A genetic analysis identifies a haplotype at adiponectin locus: Association with obesity and type 2 diabetes

Palit, Sayantani Pramanik; Patel, Roma; Jadeja, Shahnawaz D.; Rathwa, Nirali; Mahajan, Ankit; Ramachandran, A. V.; Dhar, Manoj K.; Sharma, Swarkar; Begum, Rasheedunnisa

doi:10.1038/s41598-020-59845-z

Cited by 21 publications

(14 citation statements)

References 52 publications

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“…49 Singlenucleotide polymorphisms (SNPs) in the promoter region of the adiponectin gene may be associated with the development of insulin resistance, obesity, and T2DM. 50,51 Researchers have found H 2 S-reduced insulin sensitivity in adipocytes, and CSE inhibitors might reverse this effect. A high level of glucose (20 mmol/L) inhibited the H 2 S production of adipocytes in a time-and concentrationdependent manner.…”

Section: Hydrogen Sulfide and Insulin Resistance Of Adipose Tissuementioning

confidence: 99%

<p>Hydrogen Sulfide, Adipose Tissue and Diabetes Mellitus</p>

Zhu¹,

Yang²,

Ma³

et al. 2020

DMSO

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Hydrogen sulfide (H 2 S) is now increasingly considered to be the third gasotransmitter alongside other gaseous signaling molecules, nitric oxide (NO) and carbon monoxide (CO). H 2 S is produced by a variety of endogenous enzymatic and non-enzymatic pathways and acts as a modulator of the physiological and pathological events of the body. Adipocytes express the cystathionine γ lyase (CSE)/H 2 S system, which modulates a variety of biological activities in adipose tissue (AT), including inflammation, apoptosis, insulin resistance, adipokine secretion and adipocyte differentiation. Abnormalities in the physiological functions of AT play an important role in the process of diabetes mellitus. Therefore, this review provides an overview of the general aspects of H 2 S biochemistry, the effect of H 2 S on AT function and diabetes mellitus and its molecular signalling mechanisms as well as the potential application of H 2 S in pharmacotherapy.

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Section: Hydrogen Sulfide and Insulin Resistance Of Adipose Tissuementioning

confidence: 99%

<p>Hydrogen Sulfide, Adipose Tissue and Diabetes Mellitus</p>

Zhu¹,

Yang²,

Ma³

et al. 2020

DMSO

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“…The most significant, although without reaching p < 0.05, was rs1501299, which had already been previously analyzed in our initial list of the four pre-selected candidate SNPs in the ADIPOQ gene, therefore being consistent with our previous findings. The association between the candidate SNPs +276G > T (rs1501299) and +45T > G (rs2241766) with plasma adiponectin has been heterogeneous across diverse populations [ 29 , 41 , 46 , 47 , 48 , 49 , 50 , 95 , 96 ]. Of the four candidate SNPs analyzed, we only observed strong and additive associations for the −11391 G/A (rs17300539) polymorphism, in agreement with several studies showing significant associations for this variant [ 49 , 50 ].…”

Section: Discussionmentioning

confidence: 99%

Circulating Adiponectin and Its Association with Metabolic Traits and Type 2 Diabetes: Gene-Diet Interactions Focusing on Selected Gene Variants and at the Genome-Wide Level in High-Cardiovascular Risk Mediterranean Subjects

