly downregulated in psoriasis, whereas hexanoylcarnitine (C6) and 3-OH-octadecenoylcarnitine (C18:1-OH) were significantly upregulated. Interestingly, glutamine, asparagine, and C16 levels were negatively correlated with the PASI score. Moreover, a higher abundance of LC(C0) was associated with markedly reduced IMQ-induced epidermal thickening and infiltration of Th17 cells in skin lesions, indicating LC(C0) supplementation as a potential therapy for psoriasis treatment. Conclusion: Our results suggested the metabolism of amino acids and carnitines are significantly altered in psoriasis, especially the metabolism of EAAs, BCAAs, and LC(C0), which may play key roles in the pathogenesis of psoriasis.

show abstract

“…The association between Pso and OP is therefore supported by the existence of pathophysiological mechanisms, namely, excessive production of proinflammatory cytokines that are able to activate osteoclastogenesis, and the frequent lack of vitamin D characterizing psoriatic patients ( 55 , 56 ).…”

Section: Pathogenic Mechanisms Linking Pso and Opmentioning

confidence: 99%

IL-33/Vitamin D Crosstalk in Psoriasis-Associated Osteoporosis

et al. 2021

View full text Add to dashboard Cite

Patients with psoriasis (Pso) and, in particular, psoriatic arthritis (PsoA) have an increased risk of developing osteoporosis (OP). It has been shown that OP is among the more common pathologies associated with Pso, mainly due to the well-known osteopenizing conditions coexisting in these patients. Pso and OP share common risk factors, such as vitamin D deficiency and chronic inflammation. Interestingly, the interleukin (IL)-33/ST2 axis, together with vitamin D, is closely related to both Pso and OP. Vitamin D and the IL-33/ST2 signaling pathways are closely involved in bone remodeling, as well as in skin barrier pathophysiology. The production of anti-osteoclastogenic cytokines, e.g., IL-4 and IL-10, is promoted by IL-33 and vitamin D, which are stimulators of both regulatory and Th2 cells. IL-33, together with other Th2 cytokines, shifts osteoclast precursor differentiation towards macrophage and dendritic cells and inhibits receptor activator of nuclear factor kappa-B ligand (RANKL)-induced osteoclastogenesis by regulating the expression of anti-osteoclastic genes. However, while the vitamin D protective functions in OP and Pso have been definitively ascertained, the overall effect of IL-33 on bone and skin homeostasis, because of its pleiotropic action, is still controversial. Emerging evidence suggests a functional link between vitamin D and the IL-33/ST2 axis, which acts through hormonal influences and immune-mediated effects, as well as cellular and metabolic functions. Based on the actions of vitamin D and IL-33 in Pso and OP, here, we hypothesize the role of their crosstalk in the pathogenesis of both these pathologies.

show abstract

Nutrition and Psoriasis

Cited by 87 publications

References 124 publications

Dietary habits in Japanese patients with palmoplantar pustulosis

Dietary habits in Japanese patients with palmoplantar pustulosis

Metabolomic profiling reveals amino acid and carnitine alterations as metabolic signatures in psoriasis

IL-33/Vitamin D Crosstalk in Psoriasis-Associated Osteoporosis

Contact Info

Product

Resources

About