Fucoxanthin increases lifespan of Drosophila melanogaster and Caenorhabditis elegans

Lashmanova, Ekaterina; Proshkina, Ekaterina; Zhikrivetskaya, Svetlana; Шевченко, О. Г.; Marusich, Elena; Leonov, Sergey; Melerzanov, Alex; Zhavoronkov, Alex; Moskalev, Alexey

doi:10.1016/j.phrs.2015.08.009

Cited by 60 publications

(56 citation statements)

References 90 publications

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“…Figure S7; note that data for the mock-treated WT strain and for the WT strain cultured with PE4 are replicated in all graphs of this figure). Such changes in the values of α and MRDT are characteristic of interventions that decrease the rate of biological aging [79–83]. Thus, PE4 delays yeast chronological aging independently of the pro-aging PKA pathway, the pro-aging PKH1/2 pathway or the pro-aging protein kinase Sch9.…”

Section: Resultsmentioning

confidence: 99%

Six plant extracts delay yeast chronological aging through different signaling pathways

et al. 2016

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Our recent study has revealed six plant extracts that slow yeast chronological aging more efficiently than any chemical compound yet described. The rate of aging in yeast is controlled by an evolutionarily conserved network of integrated signaling pathways and protein kinases. Here, we assessed how single-gene-deletion mutations eliminating each of these pathways and kinases affect the aging-delaying efficiencies of the six plant extracts. Our findings imply that these extracts slow aging in the following ways: 1) plant extract 4 decreases the efficiency with which the pro-aging TORC1 pathway inhibits the anti-aging SNF1 pathway; 2) plant extract 5 mitigates two different branches of the pro-aging PKA pathway; 3) plant extract 6 coordinates processes that are not assimilated into the network of presently known signaling pathways/protein kinases; 4) plant extract 8 diminishes the inhibitory action of PKA on SNF1; 5) plant extract 12 intensifies the anti-aging protein kinase Rim15; and 6) plant extract 21 inhibits a form of the pro-aging protein kinase Sch9 that is activated by the pro-aging PKH1/2 pathway.

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Section: Resultsmentioning

confidence: 99%

Six plant extracts delay yeast chronological aging through different signaling pathways

et al. 2016

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“…This model possesses many advantages in research, with more than 65% of the human diseases-related genes conserved 26 . Among the characteristic components of Xanthigen® , there are previous studies of the role of fucoxanthin increasing lifespan of C. elegans 27 , and also others recent about the beneficial effects of pomegranate extracts in different organisms including worms 28 .…”

Section: Discussionmentioning

confidence: 99%

Xanthigen® reduces lipid deposition and improves stress resistance in Caenorhabditis elegans

Clavijo¹,

López-Ríos²,

Pérez-Machín³

et al. 2020

JHMR

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“… 31 , 32 Flavonoids as well as phytoestrogens have been reported to increase the life span of Drosophila melanogaster and Caenorhabditis elegans . 33 , 34 , 35 Concerning oxidative, stress it is still unclear whether the degenerating neurons themselves or misfolded proteins directly result in toxicity. The degenerating neurons also produce endogenous toxins and other reactive oxygen species that may further damage normal neurons.…”

Section: Discussionmentioning

confidence: 99%

Alteration in biochemical parameters in the brain of transgenic Drosophila melanogaster model of Parkinson’s disease exposed to apigenin

Siddique

Jyoti

2017

Integrative Medicine Research

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BackgroundOxidative stress is one of the key components of the pathology of various neurodegenerative disorders. Parkinson’s disease (PD) is characterized by the progressive loss of dopaminergic neurons owing to the aggregation of alpha-synuclein (αS) in the brain. A number of polyphenols have been reported to inhibit the αS aggregation resulting in the possible prevention of PD. The involvement of free radicals in mediating the neuronal death in PD has also been implicated.MethodsIn the present study, the transgenic flies expressing human αS in the brain were exposed to 10 μM, 20 μM, 40 μM, and 80 μM of apigenin established in diet for 24 days.ResultsThe flies showed an increase in life span, glutathione, and dopamine content. The exposure of PD flies to various doses of apigenin also results in the reduction of glutathione-S-transferase activity, lipid peroxidation, monoamine oxidase, caspase-3, and caspase-9 activity in a dose-dependent manner.ConclusionThe results of the present study reveal that apigenin is potent in increasing the life span, dopamine content, reduced the oxidative stress as well as apoptosis in transgenic Drosophila model of PD.

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Fucoxanthin increases lifespan of Drosophila melanogaster and Caenorhabditis elegans

Cited by 60 publications

References 90 publications

Six plant extracts delay yeast chronological aging through different signaling pathways

Six plant extracts delay yeast chronological aging through different signaling pathways

Xanthigen® reduces lipid deposition and improves stress resistance in Caenorhabditis elegans

Alteration in biochemical parameters in the brain of transgenic Drosophila melanogaster model of Parkinson’s disease exposed to apigenin

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