Genetic variations in the leptin gene associated with growth and carcass traits in Nellore cattle

Abstract

ABSTRACT. The aim of the study was to detect polymorphisms in the leptin gene and to determine the association of these polymorphisms with growth and carcass traits in Nellore cattle. The single nucleotide polymorphisms (SNPs) -1457 (AJ571671:g.-1457A>G) and A59V (AF536174.1:g. 321C>T), as well as the microsatellite BM1500 (3.9 kb downstream), were genotyped. The measures of body weight and ultrasound examinations (rib eye area, back, and rump fat thickness) were performed in 3 different periods of animal management. During the first period, the animals were fed with grass and mineralized salt ad libitum. In the second period, they received grass and concentrate, and in the third, only concentrate. After the slaughter of animals, data were collected for classification and typification of carcasses. No significant association was found between the variables assessed and SNP -1457. Conversely, SNP A59V was associated with rump fat thickness and muscle color post-slaughter. BM1500 was associated with rump fat thickness in the first period (pre-slaughter), subcutaneous fat thickness 3003 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 13 (2): 3002-3012 (2014) Leptin gene variations in Nellore cattle in the second, weight of the animals in the third, and length of the carcass after slaughter. These results suggest that SNP A59V and the microsatellite BM1500 might be useful for marker-assisted selection in Nellore cattle.

Individual and combined effects of <i>CAPN1</i>, <i>CAST</i>, <i>LEP</i> and <i>GHR</i> gene polymorphisms on carcass characteristics and meat quality in Holstein bulls

“…The polymorphism A80V of the LEP gene has been reported as an effective marker on weight and average daily body weight gains (Kulig and Kmieć, 2009), marbling and carcass traits in feedlot cattle (Geary et al, 2003;Silva et al, 2014). However, there was no association between the LEP A80V polymorphism and any of the phenotypic traits evaluated in the current study.…”

The novel SNPs of leptin gene and their associations with growth traits in Chinese Nanjiang Yellow goat

“…Subsequently, significant associations were revealed between the exon 2 polymorphisms of the LEP gene and the carcass fat distribution, the intensity of red muscle coloration, pH, marbling, and post-slaughter fat thickness traits in Nellore cattle (de Oliveira et al, 2013). Likewise, the other two LEP SNPs (g.− 1457A N C and g.321C N T) were identified in Nellore cattle, and the sense mutation (g.321C N T) was associated with rump fat thickness and muscle color post-slaughter (Silva et al, 2014). It has also been shown that the LEP gene associates with carcass yield and meat quality in beef cattle Tian et al, 2013).…”

Identifying polymorphism in some genes and their effects on growth performance in Honamli and hair goat breeds

“…WANG et al, (2015) have found six novel mutations in LEP gene, which have been associated with growth traits in six native Chinese goat breeds. On the other hand, some SNPs have been found to be associated growth traits in cattle (YANG et al, 2007;SILVA et al, 2014). In terms of SNPs examined in LEP gene, Honamli and Hair goat breeds were found monomorphic.…”

“…The growth is affected by many factors such as genetics, litter size, sex and environment in small ruminants. There are many of studies on different potential candidate genes related with growth-associated traits in varied livestock breeds, among these genes are GH, POU1F1, LEP, MSTN and BMP15 (SILVA et al, 2014;AN et al, 2011;SELVAGGI et al, 2011;LI et al, 2008).…”