Sensitisation to molecular allergens of Alternaria alternata, Cladosporium herbarum, Aspergillus fumigatus in atopic dermatitis patients

Čelakovská, Jarmila; Bukač, Josef; Vaňková, R.; Krčmová, Irena; Krejsek, Jan; Andrýs, Ctirad

doi:10.1080/09540105.2019.1660624

Cited by 6 publications

(2 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alternaria is a genus known for the production of both host-specific and unspecific mycotoxins [25], but neither A. betae-kenyensis nor A. subcucurbitae have so far undergone genome sequencing or a thorough metabolomic analysis, so it is difficult to speculate about their role or effect in Phoenix dactylifera microbiomes. Cladosporium herbarum is mostly known as epiphyte on leaves, but also for its production of allergens [26][27][28][29]. However, dates are never consumed at this stage of development, so its presence does not pose a health risk.…”

Section: Discussionmentioning

confidence: 99%

Characterizing the Fungal Microbiome in Date (Phoenix dactylifera) Fruit Pulp and Peel from Early Development to Harvest

et al. 2020

View full text Add to dashboard Cite

Date palm (Phoenix dactylifera) is considered to be a highly important food crop in several African and Middle Eastern countries due to its nutritional value and health-promoting properties. Microbial contamination of dates has been of concern to consumers, but very few works have analyzed in detail the microbial load of the different parts of date fruit. In the present work, we characterized the fungal communities of date fruit using a metagenomic approach, analyzing the data for differences between microbial populations residing in the pulp and peel of “Medjool” dates at the different stages of fruit development. The results revealed that Penicillium, Cladosporium, Aspergillus, and Alternaria were the most abundant genera in both parts of the fruit, however, the distribution of taxa among the time points and tissue types (peel vs. pulp) was very diverse. Penicillium was more abundant in the pulp at the green developmental stage (Kimri), while Aspergillus was more frequent in the peel at the brown developmental stage (Tamer). The highest abundance of Alternaria was detected at the earliest sampled stage of fruit development (Hababauk stage). Cladosporium had a high level of abundance in peel tissues at the Hababauk and yellow (Khalal) stages. Regarding the yeast community, the abundance of Candida remained stable up until the Khalal stage, but exhibited a dramatic increase in abundance at the Tamer stage in peel tissues, while the level of Metschnikowia, a genus containing several species with postharvest biocontrol activity, exhibited no significant differences between the two tissue types or stages of fruit development. This work constitutes a comprehensive metagenomic analysis of the fungal microbiome of date fruits, and has identified changes in the composition of the fungal microbiome in peel and pulp tissues at the different stages of fruit development. Notably, this study has also characterized the endophytic fungal microbiome present in pulp tissues of dates.

show abstract

Section: Discussionmentioning

confidence: 99%

Characterizing the Fungal Microbiome in Date (Phoenix dactylifera) Fruit Pulp and Peel from Early Development to Harvest

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Few works have been published addressing the diagnosis of fungal allergy using the CRD with the most common fungal allergens available [ 3 , 8 , 23 , 42 , 62 , 63 , 64 ]. All of the existing studies agree that A. alternata sensitization is the most prevalent in allergic patients to fungi and that Alt a 1 is an accurate marker to test species-specific sensitization or IgE-mediated allergy to A. alternata.…”

Section: Molecular Diagnosis and Fungal Moleculesmentioning

confidence: 99%

Fungal Allergen and Mold Allergy Diagnosis: Role and Relevance of Alternaria alternata Alt a 1 Protein Family

Sánchez

Vélez-del-Burgo

Suñén

et al. 2022

JoF

View full text Add to dashboard Cite

Alternaria is a genus of worldwide fungi found in different habitats such as soil, the atmosphere, plants or indoor environments. Alternaria species are saprobic—largely involved in the decomposition of organic material—but they can also act as animal pathogens, causing disease in humans and animals, developing infections, toxicosis and allergic diseases. A. alternata is considered one of the most important sources of fungal allergens worldwide and it is associated with severe asthma and respiratory status. Among the A. alternata allergens, Alt a 1 is the main sensitizing allergen and its usefulness in diagnosis and immunotherapy has been demonstrated. Alt a 1 seems to define a protein family that can be used to identify related pathogenic fungi in plants and fruits, and to establish taxonomic relationships between the different fungal divisions.

show abstract

Occurrence of Cladosporium colombiae as a first record in Iraq

Abdulla¹,

Abbas²

2022

The 9th International Conference on Applied Science and Technology (Icast 2021)

View full text Add to dashboard Cite

Sensitisation to molecular allergens of Alternaria alternata, Cladosporium herbarum, Aspergillus fumigatus in atopic dermatitis patients

Cited by 6 publications

References 42 publications

Characterizing the Fungal Microbiome in Date (Phoenix dactylifera) Fruit Pulp and Peel from Early Development to Harvest

Characterizing the Fungal Microbiome in Date (Phoenix dactylifera) Fruit Pulp and Peel from Early Development to Harvest

Fungal Allergen and Mold Allergy Diagnosis: Role and Relevance of Alternaria alternata Alt a 1 Protein Family

Occurrence of Cladosporium colombiae as a first record in Iraq

Contact Info

Product

Resources

About