Genetic variability of inflammation and oxidative stress genes does not play a major role in the occurrence of adverse events of dopaminergic treatment in Parkinson’s disease

Redenšek, Sara; Flisar, Dušan; Kojović, Maja; Kramberger, Milica G.; Georgiev, Dejan; Pirtošek, Zvezdan; Trošt, Maja; Dolžan, Vita

doi:10.1186/s12974-019-1439-y

Cited by 24 publications

(32 citation statements)

References 77 publications

(93 reference statements)

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“…While previous studies have analyzed associations between the IL-10-1082 G/A (rs1800896) polymorphism with PD [2,12,13,17,34], none have been established with IL-10 -819 T/C (rs1800871) and IL-10 -592 C/A (rs1800872) polymorphisms [4,12,34,35]. In this metaanalysis, three additional studies [33,36,37] were included for the analysis of IL-10 -1082 G/A polymorphisms. Our analyses showed that the A allele (A vs. G, OR = 1.731; 95% CI 1.338-2.239, P = 0.000, I 2 = 0%, Fig.…”

Section: Resultsmentioning

confidence: 99%

Inflammation-related gene polymorphisms associated with Parkinson’s disease: an updated meta-analysis

Ulhaq

Garcia

2020

Egypt J Med Hum Genet

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Background: Strong evidence supports the involvement of inflammation processes in the development and progression of Parkinson's disease (PD), where increasingly correlations have been identified between genetic variations in inflammation-related genes and PD. However, data varies between studies. Therefore, we conducted a meta-analysis to clarify associations between inflammation-related gene polymorphisms and PD risk. Methods: All studies were identified through online databases. Pooled and stratified groups based on racial descent were assembled to evaluate associations between polymorphisms and PD. Results: The pooled results showed that protective effects for PD were observed for (1)

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Section: Resultsmentioning

confidence: 99%

Inflammation-related gene polymorphisms associated with Parkinson’s disease: an updated meta-analysis

Ulhaq

Garcia

2020

Egypt J Med Hum Genet

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“…In addition, the effects of the polymorphism on drug actions were not absolutely consistent. For example, patients with SOD2 rs4880 T allele taking dopaminergic anti-parkinson drugs had less nausea and vomiting, but the motor adverse reactions remained unchanged (32). Further, clozapine response in patients with schizophrenia had not been affected with Val16Ala SOD2 polymorphism (33).…”

Section: Discussionmentioning

confidence: 97%

Superoxide Dismutase 2 Val16Ala Polymorphism is Associated with Amiodarone-Associated Liver Injury

Radmanović

Jovanović

Djordjević

et al. 2022

Serbian Journal of Experimental and Clinical Research

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Association of SOD2 V16A single-nucleotide polymorphism (rs4880) with drug hepatotoxicity were reported but relationships with amiodarone prescriptions remained unexplored. Research was an exploratory, controlled prospective clinical trial. Patients hospitalized and treated in Clinical Center in Kragujevac, Serbia (in year 2017) were divided into experimental (using amiodarone, having liver injury, n=29, 19 males, the mean age 66.8±10.4 years), control A (neither amiodarone use nor hepatotoxicity, n=29, 19, 66.1±10.3) and control B group (using amiodarone, not having hepatotoxicity, n=29, 19, 66.8±9.8). From blood samples, among other routine biochemistry, genotyping for SOD2 polymorphism Val16Ala was conducted using real-time PCR method with TaqMan® Genotyping Master Mix and TaqMan® DME Genotyping Assay for rs4880. Patients taking amiodarone and having liver injury were mostly carriers of Val/Val (TT) genotype (13 of 24 patients, 54.2%) while Val/Ala (TC) and Ala/Ala (CC) genotypes prevailed in control group A (19 of 40, 47.5%) and control group B (9 of 23, 39.1%), respectively (2=10.409, p=0.034). Frequency of Val (T) and Ala (C) alleles were 0.51 and 0.49, respectively in the whole study sample (Hardy Weinberg equilibrium, 2=0.56, p=0.454). Carriers of TT genotype had significantly higher ALT (437.0±1158.0 vs 81.9131.5 U/L), total bilirubin (28.320.5 vs 15.313.0 mol/L) and total bile acid concentrations (10.910.2 vs 6.45.3 mol/L) compared to carriers of TC genotype (U=2.331, p=0.020, U=3.204, p=0.001 and U=2.172, p=0.030, respectively). Higher incidence of 47T allele of SOD2 was inpatients with amiodarone-associated liver injury as compared to patients on amiodarone not experiencing hepatotoxic effects.

