Genetic variants of resistin and its plasma levels: Association with obesity and dyslipidemia related to type 2 diabetes susceptibility

Rathwa, Nirali; Patel, Roma; Palit, Sayantani Pramanik; Ramachandran, A. V.; Begum, Rasheedunnisa

doi:10.1016/j.ygeno.2018.06.005

Cited by 22 publications

(17 citation statements)

References 40 publications

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“…SNPs are found in the RETN promoter and 3'-untranslated regions [14]. Genetic variation at the RETN locus carries a risk of several diseases, including the metabolic syndrome and colon cancer [15,16] and those with a functional RETN gene polymorphism at -420 (rs1862513) are at risk of developing type 2 diabetes [17,18], and associated with obesity in Tunisian population [19]. RETN SNPs have been found to correlated with worsening disease in Chinese Han patients with lung cancer [20].…”

Section: Ivyspringmentioning

confidence: 99%

Impacts of RETN genetic polymorphism on breast cancer development

et al. 2020

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The adipokine resistin is linked with obesity, inflammation and various cancers, including breast cancer. This study sought to determine whether certain polymorphisms in the gene encoding resistin, RETN, increase the risk of breast cancer susceptibility. We analyzed levels of resistin expression in breast cancer tissue and samples from The Cancer Genome Atlas database. We also examined associations between four RETN single nucleotide polymorphisms (SNPs; rs3745367, rs7408174, rs1862513 and rs3219175) and breast cancer susceptibility in 515 patients with breast cancer and 541 healthy women without cancer. Compared with wild-type (GG) carriers, those carrying the AG genotype of the RETN SNP rs3219175 and those carrying at least one A allele in the SNP rs3219175 had a higher chance of developing breast cancer (adjusted odds ratio, AOR: 1.295, 95% confidence intervals, CI: 1.065-1.575 and 2.202, 1.701-2.243, respectively). When clinical aspects and the RETN SNP rs7408174 were examined in the breast cancer cohort, the CT genotype was linked to late-stage disease, while women with luminal A disease and at least one C allele were likely to progress to stage III/IV disease and to develop highly pathological grade III disease. Moreover, resistin-positive individuals were at greater risk than resistin-negative individuals for developing pathological grade III disease (OR: 5.020; 95% CI: 1.380-18.259). This study details risk associations between resistin and RETN SNPs in breast cancer susceptibility in Chinese Han women.

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Section: Ivyspringmentioning

confidence: 99%

Impacts of RETN genetic polymorphism on breast cancer development

et al. 2020

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“…These findings also suggest the association of +276G/T (rs1501299) with Non-Alcoholic Fatty Liver Disease (NAFLD), co-morbidity associated with T2D as supported by Wang et al 43 . Additionally, we have also found increased levels of TNFα, Free Fatty Acids (FFA) and resistin in obese patients 17,44 . Since TNFα is shown to be an important regulator of adiponectin multimerization 45 , our observations of increased TNFα, reduced adiponectin transcript and HMW adiponectin levels in obese patients are self-explanatory.…”

Section: Discussionmentioning

confidence: 71%

A genetic analysis identifies a haplotype at adiponectin locus: Association with obesity and type 2 diabetes

