<p>Association Between Glutathione Peroxidase-1 (GPx-1) Polymorphisms and Schizophrenia in the Chinese Han Population</p>

Abstract

The dopamine and oxidative stress hypotheses are leading theories of the pathoetiology of schizophrenia (SCZ). Glutathione Peroxidase 1 (GPx-1), a major antioxidant enzyme, and the most abundantly expressed member of the GPx family, plays an important role in metabolic dopamine changes, which are closely related to neurological and psychiatric disorders. The impact of GPx-1 polymorphisms has rarely been explored in the field of SCZ. Here, we explored the possible relationship between GPx-1 gene polymorphisms and SCZ in Chinese Han subjects by using the polymerase chain reaction-restriction fragment length polymorphism method. Methods: DNA from 786 patients (360 patients with schizophrenia and 426 healthy controls) was genotyped for the single-nucleotide polymorphisms rs1800668 C/T and rs1050450 C/T in GPx-1 using polymerase chain reaction-restriction fragment length polymorphism analysis. Analysis of the association between GPx-1 and SCZ was performed using SPSS 22.0, while Haploview 4.2 software and SHEsis software were used to perform linkage disequilibrium analysis and haplotype analysis. Results: The results indicated that the GPx-1 polymorphisms rs1050450 and rs1800668 were associated with SCZ. We found that the C-allele of rs1800668 C/T may be a protection factor against SCZ in general, but in particular, for males. Furthermore, the CT and TC (GPx-1 rs1800668 C/T and rs1050450 C/T) haplotypes may be susceptible to SCZ in the population. Finally, no significant differences in allelic or genotypic frequencies of rs1050450 were detected between cases and controls from whole or stratification analyses by gender. Conclusion: GPx-1 polymorphisms are related to SCZ in Chinese Han subjects. Our results suggested that GPx-1 may be a potential gene that influences SCZ.

The ALA5/ALA6/ALA7 repeat polymorphisms of the glutathione peroxidase‐1 (GPx1) gene and autism spectrum disorder

“…Overall, there is considerable evidence that GPx1 polymorphisms have a strong association with some diseases (Buraczynska et al, 2017 ; Hong et al, 2013 ; Jerotic et al, 2019 ; Souiden et al, 2016 ; Wei et al, 2020 ). In particular, the polymorphic site containing the alanine stretch has been found to be related with cancer (Jefferies et al, 2005 ; Kote‐Jarai et al, 2002 ), cardiovascular diseases (Hamanishi et al, 2004 ), and mental disorders such as schizophrenia (Shao et al, 2020 ).…”

Sex-Specific Association between Antioxidant Defense System and Therapeutic Response to Risperidone in Schizophrenia: A Prospective Longitudinal Study

“…Specifically, GPx is the key enzyme for ADS in the brain tissue to scavenge excess H 2 O 2 because the CAT activity in the brain is low and is limited to peroxisomes. It has been confirmed that there is a close relationship between decreased GPx activity and the severity of schizophrenia, which may be related to DA metabolism [ 74 , 75 ]. Buckman et al found that brain atrophy was negatively correlated with GPx activity in patients with chronic schizophrenia [ 76 ].…”

Identification of Key Genes and Biological Pathways in Bipolar Disorder by Bioinformatics and Next Generation Sequencing Data Analysis

“…Immune system [51], axon guidance [52], metabolism [53], diseases of metabolism [54] and neuronal system [55] were lined with advancement of BD. Altered expression of SLC6A9 [56] and RHD (Rh blood group D antigen) [57], CHRFAM7A [58], ANXA3 [59], SLC1A5 [60], KCNH2 [61], HP (haptoglobin) [62], SELENBP1 [63], SNCA (synuclein alpha) [64], TGM2 [65], PINK1 [66], B2M [67], QPCT (glutaminyl-peptide cyclotransferase) [68], CBS (cystathionine beta-synthase) [69], NQO2 [70], GLRX5 [71], BASP1 [72], GAS7 [73], GPX1 [74], OLIG2 [75], RPTN (repetin) [76], IL33 [77], SOX10 [78], GRIK1 [79], ZFPM2 [80], SHANK3 [81], ERBB3 [82], ARC (activity regulated cytoskeleton associated protein) [83], GFAP (glial fibrillary acidic protein) [84], PLAT (plasminogen activator, tissue type) [85], GRIK5 [86], CACNB2 [87], NRXN2 [88], TERT (telomerase reverse transcriptase) [89], GNB3 [90], L1CAM [91], EGR3 [92], CAV1 [93], CACNA1B [94], MAGI1 [95], KIR2DL1 [96], PAH (phenylalanine hydroxylase) [97] and CYP3A5 [98] have been shown in schizophrenia. Recent studies showed that SLC6A9 [99], FKBP1B [100], S100A12 [101], SLC6A19 [102], TXN (thioredoxin) [103], TLR9 [104], HP (haptoglobin) [105], ARG1 [106], PINK1 [107], B2M [108], C5AR1 [109], MYADM (myeloid associated differentiation marker) [110], CBS (cystathionine beta-synthase) [111], GPX1 [112], SIAH2 [113], PRDX2 [114], RDH8 [115], CYP11B2 [116], RARRES2 [117], NOX1 [118], IL33 [119], OTC (ornithine transcarbamylase) [120], CYP1A1 […”