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“…38 Buckman et al found that brain atrophy measured after head computerized tomography scans in patients with chronic SCZ was negatively correlated with GSH-px activity in platelets, which was more significant in patients with SCZ with negative symptoms as the core clinical manifestation. 39 Currently, a tremendous amount of domestic and foreign scientific research have proven that GPx-1 polymorphisms are associated with different diseases, such as coronary artery disease, 22 cancer, [40][41][42][43][44][45] diabetes and its vascular complications, 46 rheumatoid arthritis, 47 Huntington's disease, 48 PD, 26,49 autism, 50 and postpartum hemorrhage. 51 However, research into the involvement of GPx-1 in SCZ is lacking.…”

Section: Introductionmentioning

confidence: 99%

<p>Association Between Glutathione Peroxidase-1 (GPx-1) Polymorphisms and Schizophrenia in the Chinese Han Population</p>

Shao¹,

Yan²,

Sun³

et al. 2020

NDT

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The dopamine and oxidative stress hypotheses are leading theories of the pathoetiology of schizophrenia (SCZ). Glutathione Peroxidase 1 (GPx-1), a major antioxidant enzyme, and the most abundantly expressed member of the GPx family, plays an important role in metabolic dopamine changes, which are closely related to neurological and psychiatric disorders. The impact of GPx-1 polymorphisms has rarely been explored in the field of SCZ. Here, we explored the possible relationship between GPx-1 gene polymorphisms and SCZ in Chinese Han subjects by using the polymerase chain reaction-restriction fragment length polymorphism method. Methods: DNA from 786 patients (360 patients with schizophrenia and 426 healthy controls) was genotyped for the single-nucleotide polymorphisms rs1800668 C/T and rs1050450 C/T in GPx-1 using polymerase chain reaction-restriction fragment length polymorphism analysis. Analysis of the association between GPx-1 and SCZ was performed using SPSS 22.0, while Haploview 4.2 software and SHEsis software were used to perform linkage disequilibrium analysis and haplotype analysis. Results: The results indicated that the GPx-1 polymorphisms rs1050450 and rs1800668 were associated with SCZ. We found that the C-allele of rs1800668 C/T may be a protection factor against SCZ in general, but in particular, for males. Furthermore, the CT and TC (GPx-1 rs1800668 C/T and rs1050450 C/T) haplotypes may be susceptible to SCZ in the population. Finally, no significant differences in allelic or genotypic frequencies of rs1050450 were detected between cases and controls from whole or stratification analyses by gender. Conclusion: GPx-1 polymorphisms are related to SCZ in Chinese Han subjects. Our results suggested that GPx-1 may be a potential gene that influences SCZ.

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Genetic variability of inflammation and oxidative stress genes does not play a major role in the occurrence of adverse events of dopaminergic treatment in Parkinson’s disease

Cited by 24 publications

References 77 publications

Inflammation-related gene polymorphisms associated with Parkinson’s disease: an updated meta-analysis

Inflammation-related gene polymorphisms associated with Parkinson’s disease: an updated meta-analysis

Superoxide Dismutase 2 Val16Ala Polymorphism is Associated with Amiodarone-Associated Liver Injury

<p>Association Between Glutathione Peroxidase-1 (GPx-1) Polymorphisms and Schizophrenia in the Chinese Han Population</p>

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