Inflammation-related gene polymorphisms associated with Parkinson’s disease: an updated meta-analysis

Abstract

Background: Strong evidence supports the involvement of inflammation processes in the development and progression of Parkinson's disease (PD), where increasingly correlations have been identified between genetic variations in inflammation-related genes and PD. However, data varies between studies. Therefore, we conducted a meta-analysis to clarify associations between inflammation-related gene polymorphisms and PD risk. Methods: All studies were identified through online databases. Pooled and stratified groups based on racial descent were assembled to evaluate associations between polymorphisms and PD. Results: The pooled results showed that protective effects for PD were observed for (1)

The role of IL-6-174 G/C polymorphism and intraocular IL-6 levels in the pathogenesis of ocular diseases: a systematic review and meta-analysis

“…The I 2 values indicated no (0-24.9%), low (25-49.9%), moderate (50-74.9%) or high (75-100%) heterogeneity. The random-effect model (REM) was used if heterogeneity existed; otherwise, the fixed-effect model (FEM) was used 250,[276][277][278][279][280][281][282][283][284][285][286][287] . Subgroup analysis was stratified by type of disease and ethnicity or racial descent.…”

Anti-IL-6 receptor antibody treatment for severe COVID-19 and the potential implication of IL-6 gene polymorphisms in novel coronavirus pneumonia

“…The Newcastle–Ottawa scale (NOS) was used to assess the study quality, in which a score ≥ 7 is considered a good study. 5 , 6 , 7 , 8 , 9 , 10 …”

Anti-IL-6 receptor antibody treatment for severe COVID-19 and the potential implication of IL-6 gene polymorphisms in novel coronavirus pneumonia

“…The Newcastle–Ottawa scale (NOS) was used to assess the study quality, in which a score ≥ 7 is considered a good study. 5 , 6 , 7 , 8 , 9 , 10 …”