Genetic Risk for Ischemic and Hemorrhagic Stroke

Yamada, Yoshiji; Metoki, Norifumi; Yoshida, Hidemi; Satoh, Kei; Ichihara, Sahoko; Kato, Koichi; Kameyama, Tetsuya; Yokoi, Kiyoshi; Matsuo, Hitoshi; Segawa, Tomio; Watanabe, Soichi; Nozawa, Yoshinori

doi:10.1161/01.atv.0000229694.97827.38

Cited by 94 publications

(83 citation statements)

References 33 publications

(28 reference statements)

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“…We found that the IL-6 rs1800796 TT genotype was greatly associated with risk of ischemic stroke, and that the IL-6 rs1800795 CC genotype was marginally associated with risk of ischemic stroke. Our finding is consistent with previous studies conducted in Chinese, Japanese, American, and British populations (Humphries et al, 2001;Yamada et al, 2006;Podgoreanu et al, 2006;Tong et al, 2010). This finding suggests that in individuals carrying the TT genotype of IL-6 rs1800796, IL-6 transcription can be influenced through a complex interaction, and a previous study indicated that the T allele of rs1800796 was associated with increased transcription efficiency of IL-6 (Terry et al, 2000).…”

Section: Discussionsupporting

confidence: 92%

Role of inflammatory parameters in the susceptibility of cerebral thrombosis

Feng

Yang

et al. 2014

Genet. Mol. Res.

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ABSTRACT. We aimed to investigate the association of inflammationrelated genes such as IL-10, IL-6 and IL-1B with risk of ischemic stroke. We included 426 cases with ischemic stroke and 426 health controls from Xinxiang, China. Genomic DNA was extracted from the buffy coat layer of collected blood with the TIANamp blood DNA kit. Diabetes, hypertension, obesity, and smoking habits were associated with risk of ischemic stroke. We found that individuals carrying the CC genotype of IL-1B rs1864169 had a higher risk of ischemic stroke when compared with the TT genotype (OR = 1.80, 95%CI = 1.16-2.80). The IL-6 rs1800796 TT genotype was associated with increased risk of ischemic stroke. We found that IL-1B rs1864169 and IL-6 rs1800796 polymorphisms may interact with diabetes, hypertension and obesity. Our study suggests that IL-6 rs1800796 and IL-1B rs1864169 Inflammatory parameters and cerebral thrombosis polymorphisms are associated with ischemic stroke risk in the Chinese population.

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Section: Discussionsupporting

confidence: 92%

Role of inflammatory parameters in the susceptibility of cerebral thrombosis

Feng

Yang

et al. 2014

Genet. Mol. Res.

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“…With the use of public databases, including PubMed (NCBI) and Online Mendelian Inheritance in Man (NCBI), we selected 202 candidate genes that have been characterized and suggested to be associated with atherothrombotic cerebral infarction. On the basis of published studies or by searching PubMed and single nucleotide polymorphism (SNP) databases [dbSNP (NCBI) and Japanese SNP database (JSNP)], we further selected 296 polymorphisms of these genes, most located in the promoter region or exons, that might be expected to result in changes in the function or expression of the encoded protein (14,15). Wild-type and variant alleles of the polymorphisms were determined from the original sources.…”