Palit

Patel

Jadeja

et al. 2020

Sci Rep

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Adiponectin is a prime determinant of the status of insulin resistance. Association studies between adiponectin (ADIPOQ) gene single nucleotide polymorphisms (Snps) and metabolic diseases have been reported earlier. However, results are ambiguous due to apparent contradictions. Hence, we investigated (1) the association between ADIPOQ Snps: −11377C/G, +10211T/G, +45T/G and +276G/T for the risk towards type 2 diabetes (T2D) and, (2) genotype-phenotype association of these SNPs with various biochemical parameters in two cohorts. Genomic DNA of diabetic patients and controls from Gujarat and, Jammu and Kashmir (J&K) were genotyped using PCR-RFLP, TaqMan assay and MassArray. transcript levels of ADIPOQ were assessed in visceral adipose tissue samples, and plasma adiponectin levels were estimated by qPCR and ELISA respectively. Results suggest: (i) reduced HMW adiponectin/ total adiponectin ratio in Gujarat patients and its association with +10211T/G and +276G/T, and reduced ADIPOQ transcript levels in T2D, (ii) association of the above SNPs with increased FBG, BMI, TG, TC in Gujarat patients and (iii) increased GGTG haplotype in obese patients of Gujarat population and, (iv) association of −11377C/G with T2D in J&K population. Reduced HMW adiponectin, in the backdrop of obesity and ADIPOQ genetic variants might alter metabolic profile posing risk towards T2D.Metabolic Syndrome (MS) is the new wave of diseases that has hit the human population in the last few decadesthe Metabolic Syndrome Era. It has become pandemic and with obesity and type 2 diabetes (T2D) clubbed under the MS umbrella, millions of people around the globe have come under its grip. Though obesity and T2D are ubiquitous, there exists a pattern of prevalence based on ethnicity. A recent report has identified demographic transitions, nutrition and lifestyle in the backdrop of genetic predisposition as the chief factors responsible for the rising trend of obesity associated amongst South Asians 1 . Over accumulation of visceral adipose tissue (AT) has been identified as one of the major driving factors towards T2D. Adipose tissue is an important regulator of metabolic homeostasis by virtue of the adipokines (pro-inflammatory and anti-inflammatory) that it secretes. In obese conditions, the fine-tuned balance between the pro-and anti-inflammatory adipokines gets altered leading to various metabolic disorders 2 . These bioactive peptides act locally and distally to calibrate and fine tune various metabolic pathways. Adiponectin is one such calibrator which is abundantly expressed in white adipose tissue 3 . It circulates in three polymorphic forms, low molecular weight (LMW), moderate molecular weight (MMW) and high molecular weight (HMW). Interestingly, the ratio of plasma HMW adiponectin to total adiponectin is more strongly correlated with plasma glucose levels than any of the forms alone 4 . Adiponectin gene (ADIPOQ/ APM1/GBP28) locus, 3q27, has been strongly associated with a variety of metabolic disorders like-impaired glucose tolerance, obesity, dys...

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“…This research demonstrated that TLR4 serves as a receptor mediating the proinflammatory effects of resistin in human cells [153]. RETN 2KB upstream variant rs1862513 C has been found to correlate with a higher BMI [132,133]. This finding is in contrast to a study indicating that Retn KO mice do not manifest any alteration in adiposity [201].…”

Section: Other Cytokinesmentioning

confidence: 97%

Innate-Immunity Genes in Obesity

Михайлова

Ivanoshchuk

2021

JPM

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The main functions of adipose tissue are thought to be storage and mobilization of the body’s energy reserves, active and passive thermoregulation, participation in the spatial organization of internal organs, protection of the body from lipotoxicity, and ectopic lipid deposition. After the discovery of adipokines, the endocrine function was added to the above list, and after the identification of crosstalk between adipocytes and immune cells, an immune function was suggested. Nonetheless, it turned out that the mechanisms underlying mutual regulatory relations of adipocytes, preadipocytes, immune cells, and their microenvironment are complex and redundant at many levels. One possible way to elucidate the picture of adipose-tissue regulation is to determine genetic variants correlating with obesity. In this review, we examine various aspects of adipose-tissue involvement in innate immune responses as well as variants of immune-response genes associated with obesity.

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Genetic variants of resistin and its plasma levels: Association with obesity and dyslipidemia related to type 2 diabetes susceptibility

Cited by 22 publications

References 40 publications

Impacts of RETN genetic polymorphism on breast cancer development

Impacts of RETN genetic polymorphism on breast cancer development

A genetic analysis identifies a haplotype at adiponectin locus: Association with obesity and type 2 diabetes

Innate-Immunity Genes in Obesity

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