IL-33/Vitamin D Crosstalk in Psoriasis-Associated Osteoporosis

Martinis, Massimo De; Ginaldi, Lia; Sirufo, Maria Maddalena; Bassino, Enrica Maria; Pietro, Francesca De; Pioggia, Giovanni; Gangemi, Sebastiano

doi:10.3389/fimmu.2020.604055

Cited by 21 publications

(16 citation statements)

References 130 publications

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“…5 Journal of Immunology Research the production of Th2 cytokines IL-4 and IL-10 was promoted by IL-33 [18], and Th2 immune response was described to influence the pathogenesis of respiratory syncytial virus (RSV) acute bronchiolitis [19]. Firstly, the expression of IL-33 in serum of acute bronchiolitis infants infected by RSV was examined by ELISA assay; we found that IL-33 concentrations in AVB infants were significantly increased compared to normal subjects (Figure 1(a)).…”

Section: Resultsmentioning

confidence: 99%

Inhibition of NF-κB/IL-33/ST2 Axis Ameliorates Acute Bronchiolitis Induced by Respiratory Syncytial Virus

Zhang

Wan

et al. 2021

Journal of Immunology Research

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Background/Aim. Bronchiolitis is a common acute lower respiratory tract infectious disease in infants. Respiratory syncytial virus (RSV) infection is one of the main causes. Bronchiolitis can lead to a significant increase in the incidence of asthma in young children, but the mechanism of bronchiolitis transforming into asthma is still unclear. The study was aimed at investigating the role of NF-κB/IL-33/ST2 axis on RSV-induced acute bronchiolitis. Methods. A total of 40 infants diagnosed with acute bronchiolitis infected by RSV, and 20 normal infants were included in this study. BALB/c mice (6-8 weeks old, 20 ± 1.1 g) were used as study models. Enzyme-linked immunosorbent assay (ELISA), quantitative real time PCR, western blot analysis, immunohistochemical staining, and flow cytometry analysis were performed to examine relevant indicators. Results. IL-33 level was significantly elevated, and Th1/Th2 ratio is imbalance after in infants with acute bronchiolitis. In vivo study, we found that NF-κB/IL-33/ST2 axis is mediated the Th2 cytokine levels and BAL cell number induced by RSV. Acute bronchiolitis induced by RSV in a mouse model is attenuated after inhibition of NF-κB/IL-33/ST2 pathway. Moreover, we also confirmed that macrophages are important sources of IL-33 and are regulated by NF-κB pathway in RSV-induced mice. Conclusion. We confirmed that inhibition of NF-κB/IL-33/ST2 axis could attenuate acute bronchiolitis by RSV infected. Our findings not only demonstrate the potential role of IL-33 antibody in attenuating RSV-induced lung damage but also provide a new insight into better prevention of RSV-induced asthma by mediating NF-κB/IL-33/ST2 axis.

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Section: Resultsmentioning

confidence: 99%

Inhibition of NF-κB/IL-33/ST2 Axis Ameliorates Acute Bronchiolitis Induced by Respiratory Syncytial Virus

Zhang

Wan

et al. 2021

Journal of Immunology Research

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“…1,25(OH) 2 D is shown to abrogate the osteoclastogenic potential and proinflammatory cytokine secretion capacity of immune cells of patients with psoriasis and PsA [ 92 , 93 , 94 ]. This could explain the observation that serum 25(OH)D was inversely correlated with presence of PsA [ 95 ], as well as plasma C-reactive protein level among patients with PsA [ 96 ].…”

Section: Evidence On Vitamin D For Prevention and Treatment Of Rheumatic Diseasesmentioning

confidence: 99%

Vitamin D and Rheumatic Diseases: A Review of Clinical Evidence

Charoenngam

2021

IJMS

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Vitamin D plays an important role in maintaining a healthy mineralized skeleton. It is also considered an immunomodulatory agent that regulates innate and adaptive immune systems. The aim of this narrative review is to provide general concepts of vitamin D for the skeletal and immune health, and to summarize the mechanistic, epidemiological, and clinical evidence on the relationship between vitamin D and rheumatic diseases. Multiple observational studies have demonstrated the association between a low level of serum 25-hydroxyvitamin D [25(OH)D] and the presence and severity of several rheumatic diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), spondyloarthropathies, and osteoarthritis (OA). Nevertheless, the specific benefits of vitamin D supplements for the treatment and prevention of rheumatic diseases are less accepted as the results from randomized clinical trials are inconsistent, although some conceivable benefits of vitamin D for the improvement of disease activity of RA, SLE, and OA have been demonstrated in meta-analyses. It is also possible that some individuals might benefit from vitamin D differently than others, as inter-individual difference in responsiveness to vitamin D supplementation has been observed in genomic studies. Although the optimal level of serum 25(OH)D is still debatable, it is advisable it is advisable that patients with rheumatic diseases should maintain a serum 25(OH)D level of at least 30 ng/mL (75 nmol/L) to prevent osteomalacia, secondary osteoporosis, and fracture, and possibly 40–60 ng/mL (100–150 nmol/L) to achieve maximal benefit from vitamin D for immune health and overall health.

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“…Vitamin D, in fact, is important in the maintenance of bone health through the regulation of serum calcium homeostasis. The lack of vitamin D increases bone resorption in order to maintain the right serum calcium levels, making up for the lack of calcium reabsorbed by the gut induced by vitamin D deficiency [ 112 ].…”

Section: Discussionmentioning

confidence: 99%

The Microbiota-Bone-Allergy Interplay

Sirufo

Pietro

Catalogna

et al. 2021

IJERPH

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Emerging knowledge suggests an increasing importance of gut microbiota in health and disease. Allergy and bone metabolism are closely interconnected, and the possible negative effects of common therapies are not the only aspects of this relationship. The immune system is influenced by the microbiota-host interactions, and several pieces of evidence suggest the existence of an interplay between microbiota, bone metabolism, and allergies. Understanding these inter-relationships is essential for the development of new potential strategies of treatment and prevention targeting microbiota. A wide range of substances and germs, prebiotics and probiotics, are capable of influencing and modifying the microbiota. Prebiotics and probiotics have been shown in several studies to have different actions based on various factors such as sex, hormonal status, and age. In this review, we summarize the latest knowledge on the topic, and we discuss practical implications and the need for further studies.

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IL-33/Vitamin D Crosstalk in Psoriasis-Associated Osteoporosis

Cited by 21 publications

References 130 publications

Inhibition of NF-κB/IL-33/ST2 Axis Ameliorates Acute Bronchiolitis Induced by Respiratory Syncytial Virus

Inhibition of NF-κB/IL-33/ST2 Axis Ameliorates Acute Bronchiolitis Induced by Respiratory Syncytial Virus

Vitamin D and Rheumatic Diseases: A Review of Clinical Evidence

The Microbiota-Bone-Allergy Interplay

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