et al. 2021

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Adiponectin is gaining renewed interest since, in addition to its possible protective role against insulin resistance and arteriosclerosis, recent studies suggest other additional favorable effects. However, the influence of gene-diet interactions on plasma adiponectin levels is still little understood. We analyzed the association between plasma adiponectin levels and various metabolic traits in a high-cardiovascular risk Mediterranean population, as well as the genetic effect of four candidate single-nucleotide polymorphisms (SNPs) in the adiponectin gene (ADIPOQ) and their interactions with the Mediterranean dietary pattern. Additionally, we explored, at the genome-wide level, the SNPs most associated with plasma adiponectin levels, as well as gene–diet interactions with the Mediterranean diet. In the 954 participants studied (aged 55–80 years), plasma adiponectin levels were strongly associated with plasma HDL-C concentrations (p = 6.6 × 10−36) and inversely related to triglycerides (p = 4.7 × 10−18), fasting glucose (p = 3.5 × 10−16) and type 2 diabetes (p = 1.4 × 10−7). Of the four pre-selected ADIPOQ candidate SNPs, the one most associated with plasma adiponectin was the −11391G > A (rs17300539) promoter SNP (p = 7.2 × 10−5, in the multivariable adjusted model). No significant interactions with the Mediterranean diet pattern were observed for these SNPs. Additionally, in the exploratory genome-wide association study (GWAS), we found new SNPs associated with adiponectin concentrations at the suggestive genome-wide level (p < 1 × 10−5) for the whole population, including the lead SNP rs9738548 (intergenic) and rs11647294 in the VAT1L (Vesicle Amine Transport 1 Like) gene. We also found other promising SNPs on exploring different strata such as men, women, diabetics and non-diabetics (p = 3.5 × 10−8 for rs2850066). Similarly, we explored gene–Mediterranean diet interactions at the GWAS level and identified several SNPs with gene–diet interactions at p < 1 × 10−5. A remarkable gene–diet interaction was revealed for the rs2917570 SNP in the OPCML (Opioid Binding Protein/Cell Adhesion Molecule Like) gene, previously reported to be associated with adiponectin levels in some populations. Our results suggest that, in this high-cardiovascular risk Mediterranean population, and even though adiponectin is favorably associated with metabolic traits and lower type 2 diabetes, the gene variants more associated with adiponectin may be population-specific, and some suggestive gene–Mediterranean diet interactions were detected.

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“…Адипонектин является основной детерминантой развития резистентности к инсулину. Снижение уровня адипонектина на фоне ожирения и генетических полиморфизмов гена адипонектина (ADIPOQ) влечет за собой изменение метаболического профиля, создавая риск развития СД 2 [32]. В работе А.Ф.…”

Section: адипонектинunclassified

The pathophysiological role of adipokines in the development of bronchial asthma combined with obesity

Kytikovа

Юрьевна²,

Аntonyuk

et al. 2021

Terapevticheskii arkhiv

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The combined course of bronchial asthma (BA) and obesity is one of the urgent medical and social problems that requires a comprehensive and careful study in connection with a decrease in the quality of life of such patients, an increase in the frequency, duration of hospitalization and a high economic burden for the state as a whole. The relationship between BA and obesity is now confirmed by numerous studies, at the same time, despite the variability of the proposed mechanisms of pathogenetic effects of obesity on asthma, metabolic aspects of the relationship of these diseases need further study. Adipose tissue hormones are responsible for the energy homeostasis of the body therefore, excessive accumulation of adipose tissue is accompanied by the development of an imbalance in metabolic processes in various organs and tissues. Due to the emergence of new scientific data on the role and function of adipokines in the body, metabolic effects of adipokines are considered in the focus of their pathophysiological association with obesity and asthma. This literary review highlights the current understanding of the role of metabolic effects of the most studied adipokines (resistin, retinol-binding protein, leptin and adiponectin) in the development of obesity and BA. Gender and age-dependent features of adipokine levels in BA and obesity are described. Data on the confirmed role of adiponectin and leptin in the progression of BA combined with obesity are presented. It has been shown that the role of resistin and retinol-binding protein in the development of BA combined with obesity has not been studied. It is demonstrated that further study of metabolic activity of adipokines in BA is an actual and perspective direction of researches which will allow to develop new diagnostic and therapeutic strategies in patients with BA with obesity.

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A genetic analysis identifies a haplotype at adiponectin locus: Association with obesity and type 2 diabetes

Cited by 21 publications

References 52 publications

<p>Hydrogen Sulfide, Adipose Tissue and Diabetes Mellitus</p>

<p>Hydrogen Sulfide, Adipose Tissue and Diabetes Mellitus</p>

Circulating Adiponectin and Its Association with Metabolic Traits and Type 2 Diabetes: Gene-Diet Interactions Focusing on Selected Gene Variants and at the Genome-Wide Level in High-Cardiovascular Risk Mediterranean Subjects

The pathophysiological role of adipokines in the development of bronchial asthma combined with obesity

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