Genetic susceptibility to severe asthma with fungal sensitization

Overton, Nicola; Simpson, Angela; Bowyer, Paul; Denning, David W.

doi:10.1111/iji.12312

Cited by 32 publications

(24 citation statements)

References 83 publications

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“…Dectin‐1 is involved in fungal‐mediated allergic inflammation mediating T‐helper 17 (Th17) cell differentiation . Genetic polymorphisms of Dectin‐1, TLR3, and TLR9 are significantly associated with susceptibility to severe asthma with fungal sensitization . Dectin‐2 has been implicated in allergic inflammation to house dust mites with Th2 polarization .…”

Section: C‐type Lectin Receptorsmentioning

confidence: 99%

Innate immunity in allergy

Maeda

Caldez

Akira

2019

Allergy

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Innate immune system quickly responds to invasion of microbes and foreign substances through the extracellular and intracellular sensing receptors, which recognize distinctive molecular and structural patterns. The recognition of innate immune receptors leads to the induction of inflammatory and adaptive immune responses by activating downstream signaling pathways. Allergy is an immune‐related disease and results from a hypersensitive immune response to harmless substances in the environment. However, less is known about the activation of innate immunity during exposure to allergens. New insights into the innate immune system by sensors and their signaling cascades provide us with more important clues and a framework for understanding allergy disorders. In this review, we will focus on recent advances in the innate immune sensing system.

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Section: C‐type Lectin Receptorsmentioning

confidence: 99%

Innate immunity in allergy

Maeda

Caldez

Akira

2019

Allergy

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“…Cross-presenting dendritic cells harboring this variant displayed an impaired expression of TLR3 and sensing of fungal RNA, which ultimately resulted in the defective priming of memory CD8(+) T-cell responses to A. fumigatus. This study was recently supported by evidence demonstrating a similar association with severe asthma with fungal sensitization (Overton et al 2017). Although there is no evidence implicating this regulatory variant in susceptibility to infections by Candida, the non-synonymous SNP rs3775291 (L412F) in TLR3 was however detected more frequently in patients suffering from chronic mucocutaneous candidiasis (CMC) (Nahum et al 2011).…”

Section: Toll-like Receptorsmentioning

confidence: 75%

Host Genetic Signatures of Susceptibility to Fungal Disease

Campos

Veerdonk

Gonçalves

et al. 2018

Fungal Physiology and Immunopathogenesis

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Our relative inability to predict the development of fungal disease and its clinical outcome raises fundamental questions about its actual pathogenesis. Several clinical risk factors are described to predispose to fungal disease, particularly in immunocompromised and severely ill patients. However, these alone do not entirely explain why, under comparable clinical conditions, only some patients develop infection. Recent clinical and epidemiological studies have reported an expanding number of monogenic defects and common polymorphisms associated with fungal disease. By directly implicating genetic variation in the functional regulation of immune mediators and interacting pathways, these studies have provided critical insights into the human immunobiology of fungal disease. Most of the common genetic defects reported were described or suggested to impair fungal recognition by the innate immune system. Here, we review common genetic variation in pattern recognition receptors and its impact on the immune response against the two major fungal pathogens Candida albicans and Aspergillus fumigatus. In addition, we discuss potential strategies and opportunities for the clinical translation of genetic information in the field of medical mycology. These approaches are expected to transfigure current clinical practice by unleashing an unprecedented ability to personalize prophylaxis, therapy and monitoring for fungal disease.

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“…The sensitisation to Asp f 1, Asp f 3 and Asp f 6 was altogether confimed on 22 patients (36%). Aspergillus fumigatus as a ubiquitous fungus can be found in the respiratory tract of the asthmatic and healthy people (Overton, Simpson, Bowyer, & Denning, 2017;Woolnough et al, 2017). The inhalation of Aspergillus spores leads to an immune response in individuals.…”

Section: Discussionmentioning

confidence: 99%

Sensitisation to molecular allergens of Alternaria alternata, Cladosporium herbarum, Aspergillus fumigatus in atopic dermatitis patients

Čelakovská

Bukač

Vaňková

et al. 2019

Food and Agricultural Immunology

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The aim of this study is the evaluation of the sensitisation to molecular allergens of Alternaria alternata, Aspergillus fumigatus and Cladosporium herbarum in atopic dermatitis patients. The complete dermatological and allergological examination including the examination of the sensitisation to molecular allergens with Multiplex ISAC testing was performed in all included patients. The statistical evaluation of the relation between the sensitisation to Alt a 1, Alt a 6, Cla h 8, Asp f 1, Asp f 3, Asp f 6 and other molecular food and inhalant allergens was performed. The sensitisation to molecular fungal allergen was recorded altogether in 58% patients; it is in significant relation to the sensitisation to some food and inhallant molecular allergens, such as Peanut,

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Genetic susceptibility to severe asthma with fungal sensitization

Cited by 32 publications

References 83 publications

Innate immunity in allergy

Innate immunity in allergy

Host Genetic Signatures of Susceptibility to Fungal Disease

Sensitisation to molecular allergens of Alternaria alternata, Cladosporium herbarum, Aspergillus fumigatus in atopic dermatitis patients

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