Genetically Determined Body Weight Loss in Mice Fed Diets Containing Salmon Oil

LeBoeuf, Renée C.; Veldee, Megan S.

doi:10.1093/jn/123.3.547

Cited by 14 publications

(8 citation statements)

References 32 publications

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“…Food intake was estimated from the difference in food remaining in the food trough and the cage (separated from bedding by sifting) between the afternoon when food was given and the next day when food troughs were replaced. The total amount of food eaten by 5 mice per cage were averaged over 3-day periods during week 3 and 7 [13].…”

Section: Diets and Feedingmentioning

confidence: 99%

Initiation of Hyperinsulinemia and Hyperleptinemia is Diet Dependent in C57BL/6 Mice

Harte¹,

Kirk²,

Rosenfeld³

et al. 1999

Horm Metab Res

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C57BL/6 female mice were fed high fat diets containing different types of carbohydrate (sucrose or corn starch) and contents of cholesterol (0.03 % or 1 %) to identify early metabolic changes leading to increases in leptin levels and eventual insulin resistance. Under identical dietary fat conditions, type of carbohydrate and cholesterol content contributed to the timing of leptin increases. Mice fed a high-fat, high-sucrose diet showed early (4 weeks) and robust increases in circulating insulin and leptin levels (2-fold and 5-fold, respectively). In contrast, mice fed this diet with added cholesterol or with sucrose substituted by corn starch led to marked delays (8-10 weeks) in the elevations of insulin and leptin, although body weight gains were nearly identical among test diet groups. Thus, sucrose in combination with saturated fat played a specific role in initiating early metabolic changes associated with elevated leptin and insulin levels. Because leptin levels were most reflective of changes in insulin, our data support a role for insulin in determining plasma leptin levels in mice.

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Section: Diets and Feedingmentioning

confidence: 99%

Initiation of Hyperinsulinemia and Hyperleptinemia is Diet Dependent in C57BL/6 Mice

Harte¹,

Kirk²,

Rosenfeld³

et al. 1999

Horm Metab Res

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“…2 Only two other studies show a reduction in energy intake with ®sh oil. 3,5 These data suggest that dietary fatty acids of the n-3 series could modulate to some extent the partitioning of fat between oxidation and storage.…”

Section: Introductionmentioning

confidence: 99%

Effect of dietary fish oil on body fat mass and basal fat oxidation in healthy adults

et al. 1997

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OBJECTIVE: To investigate whether the substitution of ®sh oil for visible fats in a control diet (52% carbohydrates, 16% protein, 32% fat; P:S 0.2) in¯uences body fat mass and substrate oxidation in healthy adults. DESIGN: Six volunteers (5 men; 23 AE 2 y; BMI: 21.9 AE 1.6) were fed a control diet (C) ad libitum during a period of three weeks and, 10±12 weeks later, the same diet where 6 g/d of visible fat were replaced by 6 g/d of ®sh oil (FO) for another three weeks. RESULTS: Energy intakes (IKA-calorimeter) were unchanged. Body fat mass (Dual-energy X-ray absorptiometry) decreased with FO (70.88 AE 0.16 vs 70.3 AE 0.34 kg; FO vs C; P`0.05). When adjusted for lean body mass (Ancova), resting metabolic rate (indirect calorimetry) was unchanged. Basal respiratory quotient decreased with FO (0.815 AE 0.02 vs 0.834 AE 0.02; P`0.05) and basal lipid oxidation increased with FO (1.06 AE 0.17 vs 0.87 AE 0.13 mg kg 71 min 71 ; P`0.05). CONCLUSION: Dietary FO reduces body fat mass and stimulates lipid oxidation in healthy adults.

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“…Inhibiting effects of fish oil on food intake compared with corn oil and olive oil were described in rodents 14, 23, 24. The mechanism involved may increase oxidative stress and tissue damage due to the highly unsaturated nature of LPUFA 9, 25.…”

Section: Discussionmentioning

confidence: 99%

Long‐chain fatty acid supplemented infant formula does not influence calcium and magnesium bioavailability in weanling rats

Vaquero

Sarriá

2005

J Sci Food Agric

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The influence of infant formula supplementation with long-chain-polyunsaturated fatty acids (LCPUFA) on calcium and magnesium bioavailability was assessed in rats. Two test diets containing a plain, unsupplemented (PF) or supplemented (SF) infant formula as the fat source and a control diet (C) were administered to weaning rats and food intake and body weight gain were monitored for 28 days. In order to assess calcium and magnesium bioavailability, during the last week faeces and urine were collected and apparent absorption and retention were calculated. Food intake and body weight showed no significant differences between PF and SF but were lower in both groups compared with C. Calcium and magnesium intake did not differ between PF and SF, although both parameters were lower compared with C. Calcium absorption efficiency in PF and SF was significantly higher than in C. However, both groups showed higher urinary calcium excretion and thus no differences were observed in calcium retention. Magnesium absorption efficiency was also significantly higher in PF and SF compared with C, but magnesium absorption was significantly lower in SF compared with PF and C. Nevertheless, urinary magnesium excretion and magnesium retention were similar in the three groups. The consumption of a diet containing an infant formula supplemented with LCPUFA compared with the plain formula does not affect calcium and magnesium bioavailability in rats.

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Genetically Determined Body Weight Loss in Mice Fed Diets Containing Salmon Oil

Cited by 14 publications

References 32 publications

Initiation of Hyperinsulinemia and Hyperleptinemia is Diet Dependent in C57BL/6 Mice

Initiation of Hyperinsulinemia and Hyperleptinemia is Diet Dependent in C57BL/6 Mice

Effect of dietary fish oil on body fat mass and basal fat oxidation in healthy adults

Long‐chain fatty acid supplemented infant formula does not influence calcium and magnesium bioavailability in weanling rats

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