Role of inflammatory parameters in the susceptibility of cerebral thrombosis

Qi, Xiyou; Feng, T.; Yang, Ping; Feng, Hongyan; Zhang, P; Kong, Lingfeng; Liang, Dan; Li, P F; Na, W; Li, Y W; Wang, Y

doi:10.4238/2014.april.16.1

Cited by 8 publications

(8 citation statements)

References 19 publications

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“…These 3 polymorphisms were found to occur in frequencies consistent with HWE in the control populations of the vast majority of the published studies. There were 10 studies based on Asian population, 4 , 13 , 16 , 17 , 20 , 23 , 25 , 28 , 32 , 48 16 studies conducted in white population, 10 , 14 , 18 , 19 , 21 , 22 , 26 , 27 , 29 – 31 , 44 – 47 and 2 studies from mixed population. 15 , 24 Among these included studies, cases were generally recruited in referral centers with documented CAD or stroke, and the controls were without any direct evidence of overt disease.…”

Section: Resultsmentioning

confidence: 99%

Association Between 3 IL-10 Gene Polymorphisms and Cardiovascular Disease Risk

Yang¹,

Wang

Huang³

et al. 2016

Medicine

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Section: Resultsmentioning

confidence: 99%

Association Between 3 IL-10 Gene Polymorphisms and Cardiovascular Disease Risk

Yang¹,

Wang

Huang³

et al. 2016

Medicine

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“…The genotype of IL-6 is also involved in this process. The IL-6 genotype was significantly associated with thrombosis in children [52] and increased risk of ischemic stroke [53]. …”

Section: Discussionmentioning

confidence: 99%

Promoter Polymorphism (-174, G/C) of Interleukin-6 and Arterial Thromboembolic Events: A Meta-Analysis

2016

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BackgroundIschemic stroke and myocardial infarction are fatal diseases and are among the top 10 causes of death in Korea, including arterial thromboembolic events. Many previous studies have described the function of interleukin-6 (IL-6) in arterial thromboembolic events and the association between promoter single-nucleotide polymorphism (SNP) (rs1800795; −174, G/C) of the IL-6 gene. However, these results were controversial. Therefore, we performed a meta-analysis to more precisely assess the association between the SNP of the IL-6 gene and susceptibility to arterial thromboembolic events.Material/MethodsWe used PubMed, Embase, Google Scholar, and Korean Studies Information Service System (KISS) electronic databases. Comprehensive Meta-analysis software (Corporation, NJ) was used to evaluate the relationship between rs1800795 SNP of IL-6 gene and risk of arterial thromboembolic events. Odds ratio (OR), 95% confidence interval (CI), and P value were also calculated. The 13 eligible studies were analyzed in the meta-analysis.ResultsThe present meta-analysis found that rs1800795 SNP of IL-6 gene is not significantly associated with susceptibility to arterial thromboembolic events (C allele vs. G allele, OR=1.04, 95% CI=0.91–1.19, P=0.619; CC vs. CG+GG, OR=1.09, 95% CI=0.91–1.31, P=0.364; CC+CG vs. GG, OR=0.97, 95% CI=0.78–1.21, P=0.763, respectively), and the SNP of IL-6 gene also did not show any significant association with ischemic stroke or myocardial infarction (P>0.05 in each model).ConclusionsWe found that rs1800795 SNP of IL-6 gene was not related to arterial thromboembolic events. However, further study will be needed to confirm these results.

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“…GQ Sun et al [ 28 ] found that the IL-6 rs1800795 G>C polymorphisms presented an increased risk in dominant and recessive models, but they did not find that the IL-6 rs1800796 CC were correlated with an increased risk of coronary artery disease. A study reported that the rs1800796 TT genotype was associated with increased the susceptibility of cerebral thrombosis in the Chinese population [ 29 ]. Previous meta-analysis demonstrated significant association between rs1800796 of IL6 and cancer risk, with the allele G as a risk allele [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Determination of IL-1B (rs16944) and IL-6 (rs1800796) genetic polymorphisms in IgA nephropathy in a northwest Chinese Han population

et al. 2017

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IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide, but etiology and pathogenesis continue to be poorly understood. Polymorphisms in the cytokine genes may play a role in the etiology and pathogenesis of IgAN. The incidence of different between diverse ethnic groups suggested important genetic influences on its pathogenesis.We genotype 10 single nucleotide polymorphisms (SNPs) in IL-1B and IL-6 gene using Sequenom Mass-ARRAY technology from 417 IgAN patients and 463 healthy controls of the Chinese Han population. We evaluated these SNPs associated with IgAN utilising the chi-square tests and genetic model analysis.We identified that the minor alleles of rs16944 (“A”), rs1800796 (“G”) in IL-1B, IL-6 were involved in an increasingly risk of IgAN in allelic model analysis, respectively. The rs16944 in IL-1B and rs1800796 in IL-6 were associated with 1.23-fold (95% CI, 1.02-1.48, P = 0.031) and 1.33-fold (95% CI, 1.11-1.66, P = 0.003) increases in the risk of developing IgAN, respectively. There was only rs1800796 still correlated with IgAN in the allelic model after adjustment by age and gender and the Bonferroni correction. In addition, Haplotype Grs1800796A rs2069837G rs2069840 (P = 0.037) and G rs1800796A rs2069837C rs2069840 (P = 0.042) in IL-6were considered to be associated with increased IgAN risk.This study verified the IL-6, IL-1B genetic variants polymorphisms contributed to IgAN susceptibility in a Chinese Han population. Although we identified SNPs susceptibility, however, replication studies and functional research are required to confirm the genetic contribution in IgAN.

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Role of inflammatory parameters in the susceptibility of cerebral thrombosis

Cited by 8 publications

References 19 publications

Association Between 3 IL-10 Gene Polymorphisms and Cardiovascular Disease Risk

Association Between 3 IL-10 Gene Polymorphisms and Cardiovascular Disease Risk

Promoter Polymorphism (-174, G/C) of Interleukin-6 and Arterial Thromboembolic Events: A Meta-Analysis

Determination of IL-1B (rs16944) and IL-6 (rs1800796) genetic polymorphisms in IgA nephropathy in a northwest Chinese Han population

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