Section: Methodsmentioning

confidence: 99%

Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome

Yamada

Kato²,

Oguri³

et al. 2008

Int J Mol Med

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Abstract. Metabolic syndrome is a risk factor for cardiovascular disease. The aim of the present study was to identify genetic variants that confer susceptibility to atherothrombotic cerebral infarction among individuals with metabolic syndrome in order to allow prediction of genetic risk for this condition. The study population comprised 1284 unrelated Japanese individuals with metabolic syndrome, including 313 subjects with atherothrombotic cerebral infarction and 971 controls. The genotypes for 296 polymorphisms of 202 candidate genes were determined with a method that combines the polymerase chain reaction and sequence-specific oligonucleotide probes with suspension array technology. The Chisquare test, multivariable logistic regression analysis with adjustment for age, sex, body mass index, and the prevalence of hypertension, hypercholesterolemia, and diabetes mellitus, as well as a stepwise forward selection procedure revealed that the 2445G¨A (Ala54Thr) polymorphism (rs1799883) of FABP2, the -108/3G¨4G polymorphism of IPF1 (S82168), the A¨G (Thr94Ala) polymorphism (rs2241883) of FABP1, the G¨A (Asp2213Asn) polymorphism (rs529038) of ROS1, the -11377C¨G polymorphism (rs266729) of ADIPOQ, the 162A¨C polymorphism (rs4769055) of ALOX5AP, the -786T¨C polymorphism (rs2070744) of NOS3, and the 3279C¨T polymorphism (rs7291467) of LGALS2 were associated (P<0.05) with the prevalence of atherothrombotic cerebral infarction. Among these polymorphisms, the 2445G¨A (Ala54Thr) polymorphism of FABP2 was most significantly associated with this condition. Our results suggest that FABP2, IPF1, FABP1, ROS1, ADIPOQ, ALOX5AP, NOS3, and LGALS2 are susceptibility loci for atherothrombotic cerebral infarction among Japanese individuals with metabolic syndrome. Genotypes for these polymorphisms, especially for the 2445G¨A (Ala54Thr) polymorphism of FABP2, may prove informative for the prediction of genetic risk for atherothrombotic cerebral infarction among such individuals.

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“…The 150 polymorphisms examined in the present study (data not shown) were selected by genome-wide association studies of ischemic stroke and myocardial infarction (P-value for allele frequency <1.0x10 -7 ) with the use of the GeneChip Human Mapping 500K Array Set (Affymetrix, Santa Clara, CA) (10). We have not examined the relation of these polymorphisms to intracerebral or subarachnoid hemorrhage among Japanese individuals in our previous study (8,9).…”

Section: Selection Of Polymorphismsmentioning

confidence: 95%

“…We previously showed that several gene polymorphisms were associated with intracerebral or subarachnoid hemorrhage in Japanese individuals (7,8). To further examine the genetic factors for these conditions, we have performed an association study for 150 polymorphisms of 144 candidate genes and intracerebral or subarachnoid hemorrhage in 4,304 Japanese individuals.…”

Section: Introductionmentioning

confidence: 99%

Association of genetic variants with hemorrhagic stroke in Japanese individuals

Yoshida

Kato²,

Yokoi³

et al. 2010

Int J Mol Med

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Abstract.Although genetic epidemiological studies have implicated several genetic variants as risk factors for hemorrhagic stroke, the genetic determinants of this condition remain largely unknown. We examined an association of genetic variants with intracerebral or subarachnoid hemorrhage among Japanese individuals. The study population comprised 4,304 unrelated Japanese individuals, including 377 subjects with intracerebral hemorrhage, 205 subjects with subarachnoid hemorrhage, and 3,722 controls. The 150 polymorphisms examined in the present study were selected by genome-wide association studies of ischemic stroke and myocardial infarction with the use of the GeneChip Human Mapping 500K Array Set. The chi-square test, multivariable logistic regression analysis with adjustment for covariates, as well as a stepwise forward selection procedure revealed that the C→T polymorphism (rs1324694) of ERLIN1, the C→T polymorphism (rs12679196) of TRAPPC9, and the G→T polymorphism (rs16936752) of WNK2 were significantly (P<0.05) associated with the prevalence of intracerebral hemorrhage, and that the A→G polymorphism (rs3111754) of ITM2C and the A→G polymorphism (rs10986769) of MAPKAP1 were significantly associated with the prevalence of subarachnoid hemorrhage. Genotypes for ERLIN1, TRAPPC9, and WNK2 may prove informative for assessment of the genetic risk for intracerebral hemorrhage, and those for ITM2C and MAPKAP1 may be beneficial in assessment of the genetic risk for subarachnoid hemorrhage in Japanese individuals.

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Genetic Risk for Ischemic and Hemorrhagic Stroke

Cited by 94 publications

References 33 publications

Role of inflammatory parameters in the susceptibility of cerebral thrombosis

Role of inflammatory parameters in the susceptibility of cerebral thrombosis

Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome

Association of genetic variants with hemorrhagic stroke in Japanese individuals

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