Genetics and Epigenetics of Aging and Longevity

Moskalev, A A

doi:10.17816/ecogen1113-11

Cited by 31 publications

(32 citation statements)

References 82 publications

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“…The longevity correlates with stress resistance [50,51]. Our experiments showed the increase of resistance to oxidative stress and activation of expression of stress response genes, including the FOXO target genes; however, in flies, the transcriptional activity of FOXO gene after carotenoid treatment was reduced.…”

Section: Discussionmentioning

confidence: 63%

Fucoxanthin increases lifespan of Drosophila melanogaster and Caenorhabditis elegans

Lashmanova

Proshkina

Zhikrivetskaya

et al. 2015

Pharmacological Research

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Section: Discussionmentioning

confidence: 63%

Fucoxanthin increases lifespan of Drosophila melanogaster and Caenorhabditis elegans

Lashmanova

Proshkina

Zhikrivetskaya

et al. 2015

Pharmacological Research

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“…Among them are genes hypothetically related to ribosomal RNA, metabolic processes (Zinc fingers), ERK signaling and cytoskeleton remodeling (ACTB), detoxification of reactive oxygen species, ubiquitination, proliferation, differentiation, and carcinogenesis (PRDX3, CALR), immune response (histocompatibility complex class II and extended class II sub-region, NDRG1, PTMA, GPS2), mitochondria, ATP metabolism and iron binding (PAH, CYP1A1), senescence and autophagy in cancer (CREG1, CAAX box protein), lipoprotein and cholesterol metabolic process (APOA2), regulation of cell differentiation, serpin family (SERPINF2). Interestingly, many of above-mentioned genes are involved in aging associated pathways [17][18][19] .…”

Section: Unknown Genesmentioning

confidence: 99%

Gray whale transcriptome reveals longevity adaptations associated with DNA repair and ubiquitination

Toren

Kulaga

Jethva

et al. 2019

Preprint

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One important question in aging research is how differences in genomics and transcriptomics determine maximum lifespan in various species. Despite recent progress, much is still unclear on the topic, partly due to the lack of samples in non-model organisms and due to challenges in direct comparisons of transcriptomes from different species. The novel ranking-based method that we employ here is used to analyze gene expression in the gray whale and compare its de novo assembled transcriptome with that of other long-and short-lived mammals. Gray whales are among the top 1% longest-lived mammals. Despite the extreme environment, or maybe due to a remarkable adaptation to its habitat (intermittent hypoxia, Arctic water and high pressure), gray whales reach at least the age of 77 years. In this work, we show that long-lived mammals share common gene expression patterns between themselves, including high expression of DNA maintenance and repair, autophagy, ubiquitination, apoptosis, and immune responses.Additionally, the level of expression for gray whale orthologs of pro-and anti-longevity genes found in model organisms is in support of their alleged role and direction in lifespan determination. Remarkably, among highly expressed pro-longevity genes many are stress-related, reflecting an adaptation to extreme environmental conditions. The conducted analysis suggests that the gray whale potentially possesses high resistance to cancer and stress, at least in part ensuring its longevity. This new transcriptome assembly also provides important resources to support the efforts of maintaining the endangered population of gray whales.

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“…8 Yaşlanma sırasında gen ifadesini önemli öl-çüde etkileyen epigenetik mekanizmalar arasında, DNA metilasyonu, histon modifikasyonları ve kodlamayan RNA'lar yer almaktadır. 10 Model organizmalarla (maya, solucan, sinek vb) yapılan çalışmalar epigenetik faktörler ve yaş-lanma arasındaki bağlantıyla ilgili belirli ipuçları sağlamıştır. Ancak, memelilerde epigenetiğin hangi mekanizma ile yaşlanmayı uyardığı ve aynı zamanda yaşa bağlı olarak meydana gelen hastalık-lardaki rolü tam olarak tanımlanmamıştır.…”

Section: Yaşlanma Ve Yaşlanmayla İlişkili Hastalıklardaki Epigenetik unclassified

“…58 miRNA'lar, posttranskripsiyonel gen ifadesini kontrol ederek normal fizyolojik gelişim ve hastalıkların patogenezinde rol alırlar. 10 Birikmiş genomik kararsızlık yaşlanma sürecinde önemli faktör olarak kabul edilir. Hücresel strese yanıt olarak indüklenen miRNA'lar DNA onarımında yer alan protein seviyelerinin azalmasına yol açar.…”

Section: Kromati̇n Yeni̇den şEki̇llenmesi̇ Ve Yaşlanmaunclassified

Epigenetic Alterations in Aging and Aging-Associated Diseases: Review

Güneş¹,

Bayramov²

2016

Turkiye Klinikleri J Med Sci

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Genetics and Epigenetics of Aging and Longevity

Cited by 31 publications

References 82 publications

Fucoxanthin increases lifespan of Drosophila melanogaster and Caenorhabditis elegans

Fucoxanthin increases lifespan of Drosophila melanogaster and Caenorhabditis elegans

Gray whale transcriptome reveals longevity adaptations associated with DNA repair and ubiquitination

Epigenetic Alterations in Aging and Aging-Associated Diseases: Review

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